N-(4-hydroxy-2,6-dimethylheptan-2-yl)acetamide | 1356999-92-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-hydroxy-2,6-dimethylheptan-2-yl)acetamide
• CAS: 1356999-92-2
• 化学式: C₁₁H₂₃NO₂
• 分子量: 201.309
• InChiKey: DEOHARKSRYEYMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二异丁基甲醇 、 乙腈 在 zinc trifluoromethanesulfonate 、 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(hexafluorophosphate) 、 copper(ll) bromide 、 sodium hydroxide 作用下， 以 乙腈 、 水 为溶剂， 以84%的产率得到N-(4-hydroxy-2,6-dimethylheptan-2-yl)acetamide
  参考文献：
  名称：

  Intermolecular Ritter-Type C–H Amination of Unactivated sp³Carbons

  摘要：

  Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.

  DOI：

  10.1021/ja212020b

文献信息

• Intermolecular Ritter-Type C–H Amination of Unactivated sp³Carbons
  作者：Quentin Michaudel、Damien Thevenet、Phil S. Baran

  DOI：10.1021/ja212020b

  日期：2012.2.8

  Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.