2-(3-(2-bromoethoxy)phenoxy)ethanol | 1392295-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(3-(2-bromoethoxy)phenoxy)ethanol
• 英文别名: 2-[3-(2-Bromoethoxy)phenoxy]ethanol；2-[3-(2-bromoethoxy)phenoxy]ethanol
• CAS: 1392295-09-8
• 化学式: C₁₀H₁₃BrO₃
• 分子量: 261.115
• InChiKey: SFXFGBCRHUEZCO-UHFFFAOYSA-N

物化性质

• 沸点：
  371.9±27.0 °C(Predicted)
• 密度：
  1.441±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-(2-bromoethoxy)phenoxy)ethanol 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 potassium iodide 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 192.0h， 生成 methylviologen-rhodamine dyad
  参考文献：
  名称：

  Fluorescence-On Response via CB7 Binding to Viologen–Dye Pseudorotaxanes

  摘要：

  Fluorescence-on sensors typically rely on disrupting photoinduced electron transfer quenching of the excited state through binding the electron donor. To provide a more general fluorescence-on signaling unit, a quencher-fluorophore dyad has been developed in which quenching by electron transfer to a tethered viologen acceptor can be disrupted through complexation of the viologen by cucurbit[7]uril (CB7). Dyads of benzyl viologen-rhodamine B or a BODIPY fluorophore gave upon CB7 complexation 14- and 30-fold fluorescence enhancement, respectively.

  DOI：

  10.1021/ol300963c
• 作为产物：
  描述：

  O-(2-hydroxyethyl)resorcinol 、 1,2-二溴乙烷 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 72.0h， 以57%的产率得到2-(3-(2-bromoethoxy)phenoxy)ethanol
  参考文献：
  名称：

  Fluorescence-On Response via CB7 Binding to Viologen–Dye Pseudorotaxanes

  摘要：

  Fluorescence-on sensors typically rely on disrupting photoinduced electron transfer quenching of the excited state through binding the electron donor. To provide a more general fluorescence-on signaling unit, a quencher-fluorophore dyad has been developed in which quenching by electron transfer to a tethered viologen acceptor can be disrupted through complexation of the viologen by cucurbit[7]uril (CB7). Dyads of benzyl viologen-rhodamine B or a BODIPY fluorophore gave upon CB7 complexation 14- and 30-fold fluorescence enhancement, respectively.

  DOI：

  10.1021/ol300963c

文献信息

• Fluorescence-On Response via CB7 Binding to Viologen–Dye Pseudorotaxanes
  作者：Anuradha Singh、Wai-Tak Yip、Ronald L. Halterman

  DOI：10.1021/ol300963c

  日期：2012.8.17

  Fluorescence-on sensors typically rely on disrupting photoinduced electron transfer quenching of the excited state through binding the electron donor. To provide a more general fluorescence-on signaling unit, a quencher-fluorophore dyad has been developed in which quenching by electron transfer to a tethered viologen acceptor can be disrupted through complexation of the viologen by cucurbit[7]uril (CB7). Dyads of benzyl viologen-rhodamine B or a BODIPY fluorophore gave upon CB7 complexation 14- and 30-fold fluorescence enhancement, respectively.