3-(4-ethoxy-phenyl)-5-furfurylidene-2-thioxo-thiazolidin-4-one | 101274-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-ethoxy-phenyl)-5-furfurylidene-2-thioxo-thiazolidin-4-one
• 英文别名: 3-(4-Aethoxy-phenyl)-5-furfuryliden-2-thioxo-thiazolidin-4-on；(Z)-3-(4-ethoxyphenyl)-5-(furan-2-ylmethylene)-2-thioxothiazolidin-4-one；(5Z)-3-(4-ethoxyphenyl)-5-(furan-2-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
• CAS: 101274-35-5
• 化学式: C₁₆H₁₃NO₃S₂
• 分子量: 331.416
• InChiKey: ZHLDMMOPBUECBW-UVTDQMKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  糠醛 、 alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 作用下， 生成 3-(4-ethoxy-phenyl)-5-furfurylidene-2-thioxo-thiazolidin-4-one
  参考文献：
  名称：

  Wagner, Monatshefte fur Chemie, 1906, vol. 27, p. 1241

  摘要：

  DOI：

文献信息

• [EN] RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES DE RHODANINE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2004043955A1

  公开（公告）日：2004-05-27

  This invention describes rhodanine derivatives and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating cell proliferative diseases such as cancers.

  这项发明描述了罗丹宁衍生物和制药组合物，可用作泛素化抑制剂。该发明的化合物和组合物可用作参与泛素化的生物体的生化途径的抑制剂。特别地，这些化合物和组合物可用于治疗细胞增殖性疾病，如癌症。
• Rhodanine derivatives and pharmaceutical compositions containing them
  申请人：Singh Rajinder

  公开号：US20060276520A1

  公开（公告）日：2006-12-07

  This invention describes rhodanine derivatives and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating cell proliferative diseases such as cancers.

  本发明描述了罗丹宁衍生物和药物组合物，用于抑制泛素化。本发明的化合物和组合物可用作生物体中泛素化涉及的生物化学通路的抑制剂。特别地，这些化合物和组合物可用于治疗细胞增殖性疾病，如癌症。
• RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS
  申请人：Singh Rajinder

  公开号：US20090137644A1

  公开（公告）日：2009-05-28

  This invention describes compounds and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating diseases caused by viruses such as poxviruses and retroviruses. The invention further provides for methods of treating smallpox, Herpes virus and HIV infection in patients using the compounds and compositions of the invention.

  这项发明描述了化合物和制药组合物，可用作泛素化抑制剂。该发明的化合物和组合物可用作生物体中泛素化参与的生化途径的抑制剂。特别是，该化合物和组合物可用于治疗由病毒引起的疾病，如痘病毒和逆转录病毒。该发明还提供了使用该化合物和组合物治疗天花、疱疹病毒和HIV感染患者的方法。
• Ganitkewitsch, Sbornik Nauchnykh Rabot, L'vovskii Gosudarstvennyi Meditsinskii Institut, 1957, vol. 12, p. 64,66
  作者：Ganitkewitsch

  DOI：——

  日期：——
• Ganitkewitsch; Turkewitsch, Zhurnal Obshchei Khimii, 1959, vol. 29, p. 2092,2093; engl. Ausg. S. 2061, 2062
  作者：Ganitkewitsch、Turkewitsch

  DOI：——

  日期：——