降钙素,猪 | 12321-44-7

• 物质功能分类: 生物化工 - 多肽
• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 中文名称: 降钙素,猪
• 中文别名: 降钙素
• 英文名称: Calcitonin, porcine
• 英文别名: (4S)-4-[[(2S)-1-[2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-[[(2S,3R)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
• CAS: 12321-44-7
• 化学式: C₁₅₉H₂₃₄N₄₆O₄₅S₃
• 分子量: 3606.0
• InChiKey: FMPTWBWKJAJGSR-LJNLPFSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.9
• 重原子数：
  253
• 可旋转键数：
  112
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  1500
• 氢给体数：
  53
• 氢受体数：
  52

安全信息

• WGK Germany：
  3

文献信息

• Pharmaceutical compositions comprising a calcitonin and a glycyrrhizinate as absorption enhancer
  申请人：Smithkline Beecham Farmaceutici S.p.A.

  公开号：EP0327756A2

  公开（公告）日：1989-08-16

  The invention relates to pharmaceutical compositions comprising calcitonin and a glycyrrhizinate absorption enhancer. Preferred compositions are those adapted for nasal administration, for example nasal sprays.

  本发明涉及由降钙素和甘草酸盐吸收促进剂组成的药物组合物。优选的组合物是适用于鼻腔给药的组合物，例如鼻腔喷雾剂。
• PHARMACEUTICAL COMPOSITIONS
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0526524A1

  公开（公告）日：1993-02-10
• PREPARATION OF PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN
  申请人：Smithkline Beecham Farmaceutici S.p.A.

  公开号：EP0665755B1

  公开（公告）日：1998-07-01
• PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN
  申请人：Smithkline Beecham Farmaceutici S.p.A.

  公开号：EP0665755A1

  公开（公告）日：1995-08-09
• TRANSDERMAL DELIVERY SYSTEM FOR DRIED PARTICULATE OR LYOPHILIZED MEDICATIONS
  申请人：Stern Meir

  公开号：US20090137480A1

  公开（公告）日：2009-05-28

  The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.