6,7-dihydro-1H-indazole | 96228-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6,7-dihydro-1H-indazole
• 英文别名: 6,7-Dihydroindazole
• CAS: 96228-02-3
• 化学式: C₇H₈N₂
• 分子量: 120.154
• InChiKey: WGUGJYQCSHSHMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,5-Cyclohexadiene-1-carboxaldehyde Tosylhydrazone Sodium Salt 以86.8%的产率得到6,7-dihydro-1H-indazole
  参考文献：
  名称：

  Rearrangements of 1-cyclohexenylmethylenes and their relevance to the mechanism of the phenylcarbene rearrangement

  摘要：

  Gas-phase pyrolysis of 1-cyclohexenyldiazomethane (17) and (2-methyl-1-cyclohexenyl)diazomethane (36) leads to the generation of cyclohexenylmethylenes, 13 and 27, respectively, whose intramolecular rearrangement mechanisms can be inferred from the stable end products. These substituted vinylmethylenes undergo intramolecular pi-addition, but apparently do not participate in an all-carbon Wolff rearrangement. The relevance of these results to the mechanism of the phenylcarbene rearrangement is discussed, and it is suggested that a pi-route with a bicycloheptatriene-like transition state may operate. An attempt to generate 1,3-cyclohexadienylmethylene is described.

  DOI：

  10.1021/jo00017a021

文献信息

• 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：Fujii Akihito

  公开号：US20120059012A1

  公开（公告）日：2012-03-08

  Disclosed is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 is 1: a C 3-8 cycloalkyl C 1-4 alkyl group, 2: a C 7-14 aralkyl group, in which the aryl moiety thereof is optionally substituted with the same or different 1 to 3 groups selected from the group consisting of: (a) halogen, (b) C 1-4 alkyl, which is optionally substituted with 1 to 3 fluorine atoms, (c) C 1-4 alkoxy, which is optionally substituted with 1 to 3 fluorine atoms, and (d) C 1-4 alkylcarbonyl, which is optionally substituted with C 1-4 alkoxy, 3: a five- to ten-membered heteroaryl-C 1-4 alkyl group, in which the heteroaryl moiety thereof is optionally substituted with the same or different 1 to 3 groups selected from the group consisting of: (a) halogen, and (b) C 1-4 alkyl, or 4: a C 6-10 aryl C 2-6 alkenyl group; and R 2 is a cyano group or a nitro group.

  揭示了由化学式（I）表示的化合物或其药学上可接受的盐：其中R1是1：C3-8环烷基C1-4烷基基团，2：C7-14芳基烷基基团，其中其芳基部分可选择性地取代为来自以下组成的1至3个相同或不同的基团：(a)卤素，(b)C1-4烷基，可选择性地取代为1至3个氟原子，(c)C1-4烷氧基，可选择性地取代为1至3个氟原子，和(d)C1-4烷基羰基，可选择性地取代为C1-4烷氧基，3：五元至十元杂芳基-C1-4烷基基团，其中其杂芳基部分可选择性地取代为来自以下组成的1至3个相同或不同的基团：(a)卤素，和(b)C1-4烷基，或4：C6-10芳基C2-6烯基基团；和R2是氰基或硝基基团。
• Synthesis, thermolysis, and photolysis of the azoalkane 4,5-diazatricyclo[4.3.03,7]nona-4,8-diene: denitrogenation vs. azirane formation
  作者：Waldemar Adam、Karlheinz Hill

  DOI：10.1021/ja00298a044

  日期：1985.6
• Verfahren zur Herstellung von oberflächenmodifizierten Silicium-Nanopartikel
  申请人：Evonik Degussa GmbH

  公开号：EP2067743B1

  公开（公告）日：2013-07-10
• 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS
  申请人：Portola Pharmaceuticals, Inc.

  公开号：EP2323993B1

  公开（公告）日：2015-06-03
• Rearrangements of 1-cyclohexenylmethylenes and their relevance to the mechanism of the phenylcarbene rearrangement
  作者：Paula C. Miller、Peter P. Gaspar

  DOI：10.1021/jo00017a021

  日期：1991.8

  Gas-phase pyrolysis of 1-cyclohexenyldiazomethane (17) and (2-methyl-1-cyclohexenyl)diazomethane (36) leads to the generation of cyclohexenylmethylenes, 13 and 27, respectively, whose intramolecular rearrangement mechanisms can be inferred from the stable end products. These substituted vinylmethylenes undergo intramolecular pi-addition, but apparently do not participate in an all-carbon Wolff rearrangement. The relevance of these results to the mechanism of the phenylcarbene rearrangement is discussed, and it is suggested that a pi-route with a bicycloheptatriene-like transition state may operate. An attempt to generate 1,3-cyclohexadienylmethylene is described.