4-(diphenylphosphino)benzamide | 5068-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(diphenylphosphino)benzamide
• 英文别名: 4-Diphenyl-phosphino-benzamid；4-(Diphenylphosphino)benzamide；4-diphenylphosphanylbenzamide
• CAS: 5068-15-5
• 化学式: C₁₉H₁₆NOP
• 分子量: 305.316
• InChiKey: KZUACPSBACWLPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  4-(diphenylphosphino)benzamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以89%的产率得到4-(diphenylphosphino)benzylamine
  参考文献：
  名称：

  First Fluorescent Photoinduced Electron Transfer (PET) Reagent for Hydroperoxides

  摘要：

  graphicA novel fluorescent reagent for hydroperoxides, 4-(2-diphenylphosphinoethylamino)-7-nitro-2,1,3-benzoxadiazole (1), was developed on the basis of the method for designing photoinduced electron transfer (PET) reagents having a benzofurazan skeleton. Compound 1 was quantitatively reacted with hydroperoxides to give its fluorescent derivative, 2. In acetonitrile, the Phi value (0.44) of 2 was 31 times greater than that of 1. The long excitation (458 nm) and emission (520 nm) wavelengths of 2 are suitable for the determination of hydroperoxides, especially in biosamples.

  DOI：

  10.1021/ol0342150
• 作为产物：
  描述：

  4-二苯基膦苯甲酸 在 六氯环三磷腈 、 氨 作用下， 以 苯 、 水 、 乙腈 为溶剂， 反应 1.67h， 以56%的产率得到4-(diphenylphosphino)benzamide
  参考文献：
  名称：

  First Fluorescent Photoinduced Electron Transfer (PET) Reagent for Hydroperoxides

  摘要：

  graphicA novel fluorescent reagent for hydroperoxides, 4-(2-diphenylphosphinoethylamino)-7-nitro-2,1,3-benzoxadiazole (1), was developed on the basis of the method for designing photoinduced electron transfer (PET) reagents having a benzofurazan skeleton. Compound 1 was quantitatively reacted with hydroperoxides to give its fluorescent derivative, 2. In acetonitrile, the Phi value (0.44) of 2 was 31 times greater than that of 1. The long excitation (458 nm) and emission (520 nm) wavelengths of 2 are suitable for the determination of hydroperoxides, especially in biosamples.

  DOI：

  10.1021/ol0342150

文献信息

• [EN] METHODS, MEANS AND KITS FOR DETECTING SCARCE ANALYTES<br/>[FR] PROCÉDÉS, MOYENS ET COFFRETS POUR DÉTECTER DES ANALYTES PEU ABONDANTS
  申请人：UNIV GRONINGEN

  公开号：WO2013095137A2

  公开（公告）日：2013-06-27

  The invention relates methods, means and kits for detecting and quantitation of chemical and biological analytes using catalytic signal amplification. Provided are methods, kits, and reagents for detecting a target molecule or interacting target molecules in a sample based on catalytic signal amplification, comprising the steps of (i) providing at least a first non-fluorescent and a second non-fluorescent probe capable of binding to distinct binding sites on the target molecule(s), the first probe being provided with a first ligand and the second probe being provided with a second ligand, wherein the first and second ligand can form a catalytic complex in the presence of a catalytic compound and wherein the catalytic complex can catalyze a chromogenic reaction; (ii) contacting a sample known or suspected to contain the target molecule(s) with said at least a first and second non-fluorescent probe under conditions that allow for binding of the probes to the target molecule(s) such that, upon binding of the probes to the target molecule(s), the first and second ligand are brought in close proximity of each other and together with the catalytic compound form a catalytic complex immobilized on the target molecule(s); and (iii) detecting the formation of the catalytic complex based on a non-enzymatic conversion of a water- soluble precursor dye into a chromophoric reporter dye.
• First Fluorescent Photoinduced Electron Transfer (PET) Reagent for Hydroperoxides
  作者：Maki Onoda、Seiichi Uchiyama、Atsushi Endo、Hidetoshi Tokuyama、Tomofumi Santa、Kazuhiro Imai

  DOI：10.1021/ol0342150

  日期：2003.5.1

  graphicA novel fluorescent reagent for hydroperoxides, 4-(2-diphenylphosphinoethylamino)-7-nitro-2,1,3-benzoxadiazole (1), was developed on the basis of the method for designing photoinduced electron transfer (PET) reagents having a benzofurazan skeleton. Compound 1 was quantitatively reacted with hydroperoxides to give its fluorescent derivative, 2. In acetonitrile, the Phi value (0.44) of 2 was 31 times greater than that of 1. The long excitation (458 nm) and emission (520 nm) wavelengths of 2 are suitable for the determination of hydroperoxides, especially in biosamples.