2-[2-(2-羧基苯氧基)乙氧基]苯甲酸 | 17354-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[2-(2-羧基苯氧基)乙氧基]苯甲酸
• 英文名称: 1,2-bis(2-carboxyphenoxy)ethane
• 英文别名: 2,2'-<1,2-Ethandiylbis(oxy)>dibenzoesaeure；2,2'-ethanediyldioxy-di-benzoic acid；2,2'-Aethandiyldioxy-di-benzoesaeure；Aethylendisalicylsaeure；Aethylenglykol-bis-(2-carboxy-phenylaether)；2-[2-(2-Carboxyphenoxy)ethoxy]benzoic acid
• CAS: 17354-62-0
• 化学式: C₁₆H₁₄O₆
• 分子量: 302.284
• InChiKey: XAIPIJFEACIWEQ-UHFFFAOYSA-N

物化性质

• 熔点：
  150-153 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• 沸点：
  548.8±35.0 °C(Predicted)
• 密度：
  1.353±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[2-(2-羧基苯氧基)乙氧基]苯甲酸 在 氯化亚砜 、 sodium hydride 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 30.0h， 生成 8,11-dibutyl-5,6,7,8,9,10,16,17-octahydrodibenzo<1,4,8,11>dioxadiazacyclotetradecine-5,10-dione
  参考文献：
  名称：

  Efficient Synthesis of a Range of Benzo-Substituted Macrocyclic Diamides

  摘要：

  已经制备了16个新的14-17元大环二苯和三苯二氧二胺及三氧二胺（大环氧胺，例如5,6,7,8,9,10,16,17-八氢二苯[e,m][1,4,8,11]二氧二氮四癸因-5,10-二酮）13-28。在DMF中通过1,2-双(2-羟基苯甲酰胺基)乙烷6, 7和1,2-双(2-羟基苯甲酰胺基)苯8, 9的二钾盐与适当的二卤代烷或二甲磺酸酯反应，实现了13-28的大环化步骤，产率为40-90%。在THF和氢化钠中，通过13和25与适当的卤代化合物进行烷基化反应，得到了相应的N,N-二烷基大环氧胺29-33。后者的立体化学纯度通过1H NMR和13C NMR得到了证实。

  DOI：

  10.1055/s-1993-25893
• 作为产物：
  描述：

  1-甲基-2-[2-(2-甲基苯氧基)乙氧基]苯 在 potassium permanganate 、 四丁基硫酸氢铵 作用下， 以 水 为溶剂， 以7%的产率得到2-[2-(2-羧基苯氧基)乙氧基]苯甲酸
  参考文献：
  名称：

  Voegtle, Fritz; Kleiner, Thomas; Leppkes, Reinhard, Chemische Berichte, 1983, vol. 116, # 5, p. 2028 - 2034

  摘要：

  DOI：

文献信息

• [EN] NEW STEROID INHIBITORS OF PGP FOR USE FOR INHIBITING MULTIDRUG RESISTANCE<br/>[FR] NOUVEAUX INHIBITEURS STÉROÏDIENS DE PGP POUR EMPLOI DANS L'INHIBITION DE LA RÉSISTANCE PLÉIOTROPE
  申请人：INST NAT SANTE RECH MED

  公开号：WO2011073419A1

  公开（公告）日：2011-06-23

  The present invention relates to a compound of formula (I) for its use for reversing or inhibiting multidrug resistance.

  本发明涉及一种化合物，其化学式为(I)，用于逆转或抑制多药耐药。
• Anti-fouling Paints and Coatings
  申请人：Reactive Surfaces LTD

  公开号：US20150191607A1

  公开（公告）日：2015-07-09

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peptide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文披露了聚合材料，例如涂层、塑料、层压材料、复合材料、弹性体、粘合剂或密封剂；表面处理，例如纺织品整理或蜡；填充剂，用于这种聚合材料或表面处理，包括酯酶（例如脂肪水解酶、硫酸酯水解酶、有机磷化合物降解酶）的酶，降解细胞壁和/或细胞膜成分的酶（例如溶菌酶、裂解转葡糖苷酶），生物杀菌或生物稳定肽，和/或肽酶。本文还披露了通过将酶并入能够通过脂肪水解酶、水解酶和/或脲酶的活性进行化学交联的材料中，改变材料性能（例如使用寿命、柔韧性或刚度）的方法。
• Stretched film structure of the poly-1,3-phenylene terephthalate type
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0052927A2

  公开（公告）日：1982-06-02

  A monoaxially or biaxially stretched film structure, or a heat-set structure thereof, of an unstretched film of an aromatic polyester having an intrinsic viscosity, determined in p-chlorophenol at 50°C, of 0.4 to 2.0 and composed of [A] polybasic carboxylic acid component units consisting of terephthalic acid units (a1) and units (a2) of a polybasic carboxylic acid otherthan terephthalic acid, the proportion of the units (a2) being up to 25 mole% based on the units (a,) and units (a2) combined, and [B] polyol component units consisting of resorcinol units (b1) and units (b2) of a polyol other than resorcinol, the proportion of the units (b2) being up to 25 mole% based on the units (b1) and (b2) combined.

  一种单轴或双轴拉伸薄膜结构，或其热固结构，由芳香族聚酯的未拉伸薄膜组成，其固有粘度（在对氯苯酚中于 50℃测定）为 0.4 至 2.A] 由对苯二甲酸单元（a1）和对苯二甲酸以外的多基性羧酸单元（a2）组成的多基性羧酸组分单元，单元（a2）的比例为单元（a. ）和单元（a2）总和的 25 摩尔%、)和单元(a2)的总和，单元(a2)的比例不超过 25 摩尔%，以及 [B] 由间苯二酚单元(b1)和间苯二酚以外的多元醇单元(b2)组成的多元醇组分单 元，单元(b2)的比例不超过 25 摩尔%，单元(b1)和单元(b2)的总和。
• FLAME RETARDANT POLYESTER
  申请人：KANEBO, LTD.

  公开号：EP0731124A1

  公开（公告）日：1996-09-11

  A flame-retardant polyester comprising a thermoplastic polyester and, introduced thereinto, at least one flame-retardant component comprising phosphorus-containing dicarboxylic acid or diol units selected from among three components represented by the following general formula: in a phosphorus atom content of 0.2-3.0 wt.% based on the total weight, and mouldings thereof, such as fiber, film and resin moldings, wherein R represents alkyl, aryl or aralkyl; and X represents a group selected from among -R1COO-, OR2O-(-OC-A-COOR2O-)-a and -(-OR2-)-bO-A-O-(-R2O-)-c, wherein R1 represents alkylene bonded to the phosphorus atom, R2 represents C2-C4 alkylene, A represents a divalent aromatic residue, a=1-10, b=0-5, and c=0-5. The flame-retardant component has excellent heat resistance, does not sublime in the step of introducing the same into a high-temperaure polyester reaction system or during the molding of the polyester, is excellent in durability under repeated washing, light-fastness and whiteness, and does not deteriorate the properties inherent in thermoplastic polyester.

  一种阻燃聚酯，由热塑性聚酯和至少一种阻燃组分组成，阻燃组分包含从以下通式所代表的三种组分中选出的含磷二羧酸或二醇单元： 在磷原子含量为 0.2-3.0 wt.其中 R 代表烷基、芳基或芳烷基；和 X 代表选自-R1COO-、OR2O-(-OC-A-COOR2O-)-a 和-(-OR2-)-bO-A-O-(-R2O-)-c 的基团，其中 R1 代表与磷原子键合的亚烷基，R2 代表 C2-C4 亚烷基，A 代表二价芳香族残基，a=1-10，b=0-5 和 c=0-5。该阻燃剂成分具有优异的耐热性，在将其引入高温聚酯反应体系的步骤中或在聚酯成型过程中不会升华，在反复洗涤、耐光性和白度方面具有优异的耐久性，并且不会降低热塑性聚酯的固有特性。
• Benzohydroxamic acids as potent and selective anti-HCV agents
  作者：Maxim V. Kozlov、Alla A. Kleymenova、Lyudmila I. Romanova、Konstantin A. Konduktorov、Olga A. Smirnova、Vladimir S. Prasolov、Sergey N. Kochetkov

  DOI：10.1016/j.bmcl.2013.08.081

  日期：2013.11

  A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations. The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV. (C) 2013 Elsevier Ltd. All rights reserved.