methyl 2-(4-((pyridin-2-yl)methoxy)phenyl)acetate | 158606-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl 2-(4-((pyridin-2-yl)methoxy)phenyl)acetate
• 英文别名: 4-(pyridin-2-ylmethoxy)phenylacetic acid methyl ester；4-(2-pyridylmethoxy)phenylacetic acid methyl ester；methyl 2-[4-(pyridin-2-ylmethoxy)phenyl]acetate
• CAS: 158606-71-4
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.289
• InChiKey: NJFGJBZWNZYYIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-(4-((pyridin-2-yl)methoxy)phenyl)acetate 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3-(2-(4-((3-Benzoyl-1-cyanoindolizin-5-yl)methoxy)phenyl)-4-methylpentanamido)-3-phenylpropanoic acid
  参考文献：
  名称：

  3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

  摘要：

  In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.051
• 作为产物：
  描述：

  2-吡啶甲醇 、 4-羟基苯乙酸甲酯 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以75%的产率得到methyl 2-(4-((pyridin-2-yl)methoxy)phenyl)acetate
  参考文献：
  名称：

  3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

  摘要：

  In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.051

文献信息

• Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis
  申请人：Abbott Laboratories

  公开号：US05358955A1

  公开（公告）日：1994-10-25

  The present invention relates to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein W is selected from optionally substituted pyridyl, naphthyl, and quinolyl; which inhibits lipoxygenase enzyme activity and leukotriene biosynthesis and is useful in the treatment of inflammatory disease states; also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting lipoxygenase enzyme activity and leukotriene biosynthesis.

  本发明涉及以下式的化合物##STR1##或其药学上可接受的盐，其中W选自可选择的取代吡啶基、萘基和喹啉基；该化合物抑制脂氧合酶酶活性和白三烯生物合成，在治疗炎症性疾病状态中有用；还公开了抑制白三烯生物合成的组合物和抑制脂氧合酶酶活性和白三烯生物合成的方法。
• US5358955A
  申请人：——

  公开号：US5358955A

  公开（公告）日：1994-10-25
• US7495020B2
  申请人：——

  公开号：US7495020B2

  公开（公告）日：2009-02-24
• 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors
  作者：Timo Weide、Lars Arve、Heino Prinz、Herbert Waldmann、Horst Kessler

  DOI：10.1016/j.bmcl.2005.09.051

  日期：2006.1

  In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines. (c) 2005 Elsevier Ltd. All rights reserved.