4,4'-bis-(2-thienyl)-2,2'-bithiazole | 18332-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,4'-bis-(2-thienyl)-2,2'-bithiazole
• 英文别名: 4,4'-bis(2-thienyl)-2,2'-bithiazole；4,4'-di-thiophen-2-yl-[2,2']bithiazolyl；4,4'-Di-α-thienyl)-2,2'-dithiazolyl；4-(Thiophen-2-YL)-2-[4-(thiophen-2-YL)-1,3-thiazol-2-YL]-1,3-thiazole；4-thiophen-2-yl-2-(4-thiophen-2-yl-1,3-thiazol-2-yl)-1,3-thiazole
• CAS: 18332-26-8
• 化学式: C₁₄H₈N₂S₄
• mdl: MFCD00713443
• 分子量: 332.495
• InChiKey: GRQIKFZTUVPQDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  139
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-tosyloxy-1-(2-thiophenyl)ethanone 以 乙醇 为溶剂， 反应 8.0h， 生成 4,4'-bis-(2-thienyl)-2,2'-bithiazole
  参考文献：
  名称：

  A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS

  摘要：

  Alpha-tosyloxyacetylthiophene (3), obtained by the hypervalent iodine oxidation of 2-acetylthiophene (2) using [hydroxy(tosyloxy)iodo]benzene (HTIB), on treatment with rubeanic acid exclusively generates 4-(2-thienyl)thiazole-2-thiocarboxamide (4) which upon subsequent treatment with a variety of alpha-tosyloxyketones (5) affords the title compounds (G) in excellent yields.

  DOI：

  10.1081/scc-100108224

文献信息

• Singh, S P; Ranjana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 11, p. 782 - 783
  作者：Singh, S P、Ranjana

  DOI：——

  日期：——
• A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-4′-(2-THIENYL)- 2,2′-BITHIAZOLES AS POTENTIAL PHOTOTOXIC AGENTS
  作者：Shiv P. Singh、Rajesh Naithani、Ranjana Aggarwal、Om Prakash

  DOI：10.1081/scc-100108224

  日期：2001.1.1

  Alpha-tosyloxyacetylthiophene (3), obtained by the hypervalent iodine oxidation of 2-acetylthiophene (2) using [hydroxy(tosyloxy)iodo]benzene (HTIB), on treatment with rubeanic acid exclusively generates 4-(2-thienyl)thiazole-2-thiocarboxamide (4) which upon subsequent treatment with a variety of alpha-tosyloxyketones (5) affords the title compounds (G) in excellent yields.