4,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxolane | 6316-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxolane
• CAS: 6316-64-9
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: IMENRMSTFPVGJX-UHFFFAOYSA-N

物化性质

• 沸点：
  282.7±15.0 °C(Predicted)
• 密度：
  0.986±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxolane 在 咪唑 、 2,6-二甲基吡啶 、 sodium periodate 、 四氧化锇 、 三氟化硼乙醚 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Cerium ammonium nitrate (CAN) for mild and efficient reagent to remove hydroxyethyl units from 2-hydroxyethyl ethers and 2-hydroxyethyl amines

  摘要：

  Cerium ammonium nitrate (CAN) removed hydroxyethyl units from 2-hydroxyethyl ethers and 2-hydroxyethyl amines to produce alcohols and amines in good yields. Especially, removal of the 2-hydroxyethyl ethers from C-2-symmetric diols, chiral 2,3-butanediol and chiral hydrobenzoin, was very useful for asymmetric syntheses using C-2-symmetric diols. The reactions using dual abilities of CAN, i.e., the ability for removal of the 2-hydroxyethyl unit and the ability for acetal hydrolysis by a single electron transfer, were also achieved Successfully. The reaction conditions were very mild and efficient, and many functional groups, which can be affected under normal conditions, were unaffected during the reaction. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2006.11.004
• 作为产物：
  描述：

  苯丙醛 、 2,3-丁二醇 在 Al-Fe pillared montmorillonite clay 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以99%的产率得到4,5-Dimethyl-2-(2-phenylethyl)-1,3-dioxolane
  参考文献：
  名称：

  AlFe柱撑蒙脱土催化缩醛

  摘要：

  AlFe柱状蒙脱石是在室温下在CH 2 Cl 2中制备缩醛的有效催化剂。

  DOI：

  10.1016/s0040-4020(97)10049-7

文献信息

• Methyl α,α-dichloro-esters by oxidation-chlorination of cyclic acetals with trichloroisocyanuric acid
  作者：Franco Bellesia、Monica Boni、Franco Ghelfi、Ugo M. Pagnoni

  DOI：10.1016/s0040-4039(00)76672-x

  日期：1994.5

  Methyl α-chloro- or α,α-dichloro-esters are obtained in excellent yields by oxidation chlorination of 2-alkyl-4,5-dimethyl-1,3-dioxolanes with trichloroisocyanuric acid.

  通过用三氯异氰尿酸氧化2-烷基-4,5-二甲基-1,3-二氧戊环，可以以优异的产率获得甲基α-氯-或α，α-二氯酯。
• Bellesia Franco, Boni Monica, Ghelfi Franco, Pagnoni Ugo M., Tetrahedron Lett, 35 (1994) N 18, S 2961-2964
  作者：Bellesia Franco, Boni Monica, Ghelfi Franco, Pagnoni Ugo M.

  DOI：——

  日期：——
• Acetals by AlFe-pillared montmorillonite catalysis
  作者：Maria Rita Cramarossa、Luca Forti、Franco Ghelfi

  DOI：10.1016/s0040-4020(97)10049-7

  日期：1997.11

  AlFe-pillared montmorillonite is an efficient catalyst for acetals preparation in CH2Cl2 at room temperature.

  AlFe柱状蒙脱石是在室温下在CH 2 Cl 2中制备缩醛的有效催化剂。
• Cerium ammonium nitrate (CAN) for mild and efficient reagent to remove hydroxyethyl units from 2-hydroxyethyl ethers and 2-hydroxyethyl amines
  作者：Hiromichi Fujioka、Hideki Hirose、Yusuke Ohba、Kenichi Murai、Kenji Nakahara、Yasuyuki Kita

  DOI：10.1016/j.tet.2006.11.004

  日期：2007.1

  Cerium ammonium nitrate (CAN) removed hydroxyethyl units from 2-hydroxyethyl ethers and 2-hydroxyethyl amines to produce alcohols and amines in good yields. Especially, removal of the 2-hydroxyethyl ethers from C-2-symmetric diols, chiral 2,3-butanediol and chiral hydrobenzoin, was very useful for asymmetric syntheses using C-2-symmetric diols. The reactions using dual abilities of CAN, i.e., the ability for removal of the 2-hydroxyethyl unit and the ability for acetal hydrolysis by a single electron transfer, were also achieved Successfully. The reaction conditions were very mild and efficient, and many functional groups, which can be affected under normal conditions, were unaffected during the reaction. (c) 2006 Published by Elsevier Ltd.