2-[((2,3,4,9-四氢-6-苯基-1H-咔唑-1-基)氨基]乙醇 | 6044-86-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2-[((2,3,4,9-四氢-6-苯基-1H-咔唑-1-基)氨基]乙醇
• 中文别名: 2-[(2,3,4,9-四氢-6-苯基-1H-咔唑-1-基)氨基]乙醇；2-((6-苯基-2,3,4,9-四氢-1H-咔唑-1-基)氨基)乙醇；干酪素
• 英文名称: casin
• 英文别名: 2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol
• CAS: 6044-86-6；425399-05-9
• 化学式: C₂₀H₂₂N₂O
• 分子量: 306.407
• InChiKey: RXIUMAOXORBRCY-UHFFFAOYSA-N

物化性质

• 沸点：
  584.7±33.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  48
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Compositions and Methods for Viral Inhibition
  申请人：Ni Zhi-Jie

  公开号：US20070276009A1

  公开（公告）日：2007-11-29

  The present invention discloses methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including carbazole derivatives useful for viral inhibition.

  本发明揭示了病毒抑制的方法和组合物，特别是对HCV和SARS的抑制。本发明还提供了包括咔唑衍生物的组合物，用于病毒抑制。
• Platelet storage methods and compositions for same
  申请人：Children's Hospital Medical Center

  公开号：US10028503B2

  公开（公告）日：2018-07-24

  Disclosed are compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.

  所公开的是用于减缓、预防或逆转血小板损伤的组合物和方法，尤其是在血库或冷藏血小板过程中可能发生的损伤。组合物可包括一种或多种 RAC 抑制剂、CDC42 抑制剂、RHOA 抑制剂或其组合。组合物可进一步包括药学上可接受的载体。
• Methods and use of compounds that bind to RelA of NF-kB
  申请人：Cedars-Sinai Medical Center

  公开号：US10881641B2

  公开（公告）日：2021-01-05

  The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA activity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.

  本发明提供了调节 RelA 活性的方法和制剂。 这些方法和 RelA 活性调节剂可用于治疗基底样乳腺癌（如三阴性乳腺癌）的癌症进展。
• MOBILIZATION OF HEMATOPOIETIC STEM CELLS
  申请人：Zheng Yi

  公开号：US20110020274A1

  公开（公告）日：2011-01-27

  Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
• REJUVENATION OF PRECURSOR CELLS
  申请人：Children's Hospital Medical Center

  公开号：US20150297563A1

  公开（公告）日：2015-10-22

  The present invention relates generally to methods and pharmaceutical compositions for rejuvenating hematopoietic stem cells and progenitor cells from blood, intestinal tissue and dermal tissue by administration of at least one inhibitor of a GT-Pase, such as Cdc42 GTPase.