2-(苄氧基)苯基乙酸酯 | 1000787-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 2-(苄氧基)苯基乙酸酯
• 英文名称: (2-Phenylmethoxyphenyl) acetate
• CAS: 1000787-20-1
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: XEPQFHKUZKADOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(苄氧基)苯基乙酸酯 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 以100%的产率得到(2-羟基苯基)乙酸酯
  参考文献：
  名称：

  2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors

  摘要：

  A new series of non-peptidic, mono-acid protein tyrosine phosphatase 1B (PTP1B) inhibitors has been identified by structure-based design. Compounds with 2-(indol-3-yl)- and 2-phenyl-3,3,3-trifluoro-2-hydroxypropionic acid core units targeted at the enzyme's primary site and a hydrophobic chlorophenylthiazole extension in its 2 degrees site exhibit 3-60 mu M IC(50)s for PTP1B inhibition in an Sf9 cell-based assay. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.069
• 作为产物：
  描述：

  2-苯甲氧基苯酚 、 乙酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到2-(苄氧基)苯基乙酸酯
  参考文献：
  名称：

  2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors

  摘要：

  A new series of non-peptidic, mono-acid protein tyrosine phosphatase 1B (PTP1B) inhibitors has been identified by structure-based design. Compounds with 2-(indol-3-yl)- and 2-phenyl-3,3,3-trifluoro-2-hydroxypropionic acid core units targeted at the enzyme's primary site and a hydrophobic chlorophenylthiazole extension in its 2 degrees site exhibit 3-60 mu M IC(50)s for PTP1B inhibition in an Sf9 cell-based assay. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.069

文献信息

• Novel lactam metalloprotease inhibitors
  申请人：——

  公开号：US20020042398A1

  公开（公告）日：2002-04-11

  The present application describes novel lactams and derivatives thereof of formula I: 1 or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide comprising 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.

  本申请描述了具有以下结构的新型内酰胺及其衍生物：1或其药用盐形式，其中环B是一个由0-3个额外的杂原子N、O和S选择的4-8元环酰胺，这些化合物可用作金属蛋白酶抑制剂。
• PYRAZOLE INHIBITORS OF WNT SIGNALING
  申请人：Brunton Shirley Ann

  公开号：US20100137394A1

  公开（公告）日：2010-06-03

  The invention provides inhibitors of Wnt signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein R1 to R7 and Z are as defined herein.

  该发明提供了Wnt信号通路的抑制剂，其可用作治疗恶性肿瘤的治疗剂，其中化合物具有一般式I：其中R1至R7和Z的定义如本文所述。
• Compounds and compositions for delivering active agents
  申请人：Emisphere Technologies, Inc.

  公开号：EP2279732A2

  公开（公告）日：2011-02-02

  Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

  提供了用于递送活性剂的化合物和组合物。还提供了给药和制备方法。
• ENDOTHELIN ANTAGONISTS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0792265A1

  公开（公告）日：1997-09-03
• NOVEL LACTAM METALLOPROTEASE INHIBITORS
  申请人：Du Pont Pharmaceuticals Company

  公开号：EP1027332A1

  公开（公告）日：2000-08-16