1-<4-Acetamino-phenyl>-thiophen | 91568-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-<4-Acetamino-phenyl>-thiophen
• 英文别名: N-(4-(thiophen-2-yl)phenyl)acetamide；4-(2-thienyl)-acetoanilide；4-(thiophen-2-yl)acetanilide；N-[4-(2-Thienyl)phenyl]acetamide；N-(4-thiophen-2-ylphenyl)acetamide
• CAS: 91568-98-8
• 化学式: C₁₂H₁₁NOS
• mdl: MFCD04039156
• 分子量: 217.291
• InChiKey: APWDLDHMDGYFLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-<4-Acetamino-phenyl>-thiophen 在 copper(ll) sulfate pentahydrate 、 硫酸 potassium carbonate 、 potassium hydroxide 作用下， 以 乙二醇 、 1,2-二氯乙烷 为溶剂， 反应 28.5h， 生成 Methyl 3-[4-(4-thiophen-2-ylanilino)phenyl]propanoate
  参考文献：
  名称：

  Thiazolothiazole compound and thiazolothiazole polymer

  摘要：

  该发明提供了以下式（I）所表示的噻唑噻唑化合物。在式（I）中，Ar1代表取代或未取代的芳香基团；R1代表氢原子、烷基、取代或未取代的芳基团，或取代或未取代的芳基烷基团；n代表0或1的整数。该发明还提供了一种以该噻唑噻唑化合物作为聚合单元的噻唑噻唑聚合物。

  公开号：

  US08207348B2
• 作为产物：
  描述：

  2-噻吩硼酸 、 N-(4-碘苯基)乙酰胺 在 resin-plug bound Pd sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以74%的产率得到1-<4-Acetamino-phenyl>-thiophen
  参考文献：
  名称：

  Reusable resin plug-bound palladium catalysts for organic synthesis

  摘要：

  Resin plugs, a unique and conveniently handled form of resin, prepared by sintering high-density polyethylene (HDPE) with pre-functionalised resins, were derivatised and loaded with palladium(0). These 'plugs' were used in the preparation of a Suzuki reaction based library and the removal of allyl ester protecting groups. The 'plugs of catalyst' were easily separated from the reaction mixture and were re-used multiple times with minimal loss of activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00977-8

文献信息

• Novel Carbazole Compound, and Polymer Thereof
  申请人：HIROSE Hidekazu

  公开号：US20080312453A1

  公开（公告）日：2008-12-18

  The present invention provides a carbazole compound represented by the following formula (I): wherein each Ar 1 independently represents a substituted or unsubstituted monovalent aromatic group or an aromatic group containing a heteroring, and R 1 and each R 2 independently represent a hydrogen atom, an alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group.

  本发明提供了一种由下式(I)表示的咔唑化合物：其中，每个Ar1独立地表示一个取代的或未取代的单价芳香族基团或含杂环的芳香族基团，R1和每个R2独立地表示一个氢原子、一个烷基、一个取代的或未取代的芳基或一个取代的或未取代的芳烷基。
• A base-free, one-pot diazotization/cross-coupling of anilines with arylboronic acids
  作者：Fanyang Mo、Di Qiu、Yubo Jiang、Yan Zhang、Jianbo Wang

  DOI：10.1016/j.tetlet.2010.11.099

  日期：2011.1

  Pd-catalyzed one-pot diazotization/cross-coupling is realized for the synthesis of biaryls directly from anilines and arylboronic acids.

  实现了钯催化的一锅重氮化/交叉偶联，可直接从苯胺和芳基硼酸合成联芳基。
• Chemical compounds
  申请人：——

  公开号：US20040082583A1

  公开（公告）日：2004-04-29

  Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文描述了作为TIE-2和/或VEGFR2抑制剂有用的苯并咪唑衍生物。所述发明还包括制备这种苯并咪唑衍生物的方法，以及在治疗过度增殖性疾病中使用它们的方法。
• Thiophene-containing compound and thiophene-containing compound polymer
  申请人：Ohba Yoshihiro

  公开号：US20050059730A1

  公开（公告）日：2005-03-17

  The present invention relates to a thiophene-containing compound and a thiophene-containing compound polymer which are useful for organo-electronic devices such as electrophotographic photoreceptors (photosensitive elements), organic electroluminescent elements and organic transistors. More specifically, the invention relates to a thiophene-containing compound and a thiophene-containing compound polymer which are excellent in terms of both charge-transporting properties and luminous properties.

  本发明涉及一种含噻吩的化合物和含噻吩的化合物聚合物，它们可用于有机电子器件，如电子照相感光体（感光元件），有机电致发光元件和有机晶体管。更具体地说，本发明涉及一种含噻吩的化合物和一种含噻吩的化合物聚合物，在电荷传输性能和发光性能方面均表现出优异的性能。
• CHEMICAL COMPOUNDS
  申请人：Cheung Mui

  公开号：US20070249600A1

  公开（公告）日：2007-10-25

  Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文描述了作为TIE-2和/或VEGFR2抑制剂有用的苯并咪唑衍生物。所述发明还包括制备这种苯并咪唑衍生物的方法，以及在治疗过度增生性疾病中使用它们的方法。