N-pnenyl-N-(isopropoxymethyl)acetamide | 387818-20-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-pnenyl-N-(isopropoxymethyl)acetamide
• 英文别名: N-(isopropoxymethyl)acetanilide；Acetamide, N-[(1-methylethoxy)methyl]-N-phenyl-；N-phenyl-N-(propan-2-yloxymethyl)acetamide
• CAS: 387818-20-4
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: HLQHBJCLTSHLQO-UHFFFAOYSA-N

物化性质

• 沸点：
  289.2±23.0 °C(Predicted)
• 密度：
  1.050±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-乙酰苯胺 在 氢氧化钾 、 四丁基硫酸氢铵 、 对甲苯磺酸 作用下， 以 二甲基亚砜 为溶剂， 反应 2.5h， 生成 N-pnenyl-N-(isopropoxymethyl)acetamide
  参考文献：
  名称：

  SIMPLE SYNTHESIS OFN-ALKOXYMETHYL DERIVATIVES OF ANILIDES

  摘要：

  Facile, two-step synthesis of N-alkoxymethyl derivatives of anilides consisting of the methoxymethylation of the appropriate anilides with chlomethyl methyl ether followed by heating with an alcohol in the presence of an acid is described.

  DOI：

  10.1081/scc-100105679

文献信息

• N-Alkoxymethylation of Carboxamides Catalyzed by Brønsted Acids
  作者：Árpád Molnár、István Ledneczki、Pál M. Agócs

  DOI：10.1055/s-2003-42090

  日期：——

  The reaction of carboxamides and dialkoxymethanes can be affected by sulfonic acids (methanesulfonic acid, p-toluenesulfonic acid, and Nafion-H SAC-13 silica nanocomposite) to yield N-alkoxymethylcarboxamides. Various types of N-alkyl- and N-aryl-substituted acetamides can be reacted in a one-step procedure to give the products in moderate to good yields.

  羧酰胺与二烷氧基甲烷的反应可以受到磺酸（如美磺酸、对苯磺酸和Nafion-H SAC-13硅纳米复合材料）的影响，从而生成N-烷氧基甲羧酰胺。各种类型的N-烷基和N-芳基取代乙酰胺可以通过一步法反应，获得中等到良好的产率。
• Use of 2,4-disubstituted-5-thiazolecarboxylic acids and derivatives for reducing injury to crop plants by acetamide herbicides
  申请人：MONSANTO COMPANY

  公开号：EP0064353A1

  公开（公告）日：1982-11-10

  2,4-Disubstituted-5-thiazolecarboxylic acids and derivatives thereof have been found to reduce herbicidal injury of corn, rice and sorghum plants due to the application thereto of an acetamide herbicide selected from the ethyl ester of N-chloroacetyl-N-(2,6-diethylphenyl) glycine; 2-chloro-2',3'-dimethyl-N-(isopropyl)acetanilide; 2-chloro-2',6'-dimethyl-N-(1-pyrazolymethyl)acetanilide; 2-chloro-6'-trifluoromethyl-N-(isopropoxymethyl)acetanilide; 2-chloro-2'-methyl-6'-trifluoromethyl-N-(isopropoxymethyl)-acetanilide; 2-chloro-2'-methyl-6'-methoxy-N-(isopropoxymethyl)acetanilide; 2-chloro-2'-methyl-6'-methoxy-N-(propoxymethyl)acetanilide; 2-chloro-2'-methyl-6'-ethoxy-N-(propoxymethyl)acetanilide; 2-chloro-2'-isobutoxy-6'-methyl-N-(propoxymethyl)acetanilide; 2-chloro-2'-isobutoxy-6'-ethyl-N-(ethoxymethyl)acetanilide; and 2-chloro-2'-methyl-6'-trifluoromethyl-N-(ethoxymethyl)acetanilide.

  已发现 2,4-二取代-5-噻唑羧酸及其衍生物可减少玉米、水稻和高粱植物因施用选自 N-氯乙酰基-N-(2,6-二乙基苯基)甘氨酸乙酯的乙酰胺类除草剂而受到的除草伤害；2-氯-2',3'-二甲基-N-(异丙基)乙酰苯胺； 2-氯-2',6'-二甲基-N-(1-吡唑甲基)乙酰苯胺； 2-氯-6'-三氟甲基-N-(异丙氧基甲基)乙酰苯胺；2-氯-2'-甲基-6'-三氟甲基-N-(异丙氧基甲基)乙酰苯胺2-氯-2'-甲基-6'-乙氧基-N-(丙氧基甲基)乙酰苯胺； 2-氯-2'-异丁氧基-6'-甲基-N-(丙氧基甲基)乙酰苯胺； 2-氯-2'-异丁氧基-6'-乙基-N-(乙氧基甲基)乙酰苯胺；以及 2-氯-2'-甲基-6'-三氟甲基-N-(乙氧基甲基)乙酰苯胺。
• 3,5-Bis (trifluoromethyl) phenoxy carboxylic acids and derivatives thereof
  申请人：MONSANTO COMPANY

  公开号：EP0088066B1

  公开（公告）日：1985-04-03
• [EN] ANTIDOTE COMPOSITION AND METHOD FOR USE OF THE COMPOSITION<br/>[FR] COMPOSITION PHYTOPROTECTRICE ET SON PROCEDE DE MISE EN OEUVRE
  申请人：——

  公开号：WO1996015667A2

  公开（公告）日：1996-05-30

  [EN] The invention relates to an antidote composition containing an N-phenylphthalimide derivative of formula (I), wherein R1, R2 and R3, which are the same or different, stand for hydrogen, halogen, C1-4alkyl or methoxycarbonyl group; and R4 and R5 together form an 1,2-phenylene, 1-cyclohexen-1,2-ylene or 4-cyclohexen-1,2-ylene group and, at least one herbicide from the class of chloro acetanilide, urea, uracil, thiolcarbamate, triazine sulfonylurea. N-phenyl phthalimide, pyridazinone and imidazolin derivates.
  [FR] Composition phytoprotectrice renfermant un dérivé de N-phénylphtalimide répondant à la formule (I), dans laquelle R1, R2 et R3, identiques ou différents, représentent hydrogène, halogène, alkyle C1-4 ou un groupe méthoxycarbonyle; et R4 et R5 forment ensemble un groupe 1,2-phénylène, 1-cyclohexén-1,2-ylène ou 4-cyclohexén-1,2-ylène, ainsi qu'au moins un herbicide de la classe des dérivés de chloro-acétanilide, d'urée, d'uracile, de thiolcarbamate, de triazine-sulfonylurée, de N-phényl-phtalimide, de pyridazinone et d'imidazoline.
• SIMPLE SYNTHESIS OF<i>N</i>-ALKOXYMETHYL DERIVATIVES OF ANILIDES
  作者：Witold Danikiewicz、Rafal Szmigielski

  DOI：10.1081/scc-100105679

  日期：2001.1

  Facile, two-step synthesis of N-alkoxymethyl derivatives of anilides consisting of the methoxymethylation of the appropriate anilides with chlomethyl methyl ether followed by heating with an alcohol in the presence of an acid is described.