2-carboxy-2'-nitrodiphenyl ether | 91804-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-carboxy-2'-nitrodiphenyl ether
• 英文别名: 2-(2-nitrophenoxy)benzoic acid；2-(2-nitro-phenoxy)-benzoic acid；2-(2-Nitro-phenoxy)-benzoesaeure；2-Nitro-2'-carboxydiphenylether
• CAS: 91804-44-3
• 化学式: C₁₃H₉NO₅
• 分子量: 259.218
• InChiKey: OTOXLRMIWPXHRC-UHFFFAOYSA-N

物化性质

• 熔点：
  154 °C
• 沸点：
  402.9±30.0 °C(Predicted)
• 密度：
  1.405±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-carboxy-2'-nitrodiphenyl ether 在 乙醇 、 硫酸 、 一水合肼 作用下， 反应 2.0h， 生成 1-hydroxy-benzotriazole tautomer
  参考文献：
  名称：

  Tomita; Ikawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 449,451

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-硝基苯氧基)甲苯 在 吡啶 、 potassium permanganate 作用下， 生成 2-carboxy-2'-nitrodiphenyl ether
  参考文献：
  名称：

  Tomita; Ikawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 449,451

  摘要：

  DOI：

文献信息

• Herringbone Helical Foldamers from Aromatic Ether Derived <i>ϵ</i>‐Amino Acid Peptides
  作者：Yong Yang、Min Xue

  DOI：10.1002/chem.202301832

  日期：2023.11.24

  A new type of herringbone helical foldamer based on a non-natural codon, i. e., aromatic ether derived ϵ-amino acid, was designed, synthesized and characterized. Attaching a single stereogenic carbon at the C-termini of the peptides induced single-handed screw sense, which was amplified through chain propagation.

  一种基于非天然密码子的新型人字形螺旋折叠体，即。例如，芳香族醚衍生的ε-氨基酸，被设计、合成和表征。在肽的 C 末端连接单个立体碳会诱导单手螺旋感觉，并通过链传播进行放大。
• New phenoxybenzoates, process for preparing these compounds, compositions containing them and method of use
  申请人：GAF CORPORATION

  公开号：EP0066106A1

  公开（公告）日：1982-12-08

  This invention relates to new phenoxybenzoates having high pre- and post- emergence herbicidal activity against indicator weeds; and are particularly effective against broadleaf weeds, such as morning glory. In addition to such effective herbicidal activity, they exhibit an unusual selectivity against important agromonic crops, such as cotton, rice, soybean, corn, wheat and sorghum.

  本发明涉及新型苯氧基苯甲酸酯，对指示性杂草具有很高的出苗前和出苗后除草活性；对阔叶杂草（如牵牛花）特别有效。除了这种有效的除草活性外，它们还对重要的农作物，如棉花、水稻、大豆、玉米、小麦和高粱表现出不同寻常的选择性。
• Process for preparing alpha,alpha-disubstituted aromatics and heteroaromatics as cognition enhancers
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：EP0532054A1

  公开（公告）日：1993-03-17

  Cognitive defeciencies or neurological dysfunction in mammals are treated with α,α-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: or a salt thereof    wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is α to at least one additional aromatic ring or heteroaromatic ring fused to the first ring;    one of Het¹ or Het² is 2, 3, or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected from (a) 2, 3, or 4-pyridyl, (b) 2, 4, or 5-pyrimidinyl, (c) 2-pyrazinyl, (d) 3, or 4-pyridazinyl, (e) 3, or 4-pyrazolyl, (f) 2, or 3-tetrahydrofuranyl, and (g) 3-thienyl.

  α，α-二取代芳香族或杂芳族化合物可治疗哺乳动物的认知缺陷或神经功能障碍。这些化合物的化学式如下 或其盐 其中 X 和 Y 共同形成饱和或不饱和碳环或杂环的第一环，所述环中所示碳与融 入第一环的至少一个附加芳环或杂芳环相连； Het¹ 或 Het² 中的一个是 2、3 或 4-吡啶基或 2、4 或 5-嘧啶基，另一个选自以下各项 (a) 2、3 或 4-吡啶基、 (b) 2、4 或 5-嘧啶基、 (c) 2-吡嗪基、 (d) 3 或 4-哒嗪基、 (e) 3 或 4-吡唑基、 (f) 2 或 3-四氢呋喃基，以及 (g) 3-噻吩基。
• Iodo Derivatives of Diphenyl Ether. I. The Mono- and Certain Diiodo-Derivatives of Diphenyl Ether, and of 2- and 4-Carboxy Diphenyl Ethers¹
  作者：R. Q. Brewster、Franklin Strain

  DOI：10.1021/ja01316a035

  日期：1934.1
• Expression of human hepatitis C virus core antigen in tobacco plants by tobacco mosaic virus-based vector system
  作者：Aidong Han、Yule Liu、Li Xiao、Liangyi Kang、Yuman Zhang、Dongtian Li、Bo Tian

  DOI：10.1007/bf02884901

  日期：2000.3

  Tobacco mosaic virus (TMV) has the potential to highly express foreign gene. A novel TMV-based in trans expression system was constructed. A TMV mutant TSHc had its coat protein replaced with hepatitis C virus (HCV) core antigen gene. Another TMV mutant TSBD was replicase-detective. Coinfection of the two mutants could cause systemic infection in tobacco plants by in trans complementation of their functions. TSHc could effectively replicate and assemble to viral particles, which were a little longer than that of wild-type TMV. HCV core antigen was expressed in whole tobacco plants. A similar expression lever of HCV core antigen was detected on serial passages, which suggested that this viral expression system be stable.