2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide | 159780-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide
• 英文别名: 2-(1,3-dioxoisoindol-2-yl)-N-(1,1,1-trifluoro-2-hydroxy-4-methylpentan-3-yl)acetamide
• CAS: 159780-12-8
• 化学式: C₁₆H₁₇F₃N₂O₄
• 分子量: 358.317
• InChiKey: QECIOIYALWVANL-UHFFFAOYSA-N

物化性质

• 沸点：
  532.405±50.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.377±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 在 2,6-二甲基吡啶 、 lithium hydroxide 、 TEA 、 叠氮磷酸二苯酯 、 一水合肼 、 lithium iodide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 吡啶 、 乙醇 为溶剂， 120.0 ℃ 、133.32 Pa 条件下， 反应 70.0h， 生成 2-(3-Benzyloxycarbonylamino-4-carboxy-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide
  参考文献：
  名称：

  Nonpeptidic Inhibitors of Human Neutrophil Elastase. 7. Design, Synthesis, and in Vitro Activity of a Series of Pyridopyrimidine Trifluoromethyl Ketones

  摘要：

  Using molecular modeling and the information derived from X-ray crystal structures of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonpeptidic inhibitors of HNE, the pyridopyrimidine trifluoromethyl ketones (TFMKs). These bicyclic inhibitors were designed to extend the concept of the related pyridone trifluoromethyl ketones by incorporating a rigidly positioned carbonyl group to participate in a hydrogen bonding interaction with the backbone NH groups of Gly-218 and Gly-219 of the enzyme. In addition, the pyrimidine ring serves as a scaffold to vector substituents toward the S-5-S-4 subsites of the enzyme's extended binding pocket. Furthermore, the heteroatoms of the pyrimidine ring generally increase the aqueous solubility of the pyridopyrimidines relative to pyridone TFMKs. Pyridopyrimidine TFMKs containing a 6-phenyl substituent afforded potent inhibitors of elastase, and several inhibitors from this class of compounds possessed aqueous solubilities of > 0.1 mg/mL and K-i values of less than or equal to 10 nM.

  DOI：

  10.1021/jm950684z
• 作为产物：
  描述：

  邻苯二甲酰甘氨酸 、 3-amino-1,1,1-trifluoro-4-methyl-2-pentanol hydrochloride 在 N-甲基吗啉 、 氯甲酸异丁酯 作用下， 生成 2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide
  参考文献：
  名称：

  Nonpeptidic Inhibitors of Human Neutrophil Elastase. 7. Design, Synthesis, and in Vitro Activity of a Series of Pyridopyrimidine Trifluoromethyl Ketones

  摘要：

  Using molecular modeling and the information derived from X-ray crystal structures of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonpeptidic inhibitors of HNE, the pyridopyrimidine trifluoromethyl ketones (TFMKs). These bicyclic inhibitors were designed to extend the concept of the related pyridone trifluoromethyl ketones by incorporating a rigidly positioned carbonyl group to participate in a hydrogen bonding interaction with the backbone NH groups of Gly-218 and Gly-219 of the enzyme. In addition, the pyrimidine ring serves as a scaffold to vector substituents toward the S-5-S-4 subsites of the enzyme's extended binding pocket. Furthermore, the heteroatoms of the pyrimidine ring generally increase the aqueous solubility of the pyridopyrimidines relative to pyridone TFMKs. Pyridopyrimidine TFMKs containing a 6-phenyl substituent afforded potent inhibitors of elastase, and several inhibitors from this class of compounds possessed aqueous solubilities of > 0.1 mg/mL and K-i values of less than or equal to 10 nM.

  DOI：

  10.1021/jm950684z

文献信息

• FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS
  申请人：Zeneca Limited

  公开号：EP0649432A1

  公开（公告）日：1995-04-26
• US5532366A
  申请人：——

  公开号：US5532366A

  公开（公告）日：1996-07-02
• [EN] FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS<br/>[FR] DIPEPTIDES CONTENANT DU FLUOR EN TANT QU'INHIBITEURS DIRIGES CONTRE LES INHIBITEURS DE L'ELASTASE DE LEUCOCYTES HUMAINS
  申请人：ZENECA LIMITED

  公开号：WO1994001455A1

  公开（公告）日：1994-01-20

  (EN) The present invention relates to certain novel amide derivatives of formula (I) which are pyrido [3,4-d] pyrimidin-7-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.(FR) L'invention concerne certains nouveaux dérivés d'amides de formule (I) qui sont des pyrido [3,4-d] pyrimidine-7-ylacétamides constituant des inhibiteurs de l'élastase de leucocytes humains également connue sous le nom d'élastase de neutrophiles humains. Lesdits dérivés sont utilisés lorsque l'on désire obtenir ce type d'inhibition, comme outils de recherche dans des études pharmacologiques, diagnostiques et apparentées, et dans le traitement de maladies chez les mammifères dans lesquelles l'élastase de leucocytes humains est impliquée. L'invention se rapporte également à des intermèdes utiles dans la synthèse de ces dérivés d'amides, aux procédés de préparation desdits dérivés d'amides, à des compositions pharmaceutiques contenant lesdits dérivés d'amides et leurs procédés d'utilisation.
• Nonpeptidic Inhibitors of Human Neutrophil Elastase. 7. Design, Synthesis, and <i>in Vitro</i> Activity of a Series of Pyridopyrimidine Trifluoromethyl Ketones
  作者：Philip D. Edwards、Donald W. Andisik、Anne M. Strimpler、Bruce Gomes、Paul A. Tuthill

  DOI：10.1021/jm950684z

  日期：1996.1.1

  Using molecular modeling and the information derived from X-ray crystal structures of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonpeptidic inhibitors of HNE, the pyridopyrimidine trifluoromethyl ketones (TFMKs). These bicyclic inhibitors were designed to extend the concept of the related pyridone trifluoromethyl ketones by incorporating a rigidly positioned carbonyl group to participate in a hydrogen bonding interaction with the backbone NH groups of Gly-218 and Gly-219 of the enzyme. In addition, the pyrimidine ring serves as a scaffold to vector substituents toward the S-5-S-4 subsites of the enzyme's extended binding pocket. Furthermore, the heteroatoms of the pyrimidine ring generally increase the aqueous solubility of the pyridopyrimidines relative to pyridone TFMKs. Pyridopyrimidine TFMKs containing a 6-phenyl substituent afforded potent inhibitors of elastase, and several inhibitors from this class of compounds possessed aqueous solubilities of > 0.1 mg/mL and K-i values of less than or equal to 10 nM.