tert-butyl (3,3-diethoxypropyl)(4-methoxybenzyl)carbamate | 1396518-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tert-butyl (3,3-diethoxypropyl)(4-methoxybenzyl)carbamate
• 英文别名: tert-butyl N-(3,3-diethoxypropyl)-N-[(4-methoxyphenyl)methyl]carbamate
• CAS: 1396518-25-4
• 化学式: C₂₀H₃₃NO₅
• 分子量: 367.486
• InChiKey: LHLYBAIWWMVONW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl (3,3-diethoxypropyl){(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate 在 chloro (2-dicyclohexylphosphino-2 ‘,4’,6’-triisopropyl-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 、 potassium carbonate 、 caesium carbonate 作用下， 以 水 、 丙酮 、 甲苯 为溶剂， 反应 4.67h， 生成 tert-butyl (3,3-diethoxypropyl)(4-methoxybenzyl)carbamate
  参考文献：
  名称：

  Potassium Boc-Protected Secondary Aminomethyltrifluoroborates: Synthesis and Suzuki–Miyaura Cross-Coupling Reactions

  摘要：

  Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.

  DOI：

  10.1021/ol301955s

文献信息

• Potassium Boc-Protected Secondary Aminomethyltrifluoroborates: Synthesis and Suzuki–Miyaura Cross-Coupling Reactions
  作者：Gary A. Molander、Inji Shin

  DOI：10.1021/ol301955s

  日期：2012.9.7

  Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.