2-[(4-氨基苯甲酰基)氨基]-3-苯基丙酸 | 101399-39-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[(4-氨基苯甲酰基)氨基]-3-苯基丙酸
• 英文名称: N-p-Aminobenzoyl-L-phenylalanin
• 英文别名: N-(4-amino-benzoyl)-phenylalanine；N-(4-Amino-benzoyl)-phenylalanin；N-(4-Aminobenzoyl)phenylalanine；2-[(4-aminobenzoyl)amino]-3-phenylpropanoic acid
• CAS: 101399-39-7
• 化学式: C₁₆H₁₆N₂O₃
• 分子量: 284.315
• InChiKey: RZHDOMOYHYFIEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(4-氨基苯甲酰基)氨基]-3-苯基丙酸 在 硬脂醇聚醚-10 、 溶剂黄146 作用下， 生成 N-(4-amino-3,5-diiodo-benzoyl)-phenylalanine
  参考文献：
  名称：

  Archer et al., Journal of the American Pharmaceutical Association (1912), 1951, vol. 40, p. 143,144, 149

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-nitrobenzamido)-3-phenylpropanoic acid 在 乙醇 、 钯 作用下， 生成 2-[(4-氨基苯甲酰基)氨基]-3-苯基丙酸
  参考文献：
  名称：

  Analogs of Pteroylglutamic Acid. IV. Replacement of Glutamic Acid by Other Amino Acids

  摘要：

  DOI：

  10.1021/ja01177a019

文献信息

• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0178911A2

  公开（公告）日：1986-04-23

  57 Administration of an N-acylated amino acid (ornithine, lysine, phenylglycine or phenylalanine) in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. A pharmaceutical composition may be prepared simply by mixing the two components.

  57 将 N-酰化氨基酸（鸟氨酸、赖氨酸、苯甘氨酸或苯丙氨酸）与培南类或碳青霉烯类抗生素联合给药，可缓解或消除与单独给药抗生素相关的肾脏问题。 氨基酸和抗生素可一起配制成组合物，也可同时或依次单独给药。 只需将两种成分混合即可制备成药物组合物。
• Pyrimidine compounds and their use as pharmaceuticals
  申请人：Beiersdorf-Lilly GmbH

  公开号：EP0628559A1

  公开（公告）日：1994-12-14

  Pharmaceutical compounds which are azolo-fused pyrimidine compounds having the formula in which =A―B- together with the pyrimidine ring forms a) a pyrazolo[1,5-a]pyrimidine of formula (A), b) a [1,2,4]triazolo[1,5-a]pyrimidine of formula (B), c) an imidazo[1,5-a]pyrimidine of formula (C), or d) an imidazo[1,2-a]pyrimidine of formula (D),

  属于偶氮唑融合嘧啶化合物的药物化合物，其式为 其中 =A-B- 与嘧啶环一起形成 a) 式（A）的吡唑并[1,5-a]嘧啶、 b) 式（B）的[1,2,4]三唑并[1,5-a]嘧啶、 c) 式（C）的咪唑并[1,5-a]嘧啶、 或 d) 式（D）的咪唑并[1,2-a]嘧啶、
• Biocidal peptide and preparation based thereon
  申请人：“VERTA RESEARCH-PRODUCTION COMPANY” LTD

  公开号：US11059860B2

  公开（公告）日：2021-07-13

  The invention discloses peptides having biocidal properties, more particularly antibacterial, antifungal, and antiviral properties, and preparations based thereon. A biocidal peptide of general formula Y-Ile-Leu-Pro-X-Lys-X-Pro-X-X-Pro-X-Arg-Arg-NH2, where X is 4-nitrophenylalanine; 4-chlorophenylalanine; 4-methoxyphenylalanine; D-phenylalanine; 4-aminophenylalanine; 4-aminobenzoylphenylalanine; homophenylalanine; 4-tertbutylphenylalanine; 2-methylphenylalanine; 4-fluorophenyl alanine; pentafluorophenylalanine; or 2-trifluoromethylphenylalanine; and Y is H or palmitoyl or aminoundecanoyl, and a preparation in the form of a gel with biocidal properties, containing, as an active substance, the peptide at a concentration of 0.001 to 0.1 wt %. The peptides demonstrate biocidal properties towards bacteria, including spore-forming bacteria, mold fungi, and viruses. The peptide-based gels can be used for treating bacterial and viral infectious diseases and infectious comorbidities.

  本发明公开了具有杀菌特性，特别是抗菌、抗真菌和抗病毒特性的肽及其制剂。一种通式为Y-Ile-Leu-Pro-X-Lys-X-Pro-X-X-Pro-X-Arg-Arg-NH2的杀菌肽，其中X为4-硝基苯丙氨酸；4-氯苯丙氨酸；4-甲氧基苯丙氨酸；D-苯丙氨酸；4-氨基苯丙氨酸；4-氨基苯甲酰基苯丙氨酸；均苯丙氨酸；4-叔丁基苯丙氨酸；2-甲基苯丙氨酸；4-氟苯丙氨酸；五氟苯丙氨酸；或 2-三氟甲基苯丙氨酸；和 Y 是 H 或棕榈酰基或氨基十一酰基，以及具有杀生物特性的凝胶形式的制剂，该制剂作为活性物质含有浓度为 0.001 至 0.1 wt %。多肽对细菌（包括孢子形成细菌、霉菌和病毒）具有杀菌特性。肽基凝胶可用于治疗细菌和病毒感染性疾病以及传染性合并症。
• BIOCIDAL PEPTIDE AND PREPARATION BASED THEREON
  申请人："VERTA RESEARCH-PRODUCTION COMPANY" LTD

  公开号：US20200071358A1

  公开（公告）日：2020-03-05

  The invention relates to the field of medicine, in particular to novel peptides having biocidal properties, more particularly antibacterial, antifungal and antiviral properties, and preparations based thereon. Proposed are a biocidal peptide of general formula Y-Ile-Leu-Pro-X-Lys-X-Pro-X-X-Pro-X-Arg-Arg-NH2, where X is 4-nitrophenylalanine; 4-chlorophenylalanine; 4-methoxyphenylalanine; D-phenylalanine; 4-aminophenylalanine; 4-aminobenzoylphenylalanine; homophenylalanine; 4-tertbutylphenylalanine; 2-methylphenylalanine; 4-fluorophenyl alanine; pentafluorophenylalanine; or 2-trifluoromethylphenylalanine; and Y is H or palmitoyl or aminodecanoyl, and a preparation in the form of a gel with biocidal properties, containing, as an active substance, said peptide at a concentration of 0.001 to 0.1 wt %. The claimed peptides demonstrate biocidal properties towards bacteria, including spore-forming bacteria, mould fungi, and also viruses. The peptide-based gels can be used for treating bacterial and viral infectious diseases and infectious comorbidities.
• US4757066A
  申请人：——

  公开号：US4757066A

  公开（公告）日：1988-07-12