5,7-Difluoro-L-tryptophan | 53314-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5,7-Difluoro-L-tryptophan
• 英文别名: (2S)-2-amino-3-(5,7-difluoro-1H-indol-3-yl)propanoic acid
• CAS: 53314-96-8
• 化学式: C₁₁H₁₀F₂N₂O₂
• 分子量: 240.21
• InChiKey: CGUGQOKZDNVVIL-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods of unnatural amino acid incorporation in mammalian cells
  申请人：Neurion Pharmaceuticals

  公开号：US20040259256A1

  公开（公告）日：2004-12-23

  The present invention discloses a general method for the efficient delivery of suppressor tRNA and mRNA or DNA encoding a protein of interest to mammalian cells. The method of electroporation described herein is useful for expanding nonsense suppression methodology to mammalian cell expression systems for the incorporation of unnatural amino acids.
• [EN] METHODS OF UNNATURAL AMINO ACID INCORPORATION IN MAMMALIAN CELLS<br/>[FR] METHODES D'INCORPORATION D'ACIDES AMINES NON NATURELS DANS DES CELLULES MAMMIFERES
  申请人：NEURION PHARMACEUTICALS

  公开号：WO2004085463A2

  公开（公告）日：2004-10-07

  The present invention discloses a general method for the efficient delivery of suppressor tRNA and mRNA or DNA encoding a protein of interest to mammalian cells. The method of electroporation described herein is useful for expanding nonsense suppression methodology to mammalian cell expression systems for the incorporation of unnatural amino acids.