6-(4-methoxyphenoxy)hexan-1-ol | 122004-89-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(4-methoxyphenoxy)hexan-1-ol
• 英文别名: 4-(6-hydroxyhexyloxy)anisole
• CAS: 122004-89-1
• 化学式: C₁₃H₂₀O₃
• 分子量: 224.3
• InChiKey: BSELTELBUPVXHY-UHFFFAOYSA-N

物化性质

• 沸点：
  359.3±22.0 °C(Predicted)
• 密度：
  1.031±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(4-methoxyphenoxy)hexan-1-ol 在 copper(l) iodide 、 periodic acid dihydrate 、 碘 、 三乙胺 、 三苯基膦 、 palladium dichloride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 25.0h， 生成 6-(5-((4-(docosyloxy)phenyl)ethynyl)-2-((4-(heptacosa-11,13,20,22-tetrayn-1-yloxy)phenyl)ethynyl)-4-methoxyphenoxy)hexan-1-ol
  参考文献：
  名称：

  Reactive two-component monolayers template bottom-up assembly of nanoparticle arrays on HOPG

  摘要：

  两种三苯基乙炔衍生物，1OH和2，在溶液-石墨(HOPG)界面自组装成有图案的单分子层(ML)。该单分子层用于模板自下而上在HOPG上自组装5 nm/19 nm双步距金纳米颗粒的形成。

  DOI：

  10.1039/c8cc04058c
• 作为产物：
  描述：

  6-氯-1-己醇 、 4-甲氧基苯酚 在 potassium carbonate 作用下， 以 水 、 二甲基亚砜 为溶剂， 生成 6-(4-methoxyphenoxy)hexan-1-ol
  参考文献：
  名称：

  Pharmaceutically active amines

  摘要：

  芳香胺（I），烷基胺（II），双环胺（III），环烷基胺（IV），芳香双环胺（V），氢醌胺（VI），醌胺（VII），氨基醚（VIII）和双环氨基醚（IX）可用作治疗多种疾病的药物，包括脊椎创伤、轻微和/或中度至严重头部损伤等。还公开了一种使用3,4-二氢苯并吡喯（XI）的治疗方法。

  公开号：

  US05120843A1

文献信息

• Chemoselective deoxygenation of ether-substituted alcohols and carbonyl compounds by B(C₆F₅)₃-catalyzed reduction with (HMe₂SiCH₂)₂
  作者：Wenyu Yang、Lu Gao、Ji Lu、Zhenlei Song

  DOI：10.1039/c8cc01163j

  日期：——

  B(C6F5)3-catalyzed deoxygenation of ether-substituted alcohols and carbonyl compounds has been developed using (HMe2SiCH2)2 as the reductant. This unique reagent shows distinct superiority over traditional one silicon-centered hydrosilanes, giving the corresponding alkanes in high yields with good tolerance of ethers, aryl halides and alkenes. The control experiments suggest that (HMe2SiCH2)2 might

  使用（HMe 2 SiCH 2）2作为还原剂，开发了B（C 6 F 5）3催化的醚取代的醇和羰基化合物的脱氧反应。这种独特的试剂显示出优于传统的以硅为中心的氢硅烷的独特优势，可高收率地提供相应的烷烃，并对醚，芳基卤化物和烯烃具有良好的耐受性。对照实验表明（HMe 2 SiCH 2）2可能以分子内Si / O活化方式促进该方法。
• Radical C(sp³)–H Heck-type Reaction of <i>N</i>-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols
  作者：Di Fang、Yidan Zhang、Yiyun Chen

  DOI：10.1021/acs.orglett.2c00593

  日期：2022.3.18

  the first radical C(sp3)–H Heck-type reaction of aliphatic alcohols for selective δ- and ε-alkenol synthesis by photoredox catalysis. N-Alkoxybenzimidoyl chlorides are developed as novel alkoxyl radical precursors with tunable redox potentials. Various alkenols can be constructed by the inert C(sp3)–H Heck-type reaction of 4-cyano-N-alkoxybenzimidoyl chlorides with styrene derivatives under redox-neutral

  我们报告了脂肪醇的第一个自由基 C(sp 3 )-H Heck 型反应，用于通过光氧化还原催化选择性合成 δ-和 ε-烯醇。N-烷氧基苯并亚胺酰氯被开发为具有可调氧化还原电位的新型烷氧基自由基前体。在氧化还原中性条件下，4-氰基-N-烷氧基苯并亚氨基酰氯与苯乙烯衍生物发生惰性 C(sp 3 )-H Heck 型反应可以构建各种烯醇，该反应可以在克级规模上进行，并且易于衍生化.
• POLY -AMINO ACID AND FERROELECTRIC MEMORY ELEMENT USING SAME
  申请人：Ajinomoto Co., Inc.

  公开号：EP2709147A1

  公开（公告）日：2014-03-19

  A ferroelectric memory element containing a poly α-amino acid which is a copolymer containing a glutamic acid-γ-ester unit represented by the formula (I): wherein R1 is a substituted or unsubstituted alkyl group having 1 - 8 carbon atoms, or a benzyl group optionally substituted by a halogen atom, an alkoxy group or a nitro group, and a glutamic acid-γ-ester unit represented by the formula (II) : wherein R2 is an unsubstituted alkyl group having 3 - 16 carbon atoms, or an alkyl group having 1 - 6 carbon wherein a part or all of hydrogen atom is substituted by a halogen atom, an alicyclic hydrocarbon group having 3 - 12 carbon atoms, an alkoxy group having 1 - 6 carbon atoms, a cyano group, a phenyl group (a part or all of hydrogen atom is optionally substituted by a halogen atom or an alkoxy group), a phenylalkoxy group (a part or all of hydrogen atom is optionally substituted by a halogen atom or an alkoxy group), or a phenylalkylcarbamate group (a part or all of hydrogen atom is optionally substituted by a halogen atom or an alkoxy group), provided that it is not the same as R1, wherein the content ratio of the unit of the formula (I) and the unit of the formula (II) ((I)/(II)) is 10/90 - 90/10 in a molar ratio.

  一种含有聚 α-氨基酸的铁电记忆元件，这种聚 α-氨基酸是含有由式 (I) 表示的谷氨酸-γ-酯单元的共聚物： 其中 R1 是具有 1 - 8 个碳原子的取代或未取代的烷基，或任选被卤素原子、烷氧基或硝基取代的苄基，以及 由式（II）代表的谷氨酸-γ-酯单元： 其中 R2 是具有 3 - 16 个碳原子的未取代烷基，或具有 1 - 6 个碳原子的烷基，其中部分或全部氢原子被卤素原子取代；具有 3 - 12 个碳原子的脂环烃基团；具有 1 - 6 个碳原子的烷氧基；氰基、苯基（部分或全部氢原子任选被卤素原子或烷氧基取代）、苯基烷氧基（部分或全部氢原子任选被卤素原子或烷氧基取代）或苯基烷基氨基甲酸酯基团（部分或全部氢原子任选被卤素原子或烷氧基取代），条件是它与 R1 不相同，其中 式（I）单元与式（II）单元的摩尔比（（I）/（II））为 10/90 - 90/10。
• PIEZOELECTRIC ELEMENT
  申请人：Ajinomoto Co., Inc.

  公开号：EP2816623A1

  公开（公告）日：2014-12-24

  Provided are poly(α-amino acid) showing superior piezoelectricity, which can be dissolved in various solvents, and a piezoelectric element containing the same. Specifically, a piezoelectric element containing poly(α-amino acid) containing (A) a glutamic acid γ-ester unit represented by the formula (I): and (B) one or more kinds of units selected from a glutamic acid γ-ester unit represented by the formula (II), an alanine unit, a phenylalanine unit and an Nε-benzyloxycarbonyllysine unit, which are represented by the formula (III), and a glutamic acid γ-ester unit represented by the formula (IV).

  本发明提供了具有优异压电性且可溶于各种溶剂的聚（α-氨基酸）以及含有该物质的压电元件。具体地说，一种含有聚（α-氨基酸）的压电元件，其含有 (A) 由式（I）表示的谷氨酸γ-酯单元：和 (B) 一种或多种单元，这些单元选自由式（II）表示的谷氨酸γ-酯单元、由式（III）表示的丙氨酸单元、苯丙氨酸单元和 Nε-苄氧羰基赖氨酸单元，以及由式（IV）表示的谷氨酸γ-酯单元。
• Design, Synthesis, and Biological Evaluation of <i>N</i>-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection
  作者：Wenquan Yu、Tina Gill、Lijuan Wang、Yanming Du、Hong Ye、Xiaowang Qu、Ju-Tao Guo、Andrea Cuconati、Kang Zhao、Timothy M. Block、Xiaodong Xu、Jinhong Chang

  DOI：10.1021/jm300171v

  日期：2012.7.12

  We recently described the discovery of oxygenated N-alkyl deoxynojirimycin (DNJ) derivative 7 (CM-10-18) with antiviral activity against dengue virus (DENY) infection both in vitro and in vivo. This imino sugar was promising but had an EC50 against DENY in BHK cells of 6.5 mu M, which limited its use in in vivo. Compound 7 presented structural opportunities for activity relationship analysis, which we exploited and report here. These structure activity relationship studies led to analogues 2h, 2l, 3j, 3l, 3v, and 4b-4c with nanomolar antiviral activity (EC50 = 0.3-0.5 mu M) against DENY infection, while maintaining low cytotoxicity (CC50 > 500 mu M, SI > 1000). In male Sprague-Dawley rats, compound 3l was well tolerated at a dose up to 200 mg/kg and displayed desirable PK profiles, with significantly improved bioavailability (F = 92 +/- 4%).