特托莫肽 | 915019-08-8

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 中文名称: 特托莫肽
• 英文名称: EARPALLTSRLRFIPK
• 英文别名: Glu-Ala-Arg-Pro-Ala-Leu-Leu-Thr-Ser-Arg-Leu-Arg-Phe-Ile-Pro-Lys；Tertomotide；(2S)-6-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]hexanoic acid
• CAS: 915019-08-8
• 化学式: C₈₅H₁₄₆N₂₆O₂₁
• 分子量: 1868.26
• InChiKey: WZJRQXZSYQYFJV-QAXVQDKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.6
• 重原子数：
  132
• 可旋转键数：
  60
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  779
• 氢给体数：
  25
• 氢受体数：
  26

反应信息

• 作为产物：
  描述：

  NH₂-Lys(Boc)-2-chloro-trityl resin 、 Fmoc-L-亮氨酸 、 Fmoc-L-丙氨酸 、 Fmoc-L-脯氨酸 、 Fmoc-L-苯丙氨酸 、 FMOC-O-叔丁基-L-丝氨酸 、 Fmoc-L-异亮氨酸 、 Fmoc-O-叔丁基-L-苏氨酸 、 Fmoc-Pbf-L-精氨酸 在 N-甲基吗啉 、 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.08h， 生成 特托莫肽
  参考文献：
  名称：

  피부 노화 개선용 조성물

  摘要：

  本说明书介绍了一种包含肽或其片段作为有效成分的用于预防或改善皮肤皱纹的化妆品。此外，本说明书还介绍了一种包含肽或其片段作为有效成分的用于改善皮肤老化的化妆品。

  公开号：

  KR102093093B1

文献信息

• Composition for Treating Prostate Cancer
  申请人：KIM Sang Jae

  公开号：US20160375091A1

  公开（公告）日：2016-12-29

  The present invention relates to a composition for treating prostate cancer and, more specifically, to a composition for treating prostate cancer, which contains a peptide derived from telomerase and is effective in inhibiting growth and metastasis of prostate cancer cells. In addition, the present invention provides a composition and method for treating prostate cancer, wherein, when prostate cancer is treated, docetaxel and the peptide derived from telomerase are co-administered, thereby having a synergetic therapeutic effect compared with administration alone. Particularly, the present invention provides a treatment method useful for patients who do not have a sufficient anticancer effect merely through administration of docetaxel alone and patients who have hormone resistance.

  本发明涉及一种用于治疗前列腺癌的组合物，更具体地说，涉及一种含有源自端粒酶的肽的前列腺癌治疗组合物，能有效抑制前列腺癌细胞的生长和转移。此外，本发明提供了一种治疗前列腺癌的组合物和方法，其中在治疗前列腺癌时，联合使用紫杉醇和源自端粒酶的肽，与单独使用相比具有协同治疗效果。特别是，本发明提供了一种治疗方法，适用于仅通过单独使用紫杉醇无法获得足够抗癌效果以及对激素产生抗性的患者。
• PEPTIDE FOR PREVENTING HEARING LOSS, AND COMPOSITION COMPRISING SAME
  申请人：GemVax & KAEL CO. LTD.

  公开号：US20180036384A1

  公开（公告）日：2018-02-08

  The present invention relates to a pharmaceutical composition for preventing and treating hearing loss. More particularly, the present invention relates to a composition including a telomerase-derived peptide, the composition being effective in the treatment and prevention of hearing loss due to an ototoxic drug. A peptide having a sequence of SEQ ID NO: 1, a peptide having 80% or more sequence homology to the sequence, or a fragment thereof, according to the present invention, has an excellent effect in the treatment and prevention of hearing loss due to an ototoxic drug.

  本发明涉及一种用于预防和治疗听力丧失的药物组合物。更具体地说，本发明涉及一种包括端粒酶衍生肽的组合物，该组合物对由耳毒性药物引起的听力丧失的治疗和预防具有有效性。根据本发明，具有SEQ ID NO: 1序列的肽、与该序列具有80%或更高序列同源性的肽，或其片段，在治疗和预防由耳毒性药物引起的听力丧失方面具有显著效果。
• PEPTIDE HAVING NEURONAL LOSS PREVENTION AND REGENERATION EFFECTS, AND COMPOSITION CONTAINING SAME
  申请人：GEMVAX & KAEL CO., LTD.

  公开号：US20180318383A1

  公开（公告）日：2018-11-08

  The present invention relates to a composition for neuronal loss prevention and regeneration and, more specifically, to a composition for neuronal loss prevention and regeneration, containing a telomerase-derived peptide so as to be effective on known diseases caused by neuronal loss and regeneration inability. According to the present invention, the peptide shows preventive and treatment effects on neuronal loss and regeneration inability diseases including Alzheimer's disease, and thus a novel method for treating neuronal loss and regeneration inability diseases can be provided.

  本发明涉及一种用于神经元损失预防和再生的组合物，更具体地说，涉及一种含有端粒酶衍生肽的神经元损失预防和再生组合物，以便对由神经元损失和再生障碍引起的已知疾病产生有效作用。根据本发明，该肽显示出对包括阿尔茨海默病在内的神经元损失和再生障碍疾病的预防和治疗作用，因此可以提供一种新的治疗神经元损失和再生障碍疾病的方法。
• 난소 동결 보존용 펩티드 및 이를 포함하는 조성물
  申请人：GemVax & KAEL CO.,LTD. 주식회사 젬백스앤카엘(119990428659) Corp. No ▼ 160111-0069636BRN ▼314-81-21219

  公开号：KR20150062502A

  公开（公告）日：2015-06-08

  본 발명은 난소 동결 보존용 펩티드 및 이를 포함하는 조성물에 관한 것으로, 보다 구체적으로는 텔로머라제로부터 유래된 펩티드 및/또는 라이코펜을 포함하는 난소 동결-해동시 또는 난소 동결 보존, 이식시 난소의 생존율을 향상시키는 조성물에 관한 것이다. 본 발명에 따르면 난소 동결 보존시 효과적으로 난소의 생존율을 향상시킬 수 있는 조성물이 제공될 수 있다. 최근 젊은 암 생존자의 증가와 결혼 및 초산연령의 늦어짐으로 인해 가임력 보존이 중요해지고 있어, 본 발명은 유용성은 점차 증가할 것으로 예상된다.

  本发明涉及用于卵巢冷冻保存的肽和含有它的组合物，更具体地说，涉及含有由端粒酶衍生的肽和/或番茄红素的卵巢冷冻-解冻或卵巢冷冻保存，移植时提高卵巢存活率的组合物。根据本发明，可以提供一种有效提高卵巢冷冻保存时卵巢存活率的组合物。由于近年来年轻癌症幸存者的增加、婚姻和初产年龄的推迟，生育能力的保存变得越来越重要，因此本发明的实用性预计将逐渐增加。
• 항노화 및 창상 치료용 펩티드 및 이를 포함하는 조성물
  申请人：GemVax & KAEL CO.,LTD. 주식회사 젬백스앤카엘(119990428659) Corp. No ▼ 160111-0069636BRN ▼314-81-21219

  公开号：KR20160010212A

  公开（公告）日：2016-01-27

  본 발명은 텔로머라제로부터 유래된 피부의 항노화 및 창상 치유에 효능을 갖는 펩티드, 그 펩티드를 포함하는 창상 치료 또는 피부 개선을 위해 사용되는 약학 조성물 및 그 조성물을 사용하는 창상 치료 또는 피부 개선 방법에 관한 것이다. 보다 구체적으로는 본 발명의 항노화 및 창상 치유 효능 펩티드 및 그를 포함하는 조성물을 피부에 적용하면, 섬유모세포의 이동이 증가하고, 콜라겐 생성이 촉진되며, 상피세포가 무결성을 가지며 증가 및 분화하게 되어 피부 상태를 호전 시키는데 있어서, 신속하고 뛰어난 효과를 얻을 수 있다.

  本发明涉及一种源自端粒酶的肽段，具有抗衰老和伤口愈合功效，以及用于伤口治疗或皮肤改善的药学组合物和使用该组合物的伤口治疗或皮肤改善方法。更具体地，当将本发明的抗衰老和伤口愈合肽段及其组合物应用于皮肤时，可以增加成纤维细胞的迁移，促进胶原生成，并使上皮细胞保持完整性并增加和分化，从而可以获得快速和出色的效果来改善皮肤状态。