2-isopropyl-acrylic acid amide | 857574-89-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-isopropyl-acrylic acid amide
• 英文别名: 2-Isopropyl-acrylsaeure-amid；isopropyl acrylamide；isopropylacrylamide；3-Methyl-2-methylen-butyramid；2-Methylen-3-methylbutanamid；3-Methyl-2-methylidenebutanamide
• CAS: 857574-89-1
• 化学式: C₆H₁₁NO
• mdl: MFCD19203609
• 分子量: 113.159
• InChiKey: QPMZMJZDPOJMLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-二甲氧基四氢呋喃 、 2-isopropyl-acrylic acid amide 在 溶剂黄146 作用下， 反应 5.0h， 以83%的产率得到3-methyl-2-methylene-1-(1H-pyrrol-1-yl)butan-1-one
  参考文献：
  名称：

  Morita, Masataka; Drouin, Ludovic; Motoki, Rie, Journal of the American Chemical Society, 2009, vol. 131, p. 3858 - 3859

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-2-亚甲基-丁酸 在 五氯化磷 作用下， 生成 2-isopropyl-acrylic acid amide
  参考文献：
  名称：

  Gol'mow; Afanas'ew, Zhurnal Obshchei Khimii, 1952, vol. 22, p. 1953,1956; engl. Ausg. S. 2001, 2004

  摘要：

  DOI：

文献信息

• PROGRAMMABLE THERMORESPONSIVE GELS
  申请人：City of Hope

  公开号：US20200121598A1

  公开（公告）日：2020-04-23

  Provided herein, inter alia, are non-crosslinked polymers that possess thermoresponsive properties. These polymers possess a cleavable bond that breaks under certain conditions The disclosure also provides pharmaceutical compositions containing the polymers and therapeutic agents, methods for delivering the therapeutic agents, and kits, syringes, and catheters containing the polymer compositions and therapeutic agents.

  本文提供了具有热响应性能的非交联聚合物。这些聚合物具有在特定条件下断裂的可切割键。该公开还提供了含有这些聚合物和治疗剂的药物组合物、传递治疗剂的方法，以及含有聚合物组合物和治疗剂的工具包、注射器和导管。
• [EN] NANOPARTICLES FOR DIAGNOSIS AND DRUG DELIVERY<br/>[FR] NANOPARTICULES POUR LE DIAGNOSTIC ET L'ADMINISTRATION DE MÉDICAMENT
  申请人：CONSEJO SUPERIOR DE INVESTIG CIENTÍFICAS (CSIC)

  公开号：WO2017050979A1

  公开（公告）日：2017-03-30

  The present invention relatesto a nanoparticle having a size comprised from 2 to 300 nm comprising: (i) a core comprising on its surface a noble metal selected from gold, silver or platinum, and (ii) an optionally positively charged amphiphilic linker comprising a hydrophobic C1-C20 alkyl thiolate moiety and a hydrophilic moietywhich is optionally hydrophilic positively charged. The invention also provides nanovectors comprising the nanoparticles of the invention and a compound of interest,such as a pharmaceutically active agent, in particular an anti-tumoral agent. Also provided are nanoparticles and nanovectors as defined above for diagnosis or for the prevention and/or treatment of a disease, in particular cancer.

  本发明涉及一种纳米粒子，其尺寸范围为2到300纳米，包括：(i) 一个核心，其表面包括选自金、银或铂的贵金属，以及(ii
• [EN] BIORESPONSIVE POLYMER SYSTEM FOR DELIVERY OF MICROBICIDES<br/>[FR] SYSTEME POLYMERE BIOSENSIBLE POUR L'ADMINISTRATION DE MICROBICIDES
  申请人：UNIV UTAH RES FOUND

  公开号：WO2005097210A1

  公开（公告）日：2005-10-20

  The polymer systems of the present invention degrade in the presence of an ejaculate. They may further provide degradable sequences that degrade upon contact with an ejaculate and/or microbicides. The polymer systems of the present invention are of use in the oral, rectal or vaginal cavities of an individual for such purposes as the treatment or prevention of sexually transmitted disease, the prevention or promotion of fertility or for hormone replacement therapy.

  本发明的聚合物系统在射精的存在下降解。它们还可以提供在接触射精和/或杀微生物剂时降解的可降解序列。本发明的聚合物系统适用于个人的口腔、直肠或阴道腔道，用于治疗或预防性传播疾病、预防或促进生育或用于激素替代疗法。
• [EN] CELLULAR SIGNALLING INHIBITORS, THEIR FORMULATIONS AND METHODS THEREOF<br/>[FR] INHIBITEURS DE SIGNALISATION CELLULAIRE, LEURS FORMULES ET LEURS PROCÉDÉS
  申请人：INVICTUS ONCOLOGY PVT LTD

  公开号：WO2017137958A1

  公开（公告）日：2017-08-17

  The present disclosure relates generally to Cellular Signalling inhibitors of compound of Formula (I), compositions and formulations comprising the same, methods, processes, and uses thereof. In particular, the present disclosure provides CSF-1R inhibitors demonstrating sustained inhibition of CSF/CSF1R signalling pathway with decreased toxicity. The present disclosure also provides supramolecular combinatorial therapeutics, wherein a CSF-1R inhibitor is combined with one or more of a chemotherapeutic agent, a kinase inhibitor, and an immunoregulator, each of which is optionally conjugated with a lipid. The present disclosure also provides a method for treating cancer, allergy, Systemic lupus erythematosus, nephritis, Chronic Obstructive Pulmonary Disease, and abnormal macrophage functions or any combinations thereof.

  本公开涉及一般细胞信号传导抑制剂，涉及式(I)的化合物、包含该化合物的组合物和制剂、以及它们的方法、过程和使用。特别是，本公开提供了CSF-1R抑制剂，它们表现出对CSF/CSF1R信号通路的持续抑制，并且毒性降低。本公开还提供了超分子组合疗法，其中CSF-1R抑制剂与一个或多个化疗剂、激酶抑制剂和免疫调节剂结合，其中每个可选地与脂质偶联。本公开还提供了一种治疗癌症、过敏、系统性红斑狼疮、肾炎、慢性阻塞性肺病和异常巨噬细胞功能或其任何组合的方法。
• [EN] LIGHT HARVESTING ARRAY<br/>[FR] RÉSEAU COLLECTEUR DE LUMIÈRE
  申请人：FLUROSOL IND PTY LTD

  公开号：WO2015024064A1

  公开（公告）日：2015-02-26

  The invention relates to a light harvesting array or dye comprising an acceptor linked to a donor, wherein at least one of the acceptor or the donor is an oligomeric unit comprising a first optionally substituted rylene linked via a linker group to a second optionally substituted rylene, the first optionally substituted rylene is linked to the acceptor or the donor and the second optionally substituted rylene is capable of energy transfer to at least one of the first optionally substituted rylene, the acceptor or the donor. The invention also relates to compounds which may be used as light harvesting arrays, methods for their manufacture, and devices and materials comprising the light harvesting array or dye, for example, chromophoric materials, light guides, photobioreactors, photoluminescent algae systems, photodetectors, photovoltaic devices and luminescent/fluorescent solar concentrators.

  该发明涉及一种光收集阵列或染料，包括一个与给体相连的受体，其中受体或给体中至少有一个是包含第一可选择取代的芳香烃单元通过连接基团连接到第二可选择取代的芳香烃的寡聚单元，第一可选择取代的芳香烃与受体或给体相连，第二可选择取代的芳香烃能够将能量传递至第一可选择取代的芳香烃、受体或给体中的至少一个。该发明还涉及可用作光收集阵列的化合物，其制造方法，以及包括光收集阵列或染料的设备和材料，例如，色素材料、光导管、光生物反应器、光致发光藻类系统、光探测器、光伏器件和发光/荧光太阳能聚光器。