2-amino-D,L-eicosanoicacid | 115791-71-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-amino-D,L-eicosanoicacid
• 英文别名: 2-amino-eicosanoic acid；α-Amino-arachinsaeure；2-Amino-eikosansaeure-(1)；2-Amino-eicosansaeure；2-Amino-icosanoic acid；2-aminoicosanoic acid
• CAS: 115791-71-4
• 化学式: C₂₀H₄₁NO₂
• 分子量: 327.551
• InChiKey: NHWDPCHMQMJMRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-D,L-eicosanoicacid 在 N-甲基吗啉 、 甲醇 、 氯化亚砜 、 三氟化硼乙醚 、 盐酸羟胺 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 (R)-2-Amino-icosanoic acid methyl ester
  参考文献：
  名称：

  Gibbons, William A.; Hughes, Richard A.; Charalambous, Mario, Liebigs Annalen der Chemie, 1990, # 12, p. 1175 - 1183

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 氨 作用下， 生成 2-amino-D,L-eicosanoicacid
  参考文献：
  名称：

  Baczewski, Monatshefte fur Chemie, 1896, vol. 17, p. 544

  摘要：

  DOI：

文献信息

• Structure–activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates
  作者：Amy Chan、Waleed M. Hussein、Khairunnisa Abdul Ghaffar、Nirmal Marasini、Ahmed Mostafa、Sharareh Eskandari、Michael R. Batzloff、Michael F. Good、Mariusz Skwarczynski、Istvan Toth

  DOI：10.1016/j.bmc.2016.03.063

  日期：2016.7

  in a range of different illnesses, some of which are fatal. Currently, our efforts to develop a vaccine against GAS focuses on the lipid core peptide (LCP) system, a subunit vaccine containing a lipoamino acid (LAA) moiety which allows the stimulation of systemic antibody activity. In the present study, a peptide (J14) representing the B-cell epitope from the GAS M protein was incorporated alongside

  感染A组链球菌（GAS）可能导致一系列不同的疾病，其中一些是致命的。当前，我们开发抗GAS疫苗的工作集中在脂质核心肽（LCP）系统上，该系统是一种含有可刺激全身抗体活性的脂氨基酸（LAA）部分的亚单位疫苗。在本研究中，代表GAS M蛋白B细胞表位的肽（J14）与通用T辅助表位（P25）并入了四个具有不同空间方向或LAA长度的LCP构建体中。通过结构活性研究，发现虽然LCP方向的改变对免疫刺激的作用较弱，但在鼠模型中，构建体中LAA侧链长度的增加会增加抗体反应。此外，用先导LCP构建体免疫的小鼠在整个五个月的过程中也能够维持抗体活性。这些发现突出了LAA部分在鼻内肽疫苗开发中的重要性，并证实了其侧链长度对结构的免疫原性有影响。
• LUBRICATING OIL ADDITIVE AND LUBRICATING OIL COMPOSITION FOR DIESEL ENGINES
  申请人：Kao Corporation

  公开号：EP0835924A1

  公开（公告）日：1998-04-15

  A lubricating oil additive for diesel engines comprising one or more members of carboxylic acids, metal salts of carboxylic acids, amine salts of carboxylic acids, and carboxylic acid amides, each having a substituted amino group or substituted amino groups in a molecule, wherein the substituted aminocarboxylic acid compounds have a function of dispersing water-containing calcium sulfate in an oil; and a lubricating oil composition for diesel engines including these lubricating oil additives for diesel engines. When the lubricating oil additives and the lubricating oil compositions for diesel engines of the present invention are added to the lubricating oil, the dispersion function of the water-containing calcium sulfate admixed in the lubricating oil is dramatically improved, and the dispersion functions in oil of the staining components, such as soots, sludges, and the like, mentioned above owned by the lubricating oil are enhanced, so that its detergency is dramatically improved. Therefore, it is made possible to lower the concentration in the amount of the metal-based detergent as well as to lengthen the service life of the lubricating oil.

  一种柴油发动机用润滑油添加剂，包括羧酸、羧酸的金属盐、羧酸的胺盐和羧酸酰胺中的一种或多种成分，每种成分的分子中都有一个或多个取代的氨基，其中取代的氨基羧酸化合物具有分散油中含水硫酸钙的功能；以及一种柴油发动机用润滑油组合物，包括这些柴油发动机用润滑油添加剂。将本发明的柴油发动机用润滑油添加剂和润滑油组合物添加到润滑油中后，掺入润滑油中的含水硫酸钙的分散功能得到显著改善，润滑油所拥有的上述沾污成分（如煤烟、淤泥等）在油中的分散功能得到增强，从而使其清净性得到显著改善。因此，可以降低金属基清洁剂的用量浓度，并延长润滑油的使用寿命。
• An active energy ray curable composition comprised of a maleimide derivative and a method for curing the said curable composition
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0878482A1

  公开（公告）日：1998-11-18

  Objects of the present invention are the provision of an active energy ray curable composition which can be cured in the absence of a photoinitiator, and which can also be cured at practical light intensities and irradiating energy, and a method for curing the said curable composition; in which the composition comprises a maleimide derivative represented by formula (1): wherein m and n each represent an integer of 1 to 5, and the total of m and n is 6 or smaller, R11 and R12 each represent a linking group selected from the group consisting of ① an alkylene group, ② an alicyclic group, ③ an arylalkylene group, and ④ a cycloalkylalkyene group, G1 and G2 each represent an ester linkage selected from the group consisting of -COO- and - OCO-, R2 represents a linking chain having an average molecular weight of 100 to 100,000 selected from the group consisting of (A) a (poly)ether linking chain and (B) a (poly)ester linking chain, in which at least one organic group selected from the group consisting of ① a straight chain alkylene group, ② a branched alkylene group, ③ an alkylene group having a hydroxyl group, ④ an alicyclic group, ⑤ an aryl group, and ⑥ an arylalkylene group is connected via at least one linkage selected from the group consisting of (a) an ether linkage and (b) an ester linkage.

  本发明的目的是提供一种在没有光引发剂的情况下也能固化，并能在实际光强度和辐照能量下固化的活性能量射线固化组合物，以及固化上述固化组合物的方法；其中，该组合物包括由式（1）表示的马来酰亚胺衍生物： 其中 m 和 n 分别代表 1 至 5 的整数，且 m 和 n 的总和为 6 或更小、 R11 和 R12 各代表一个连接基团，该连接基团选自①亚烷基、②脂环基、③芳基亚烷基和④环烷基炔基、 G1 和 G2 分别代表选自 -COO- 和 -OCO- 组成的组的酯连接、 R2 代表平均分子量为 100 至 100,000 的连接链，选自由 (A) (多)醚连接链和 (B) (多)酯连接链组成的组，其中至少有一个有机基团选自由以下组成的组 ① 直链亚烷基、支链亚烷基、③具有羟基的亚烷基、④脂环族基团、⑤芳基和⑥芳烷基，其中至少一个有机基团通过选自 (a) 醚键和 (b) 酯键的一种连接方式连接。
• Water compatible energy curable compositions containing maleimide derivatives
  申请人：Sun Chemical Corporation

  公开号：EP1666504A1

  公开（公告）日：2006-06-07

  Active water compatible energy curable compositions comprised of maleimide derivatives, water compatible resins and water which are capable of curing at a practical intensity and energy level and a method for curing same.

  由马来酰亚胺衍生物、水相容性树脂和水组成的活性水相容性能量固化组合物，能以实用的强度和能量水平固化，以及固化方法。
• 2-Aminohydroxamic acid derivatives as inhibitors of Bacillus cereus phosphatidylcholine preferred phospholipase C PC-PLCBc
  作者：Patricia González-Bulnes、Albert González-Roura、Daniel Canals、Antonio Delgado、Josefina Casas、Amadeu Llebaria

  DOI：10.1016/j.bmc.2010.10.031

  日期：2010.12

  Phosphatidylcholine preferring phospholipase C (PC-PLC) is an important enzyme that plays a key role in a variety of cellular events and lipid homoeostases. Bacillus cereus phospholipase C (PC-PLCBc) has antigenic similarity with the elusive mammalian PC-PLC, which has not thus far been isolated and purified. Therefore the discovery of inhibitors of PC-PLCBc is of current interest. Here, we describe the synthesis and biological evaluation of a new type of compounds inhibiting PC-PLCBc. These compounds have been designed by evolution of previously described 2-aminohydroxamic acid PC-PLCBc inhibitors that block the enzyme by coordination of the zinc active site atoms present in PC-PLCBc [Gonzalez-Roura, A.; Navarro, I.; Delgado, A.; Llebaria, A.; Casas, J. Angew. Chem. Int. Ed. 2004, 43, 862]. The new compounds maintain the zinc coordinating groups and possess an extra trimethylammonium function, linked to the hydroxyamide nitrogen by an alkyl chain, which is expected to mimic the trimethylammonium group of the phosphatidylcholine PC-PLCBc substrates. Some of the compounds described inhibit the enzyme with IC50's in the low micromolar range. Unexpectedly, the most potent inhibitors found are those that possess a trimethylammonium group but have chemically blocked the zinc coordinating functionalities. The results obtained suggest that PC-PLCBc inhibition is not due to the interaction of compounds with the phospholipase catalytic zinc atoms, but rather results from the inhibitor cationic group recognition by the PC-PLCBc amino acids involved in choline lipid binding. (C) 2010 Elsevier Ltd. All rights reserved.