9-p-Chlorobenzyl-8-isopropyl-1,2,3,4-tetrahydrocarbazol-1-yl-acetic acid | 121083-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-p-Chlorobenzyl-8-isopropyl-1,2,3,4-tetrahydrocarbazol-1-yl-acetic acid
• 英文别名: 2-(9-(4-chlorobenzyl)-8-isopropyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid；2-[9-[(4-chlorophenyl)methyl]-8-propan-2-yl-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid
• CAS: 121083-41-8
• 化学式: C₂₄H₂₆ClNO₂
• 分子量: 395.929
• InChiKey: YNLWPJVDHZFCOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(4-chlorobenzyl)-1-(2-isopropylphenyl)-hydrazine hydrochloride 生成 9-p-Chlorobenzyl-8-isopropyl-1,2,3,4-tetrahydrocarbazol-1-yl-acetic acid
  参考文献：
  名称：

  Tetrahydrocarbazoles for the improvement of cyclosporin therapy

  摘要：

  四氢咔唑，尤其是四氢咔唑-1-烷酸被披露。这些化合物对改善环孢霉素疗法有用。具体来说，这些化合物对限制环孢霉素诱导的肾毒性有用，包括在哺乳动物中同时给予有效剂量的环孢霉素和四氢咔唑-1-烷酸。

  公开号：

  EP0307077A1

文献信息

• Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
  申请人：Merck & Co., Inc.

  公开号：US04808608A1

  公开（公告）日：1989-02-28

  Tetrahydrocarbazole 1-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platlet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and as cytoprotective agents.

  本文披露了四氢咔唑-1-烷基酸。这些化合物作为前列腺素和血栓素拮抗剂，并且在治疗哮喘、腹泻、高血压、心绞痛、血小板聚集、脑痉挛、早产、自然流产和痛经以及作为细胞保护剂方面有用。
• Identification of an indole series of prostaglandin D2 receptor antagonists
  作者：Claudio F. Sturino、Nicolas Lachance、Michael Boyd、Carl Berthelette、Marc Labelle、Lianhai Li、Bruno Roy、John Scheigetz、Nancy Tsou、Christine Brideau、Elizabeth Cauchon、Marie-Claude Carriere、Danielle Denis、Gillian Greig、Stacia Kargman、Sonia Lamontagne、Marie-Claude Mathieu、Nicole Sawyer、Deborah Slipetz、Gary O’Neill、Zhaoyin Wang、Robert Zamboni、Kathleen M. Metters、Robert N. Young

  DOI：10.1016/j.bmcl.2006.02.062

  日期：2006.6

  A novel indole series of PGD(2) receptor (DP receptor) antagonists is presented. Optimization of this series led to the identification of potent and selective DP receptor antagonists. In particular, antagonists 35 and 36 were identified with K-i values of 2.6 and 1.8 nM, respectively. These two antagonists are also potent in a DIP functional assay where they inhibit the PGD(2) induced cAMP production in platelet rich plasma with IC50 values of 7.9 and 8.6 W, respectively. The structure-activity relationships of this indole series of DP receptor antagonists will also be discussed. (c) 2006 Elsevier Ltd. All rights reserved.
• Tetrahydrocarbazole esters
  申请人：MERCK FROSST CANADA INC.

  公开号：EP0239306B1

  公开（公告）日：1993-06-02
• US4808608A
  申请人：——

  公开号：US4808608A

  公开（公告）日：1989-02-28