2-acetylaminomethyl-5-phenyltetrazole | 659741-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-acetylaminomethyl-5-phenyltetrazole
• 英文别名: N-[(5-phenyltetrazol-2-yl)methyl]acetamide
• CAS: 659741-18-1
• 化学式: C₁₀H₁₁N₅O
• 分子量: 217.23
• InChiKey: LRJLVAJFUBQGGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-acetylaminomethyl-5-phenyltetrazole 在 盐酸 作用下， 反应 1.0h， 以95%的产率得到5-苯基四氮唑
  参考文献：
  名称：

  摘要：

  Amidoalkylation of 5-aryl(hetaryl)tetrazoles with N-hydroxymethylamides of aliphatic and aromatic carboxylic acids occurs regioselectively and yields mainly 5-aryl(hetaryl)-2-acylaminomethyltetrazoles. These compounds are fairly stable in neutral media but are smoothly deprotected by the action of aqueous sodium hydroxide or hydrochloric acid.

  DOI：

  10.1023/a:1026034001881
• 作为产物：
  描述：

  乙酰胺 、 聚合甲醛 、 5-苯基四氮唑 在 sodium hydroxide 作用下， 反应 0.66h， 以79%的产率得到2-acetylaminomethyl-5-phenyltetrazole
  参考文献：
  名称：

  摘要：

  Amidoalkylation of 5-aryl(hetaryl)tetrazoles with N-hydroxymethylamides of aliphatic and aromatic carboxylic acids occurs regioselectively and yields mainly 5-aryl(hetaryl)-2-acylaminomethyltetrazoles. These compounds are fairly stable in neutral media but are smoothly deprotected by the action of aqueous sodium hydroxide or hydrochloric acid.

  DOI：

  10.1023/a:1026034001881

文献信息

• ——
  作者：L. V. Myznikov、K. A. Esikov、T. V. Artamonova、G. I. Koldobskii

  DOI：10.1023/a:1026034001881

  日期：——

  Amidoalkylation of 5-aryl(hetaryl)tetrazoles with N-hydroxymethylamides of aliphatic and aromatic carboxylic acids occurs regioselectively and yields mainly 5-aryl(hetaryl)-2-acylaminomethyltetrazoles. These compounds are fairly stable in neutral media but are smoothly deprotected by the action of aqueous sodium hydroxide or hydrochloric acid.