玫瑰树碱盐酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 玫瑰树碱盐酸盐
• 英文名称: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole;hydron;chloride
• 化学式: C17H15ClN2
• 分子量: 282.8
• InChiKey: VSBNVARERCGCEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.91
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  28.7
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
  申请人：The Scripps Research Institute

  公开号：EP2279243B1

  公开（公告）日：2016-01-06
• GENERATION OF PLURIPOTENT STEM CELLS USING RECOMBINANT PROTEINS
  申请人：Zhou Hongyan

  公开号：US20100233804A1

  公开（公告）日：2010-09-16

  The present invention provides for methods, compositions, and kits of producing an induced pluripotent stem cell from a mammalian non-pluripotent cell using exogenous transcription factors.
• ELLIPTICINE COMPOUNDS FOR TREATING OBESITY
  申请人：Ellies Debra

  公开号：US20100249171A1

  公开（公告）日：2010-09-30

  The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I: In Formula I, R 1 is H, C 1-6 alkyl, or C 1-6 alkyl-aryl. Each of R 2 and R 4 of Formula I are independently H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkoxy, —OR 2a , —SR 2a , —C(O)R 2a , —C(O)OR 2a , —C(O)NR 2a R 2b , —NR 2a R 2b , C 1-6 alkyl-NR 2a R 2b , —N(R 2a )C(O)R 2b , —N(R 2a )C(O)OR 2b , —N(R 2a )C(O)NR 2a R 2b , —OP(O)(OR 2a ) 2 , —S(O) 2 OR 2a , —S(O) 2 NR 2a R 2b , —CN, —NO 2 , cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each of R 2a and R 2b of Formula I are independently H, C 1-6 alkyl, C 1-10 heteroalkyl or C 1-6 alkyl-aryl. R 3 of Formula I is absent, C 1-6 alkyl or N-oxide. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.
• CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
  申请人：Shi Yan

  公开号：US20100267141A1

  公开（公告）日：2010-10-21

  The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
• Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells
  申请人：Shi Yan

  公开号：US20110110899A1

  公开（公告）日：2011-05-12

  The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.