3-(methylsulfanyl)propanoic acid potassium salt | 352518-42-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(methylsulfanyl)propanoic acid potassium salt
• 英文别名: Potassium;3-methylsulfanylpropanoate
• CAS: 352518-42-4
• 化学式: C₄H₇O₂S*K
• 分子量: 158.263
• InChiKey: YYRKEQOFAFKCDN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.51
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  65.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙二胺氯化铂(II) 、 3-(methylsulfanyl)propanoic acid potassium salt 在 silver nitrate 、 silver carbonate 作用下， 以 水 为溶剂， 以90%的产率得到(ethylenediamine)[3-(methylsulfanyl)propanoato]platinum(II) nitrate
  参考文献：
  名称：

  Cisplatin analogues with sulfur donor ligands. (Ethylenediamine)platinum(II) complexes with ligands possessing a sulfinyl or sulfanyl group linked to an anionic oxygen donor atom. Reactivity and cytotoxicity

  摘要：

  Complexes of formula [Pt(en)L]NO3, where en = ethylenediamine and L is a ligand in which a methylsulfinyl or methylsulfanyl group is linked to a carboxylate or phenolate moiety, have been synthesized and characterized by spectroscopic techniques. The ligand L is chelated to Pt via the sulfur and anionic oxygen atoms. The reactivities of these complexes towards nucleophiles [Nu = Cl- or guanosine 5'-monophosphate(2-), GMP] have been investigated by H-1 NMR spectroscopy; GMP is more reactive than Cl-. The Pt-O bonds react more readily than the Pt-S bonds and, depending on the nature of L and Nu, the reactions either stop at the monosubstituted complex [Pt(en)L(Nu)] (with L monodentate and co-ordinated to Pt via the sulfur atom), or yield [Pt(en)(Nu)2]. The complex with L = 2-(methylsulfanyl)phenolate is unreactive. The stable monosubstituted products have been characterized. There is little correlation between the rates and the modes of reactivity of complexes [Pt(en)L]NO3 towards GMP and their cytotoxicities against the human ovarian carcinoma A2780 cell line.

  DOI：

  10.1039/dt9950000579

文献信息

• Cisplatin analogues with sulfur donor ligands. (Ethylenediamine)platinum(II) complexes with ligands possessing a sulfinyl or sulfanyl group linked to an anionic oxygen donor atom. Reactivity and cytotoxicity
  作者：Alessandro Pasini、Paola Perego、Massimo Balconi、Mauro Lupatini

  DOI：10.1039/dt9950000579

  日期：——

  Complexes of formula [Pt(en)L]NO3, where en = ethylenediamine and L is a ligand in which a methylsulfinyl or methylsulfanyl group is linked to a carboxylate or phenolate moiety, have been synthesized and characterized by spectroscopic techniques. The ligand L is chelated to Pt via the sulfur and anionic oxygen atoms. The reactivities of these complexes towards nucleophiles [Nu = Cl- or guanosine 5'-monophosphate(2-), GMP] have been investigated by H-1 NMR spectroscopy; GMP is more reactive than Cl-. The Pt-O bonds react more readily than the Pt-S bonds and, depending on the nature of L and Nu, the reactions either stop at the monosubstituted complex [Pt(en)L(Nu)] (with L monodentate and co-ordinated to Pt via the sulfur atom), or yield [Pt(en)(Nu)2]. The complex with L = 2-(methylsulfanyl)phenolate is unreactive. The stable monosubstituted products have been characterized. There is little correlation between the rates and the modes of reactivity of complexes [Pt(en)L]NO3 towards GMP and their cytotoxicities against the human ovarian carcinoma A2780 cell line.