(E)-N-methacryloylbut-2-enamide | 1449232-11-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-N-methacryloylbut-2-enamide
• 英文别名: (E)-N-(2-methylprop-2-enoyl)but-2-enamide
• CAS: 1449232-11-4
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: LOQCBOUDWPSCQW-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2E)-2-丁烯酰胺 、 甲基丙烯酰氯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.25h， 生成 (E)-N-methacryloylbut-2-enamide
  参考文献：
  名称：

  Compounds, Compositions, and Methods for Cancer Therapy

  摘要：

  本文披露了包括各种辣椒酸丁酯的寡聚体和/或辣椒酸丁酯类似物以及表现出对癌细胞有改进毒性的某些辣椒酸丁酯类似物的化合物。还提供了包括这些化合物的组合物、制备包括这些化合物的组合物的方法、制备这些化合物的方法，以及在治疗癌症方法中使用这些化合物的用途。

  公开号：

  US20140024639A1

文献信息

• Compounds, Compositions, and Methods for Cancer Therapy
  申请人：The Broad Institute, Inc.

  公开号：US20140024639A1

  公开（公告）日：2014-01-23

  Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed. Also provided are compositions that comprise the compounds, methods of making compositions comprising the compounds, methods of making the compounds, and the use of compounds in methods for treating cancer.

  本文披露了包括各种辣椒酸丁酯的寡聚体和/或辣椒酸丁酯类似物以及表现出对癌细胞有改进毒性的某些辣椒酸丁酯类似物的化合物。还提供了包括这些化合物的组合物、制备包括这些化合物的组合物的方法、制备这些化合物的方法，以及在治疗癌症方法中使用这些化合物的用途。
• Compounds, compositions, and methods for cancer therapy
  申请人：The Broad Institute, Inc.

  公开号：US09108923B2

  公开（公告）日：2015-08-18

  Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed. Also provided are compositions that comprise the compounds, methods of making compositions comprising the compounds, methods of making the compounds, and the use of compounds in methods for treating cancer.

  本发明公开了包括各种辣椒碱寡聚体和/或辣椒碱类似物的化合物，以及某些表现出对癌细胞毒性改善的辣椒碱类似物。此外，还提供了包括这些化合物的组合物、制备这些组合物的方法、制备这些化合物的方法以及在治疗癌症的方法中使用这些化合物的用途。
• US9108923B2
  申请人：——

  公开号：US9108923B2

  公开（公告）日：2015-08-18
• [EN] CROSSLINKING PROCESS<br/>[FR] PROCÉDÉ DE RÉTICULATION
  申请人：NORNER IP AS

  公开号：WO2014108517A2

  公开（公告）日：2014-07-17

  A process for crosslinking a poly(alkylene carbonate) (PAC) in the presence of a metal ion, said process comprising: a) adding a crosslinking agent to said poly(alkylene carbonate) and b) crosslinking the resulting product of step a); so as to form a crosslinked PAC in which the crosslinks formed involve the complexation of the metal ion to said PAC and said crosslinking agent.
• Synthesis of piperlogs and analysis of their effects on cells
  作者：Zarko V. Boskovic、Mahmud M. Hussain、Drew J. Adams、Mingji Dai、Stuart L. Schreiber

  DOI：10.1016/j.tet.2013.05.080

  日期：2013.9

  Piperlongumine (PL) is a naturally occurring small molecule previously shown to induce cell death preferentially in cancer cells relative to non-cancer cells. An initial effort to synthesize analogs highlighted the reactivities of both of piperlongumine's alpha,beta-unsaturated imide functionalities as key features determining PL's cellular effects. In this study, a second-generation of analogs was synthesized and evaluated in cells to gain further insight into how the reactivity, number, and orientation of PL's reactive olefins contribute to its ability to alter the physiology of cells. (C) 2013 Elsevier Ltd. All rights reserved.