(E)-cinnamyl 2-ethylphenyl ether | 1610349-69-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-cinnamyl 2-ethylphenyl ether
• 英文别名: 1-ethyl-2-[(E)-3-phenylprop-2-enoxy]benzene
• CAS: 1610349-69-3
• 化学式: C₁₇H₁₈O
• 分子量: 238.329
• InChiKey: MSXSQBISGCAOMQ-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.34
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  乙基苯酚 在 potassium phosphate 、 dichloro(cycloocta-1,5-diene)palladium (II) 、 四丁基溴化铵 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 28.0h， 生成 (E)-cinnamyl 2-ethylphenyl ether
  参考文献：
  名称：

  从芳族卤化物，酚和烯丙基氯化物高效钯催化合成肉桂醚

  摘要：

  AbstractA one‐pot, two‐step catalytic protocol for the preparation of cinnamyl ethers from simple and readily available aryl halides, phenols and allyl chloride is reported for the first time. This simple and highly efficient palladium nanoparticles catalytic system shows good regio‐ and stereoselectivities and affords the desired products in good to high yields (49–85%) from aryl iodides. Furthermore, less reactive aryl bromides can also give the cinnamyl ethers in moderate yields (24–72%).magnified image

  DOI：

  10.1002/adsc.201300757

文献信息

• An Efficient Palladium-Catalyzed Synthesis of Cinnamyl Ethers from Aromatic Halides, Phenols, and Allylic Chloride
  作者：Wei Wang、Rong Zhou、Zhi-Jie Jiang、Kun Wang、Hai-Yan Fu、Xue-Li Zheng、Hua Chen、Rui-Xiang Li

  DOI：10.1002/adsc.201300757

  日期：2014.2.10

  AbstractA one‐pot, two‐step catalytic protocol for the preparation of cinnamyl ethers from simple and readily available aryl halides, phenols and allyl chloride is reported for the first time. This simple and highly efficient palladium nanoparticles catalytic system shows good regio‐ and stereoselectivities and affords the desired products in good to high yields (49–85%) from aryl iodides. Furthermore, less reactive aryl bromides can also give the cinnamyl ethers in moderate yields (24–72%).magnified image