2H-Indol-2-one, 1,3-dihydro-5,6-dimethyl- | 100487-73-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2H-Indol-2-one, 1,3-dihydro-5,6-dimethyl-
• 英文别名: 5,6-dimethyl-1,3-dihydroindol-2-one
• CAS: 100487-73-8
• 化学式: C₁₀H₁₁NO
• 分子量: 161.2
• InChiKey: SJIANDNABPJQQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5,6-二甲基靛红 生成 2H-Indol-2-one, 1,3-dihydro-5,6-dimethyl-
  参考文献：
  名称：

  KADIN, SAUL B.

  摘要：

  DOI：

文献信息

• Spiroindolinone Derivatives
  申请人：Chen Li

  公开号：US20090163512A1

  公开（公告）日：2009-06-25

  There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein W, X, X′, Y, V, V′, A, B and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.

  提供的化合物具有以下公式和其药用可接受的盐、酯和对映体，其中W、X、X′、Y、V、V′、A、B和R如本文所述。这些化合物可用作抗增殖剂，特别是抗癌剂。
• DPP IV inhibitors
  申请人：——

  公开号：US20030130281A1

  公开（公告）日：2003-07-10

  The present invention relates to compounds of formula (I) 1 wherein R 1 , R 2 , and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

  本发明涉及以下式（I）的化合物： 其中R1、R2和X如描述和权利要求中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与DPP IV相关的疾病，如糖尿病，特别是非胰岛素依赖型糖尿病和糖耐量受损。
• DPP IV INHIBITORS
  申请人：Boehringer Markus

  公开号：US20070259925A1

  公开（公告）日：2007-11-08

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 , and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

  本发明涉及公式(I)的化合物，其中R1，R2和X如描述和权利要求中所定义，并且其药学上可接受的盐。该化合物对于治疗和/或预防与DPP IV相关的疾病有用，例如糖尿病，特别是非胰岛素依赖性糖尿病和糖耐量受损。
• 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
  申请人：PFIZER INC.

  公开号：EP0156603A2

  公开（公告）日：1985-10-02

  2-Oxindole-1-carboxamides of the formula: and their pharmaceutically acceptable base-salts, where X and Y are certain optional substituents or can be taken together to form certain ring structures; and R1 is alkyl, cycloalkyl, cycloalkenyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenoxyalkyl, (thiophenoxy) alkyl, naphthyl, bicyclo [2.2.1]heptan-2-yl, bicyclo [2.2.1]hept-5-en-2-yl or a group of the formula -(CH2)n-O-R° where n is 0, 1 or 2, Q is a divalent radical which is a specified heterocycle, and R° is H or alkyl. The compounds are useful as analgesic and anti-inflammatory agents. Also covered are certain intermediates useful in the preparation of the compounds (I), these intermediates having H in place of -CORI.

  式中的 2-吲哚-1-甲酰胺： 及其药学上可接受的碱基盐，其中 X 和 Y 是某些任选取代基，或可共同形成某些环结构；R1 是烷基、环烷基、环烯基、任选取代的苯基、任选取代的苯基烷基、任选取代的苯氧基烷基、（噻吩氧基）烷基、萘基、双环 [2.2.2.1]庚-2-基、双环[2.2.1]庚-5-烯-2-基或式-(CH2)n-O-R°的基团，其中 n 为 0、1 或 2，Q 为指定杂环的二价基，R° 为 H 或烷基。 这些化合物可用作镇痛剂和消炎剂。 此外，还包括某些用于制备化合物（I）的中间体，这些中间体中的 H 取代了-CORI。
• N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
  申请人：PFIZER INC.

  公开号：EP0164860A1

  公开（公告）日：1985-12-18

  Certain 2-oxindole-lcarboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted phenyl group, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and antiinflammatory agents in mammalian subjects. These 2-oxindole-lcarboxamide compounds are of particular value for ameliorating pain in human patients recovering from surgery or trauma, and alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and ostoarthritis, in human subjects. Certain 2-oxind ole-1-carboxamide compounds unsubstituted at C-3, but having a substituent on the carboxamide nitrogen, are useful as intermediates to the analgesic and antiinflammatory agents of the invention.

  某些 2-氧吲哚-甲酰胺化合物在 3 位上具有酰基取代基，在羧酰胺氮上还进一步被烷基、环烷基、苯基或取代苯基取代，是环氧化酶（CO）和脂氧合酶（LO）的抑制剂，可用作哺乳动物的镇痛剂和抗炎剂。这些 2-氧化吲哚-甲酰胺化合物对于改善手术或创伤后恢复期人类患者的疼痛，以及减轻人类慢性疾病（如类风湿性关节炎和骨关节炎）的症状具有特殊价值。 某些在 C-3 处未被取代但在羧酰胺氮上具有取代基的 2-氧代吲哚-1-甲酰胺化合物可作为本发明镇痛剂和抗炎剂的中间体。