2-benzoyl-N-p-tolylbenzamide | 7143-48-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzoyl-N-p-tolylbenzamide
• 英文别名: 2-Benzoylbenz-p-toluidid；2-Benzoyl-n-(4-methylphenyl)benzamide
• CAS: 7143-48-8
• 化学式: C₂₁H₁₇NO₂
• 分子量: 315.371
• InChiKey: AJJIJMOHVJJIBW-UHFFFAOYSA-N

物化性质

• 沸点：
  447.0±38.0 °C(Predicted)
• 密度：
  1.200±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲苯基异腈 、 2-碘代苯甲酮 在 2,6-二甲基吡啶 、 copper(I) oxide 作用下， 以 水 为溶剂， 反应 1.0h， 以82%的产率得到2-benzoyl-N-p-tolylbenzamide
  参考文献：
  名称：

  Nanodomain cubic copper (I) oxide as reusable catalyst for the synthesis of amides by amidation of aryl halides with isocyanides

  摘要：

  An environmentally benign chemical process for the C-C coupling of aryl halides with isocyanides in aqueous medium has been developed using cubic copper (I) oxide nanoparticles as reusable catalyst. The use of nano-catalyst eliminates the use of any stabilizing ligands or additives as well as the use of organic solvents. The catalyst exhibited comparable efficiency up to three recycles and was found to be very effective for the synthesis of varied amides leading to biologically significant scaffold. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.12.060

文献信息

• Nanodomain cubic copper (I) oxide as reusable catalyst for the synthesis of amides by amidation of aryl halides with isocyanides
  作者：Swarbhanu Sarkar、Rammyani Pal、Manas Roy、Nivedita Chatterjee、Sabyasachi Sarkar、Asish Kumar Sen

  DOI：10.1016/j.tetlet.2014.12.060

  日期：2015.1

  An environmentally benign chemical process for the C-C coupling of aryl halides with isocyanides in aqueous medium has been developed using cubic copper (I) oxide nanoparticles as reusable catalyst. The use of nano-catalyst eliminates the use of any stabilizing ligands or additives as well as the use of organic solvents. The catalyst exhibited comparable efficiency up to three recycles and was found to be very effective for the synthesis of varied amides leading to biologically significant scaffold. (C) 2014 Elsevier Ltd. All rights reserved.