2-(bis(trimethylsilyl)methylthio)acetic acid | 1430111-70-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(bis(trimethylsilyl)methylthio)acetic acid
• 英文别名: 2-[Bis(trimethylsilyl)methylsulfanyl]acetic acid；2-[bis(trimethylsilyl)methylsulfanyl]acetic acid
• CAS: 1430111-70-8
• 化学式: C₉H₂₂O₂SSi₂
• 分子量: 250.509
• InChiKey: SRVPPSVHKQFVOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.93
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(bis(trimethylsilyl)methylthio)acetic acid 在 双氧水 、 三氯氧磷 作用下， 以 溶剂黄146 为溶剂， 反应 24.0h， 生成 2-((bis(trimethylsilyl)methylsulfonyl)methyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Syntheses and anti-allergic activity of 2-((bis(trimethylsilyl)methylthio/methylsulfonyl)methyl)-5-aryl-1,3,4-oxadiazoles

  摘要：

  A new class of sila-substituted 1,3,4-oxadiazoles was synthesized by a convenient synthetic method. Both silathio/silasulfonyl acetic acids were efficiently condensed with benzohydrazides in the presence of phosphorus oxychloride to give sila-substituted 1,3,4-oxadiazoles in high yields. The compounds displayed variable extent of anti-allergic activity on IgE/Ag-stimulated RBL-2H3 cells at 50 and 100 mu M concentrations. Compounds having sulfonyl moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (5a-c), exhibited better anti-allergic activities than those of compounds having sulphur moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (4a-c). (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.12.035
• 作为产物：
  描述：

  二(三甲基硅基)氯甲烷 、 巯基乙酸 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以86%的产率得到2-(bis(trimethylsilyl)methylthio)acetic acid
  参考文献：
  名称：

  Syntheses and anti-allergic activity of 2-((bis(trimethylsilyl)methylthio/methylsulfonyl)methyl)-5-aryl-1,3,4-oxadiazoles

  摘要：

  A new class of sila-substituted 1,3,4-oxadiazoles was synthesized by a convenient synthetic method. Both silathio/silasulfonyl acetic acids were efficiently condensed with benzohydrazides in the presence of phosphorus oxychloride to give sila-substituted 1,3,4-oxadiazoles in high yields. The compounds displayed variable extent of anti-allergic activity on IgE/Ag-stimulated RBL-2H3 cells at 50 and 100 mu M concentrations. Compounds having sulfonyl moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (5a-c), exhibited better anti-allergic activities than those of compounds having sulphur moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (4a-c). (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.12.035

文献信息

• Syntheses and anti-allergic activity of 2-((bis(trimethylsilyl)methylthio/methylsulfonyl)methyl)-5-aryl-1,3,4-oxadiazoles
  作者：Dinneswara Reddy Guda、Sae-Jin Park、Min-Woo Lee、Tack-Joong Kim、Myong Euy Lee

  DOI：10.1016/j.ejmech.2012.12.035

  日期：2013.4

  A new class of sila-substituted 1,3,4-oxadiazoles was synthesized by a convenient synthetic method. Both silathio/silasulfonyl acetic acids were efficiently condensed with benzohydrazides in the presence of phosphorus oxychloride to give sila-substituted 1,3,4-oxadiazoles in high yields. The compounds displayed variable extent of anti-allergic activity on IgE/Ag-stimulated RBL-2H3 cells at 50 and 100 mu M concentrations. Compounds having sulfonyl moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (5a-c), exhibited better anti-allergic activities than those of compounds having sulphur moiety with bis(trimethylsilyl)-1,3,4-oxadiazoles (4a-c). (C) 2013 Elsevier Masson SAS. All rights reserved.