methyl 3-(2-tert-butoxy-2-oxoethylamino)-2-(5-methylfuran-2-yl)imidazo[1,2-a]pyridine-7-carboxylate | 1032186-26-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 3-(2-tert-butoxy-2-oxoethylamino)-2-(5-methylfuran-2-yl)imidazo[1,2-a]pyridine-7-carboxylate
• 英文别名: Methyl 2-(5-methylfuran-2-yl)-3-[[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]imidazo[1,2-a]pyridine-7-carboxylate
• CAS: 1032186-26-7
• 化学式: C₂₀H₂₃N₃O₅
• 分子量: 385.42
• InChiKey: KFCLAFYGBFLYIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  95.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 3-(2-tert-butoxy-2-oxoethylamino)-2-(5-methylfuran-2-yl)imidazo[1,2-a]pyridine-7-carboxylate 在 草酰氯 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 methyl 3-(2-(dipropylamino)-2-oxoethylamino)-2-(5-methylfuran-2-yl)imidazo[1,2-a]pyridine-7-carboxylate
  参考文献：
  名称：

  Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays

  摘要：

  Fluorescence imaging in clinical diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and molecular-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike molecules are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chemical libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent molecules. Because they are based upon a druglike scaffold, these fluorophores retain their molecular recognition potential and can be used to design specific imaging probes.

  DOI：

  10.1021/ja204016e
• 作为产物：
  描述：

  5-甲基呋喃醛 、 2-氨基异烟酸甲酯 、 异氰基乙酸叔丁酯 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以48%的产率得到methyl 3-(2-tert-butoxy-2-oxoethylamino)-2-(5-methylfuran-2-yl)imidazo[1,2-a]pyridine-7-carboxylate
  参考文献：
  名称：

  Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays

  摘要：

  Fluorescence imaging in clinical diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and molecular-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike molecules are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chemical libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent molecules. Because they are based upon a druglike scaffold, these fluorophores retain their molecular recognition potential and can be used to design specific imaging probes.

  DOI：

  10.1021/ja204016e

文献信息

• Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays
  作者：Olga N. Burchak、Laurent Mugherli、Mariano Ostuni、Jean Jacques Lacapère、Maxim Y. Balakirev

  DOI：10.1021/ja204016e

  日期：2011.7.6

  Fluorescence imaging in clinical diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and molecular-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike molecules are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chemical libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent molecules. Because they are based upon a druglike scaffold, these fluorophores retain their molecular recognition potential and can be used to design specific imaging probes.