环丁烷四甲酸二酐 | 4415-87-6

• 物质功能分类: 化学试剂 - 有机试剂 - 羧酸酐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 环丁烷四甲酸二酐
• 中文别名: 1,2,3,4-环丁四甲酸二酐；1,2,3,4-环丁四羧二酐；环丁烷四酸二酐
• 英文名称: cyclobutanetetracarboxylic dianhydride
• 英文别名: 1,2,3,4-cyclobutanetetracarboxylic dianhydride；cyclobutane-1,2,3,4-tetracarboxylic dianhydride；Cyclobutan-1,2,3,4-tetracarbonsaeure-dianhydrid；4,9-dioxatricyclo[5.3.0.02,6]decane-3,5,8,10-tetrone
• CAS: 4415-87-6
• 化学式: C₈H₄O₆
• mdl: MFCD00004944
• 分子量: 196.116
• InChiKey: YGYCECQIOXZODZ-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C (lit.)
• 沸点：
  545.3±50.0 °C(Predicted)
• 密度：
  1.823±0.06 g/cm3(Predicted)
• 溶解度：
  溶于甲苯
• 稳定性/保质期：
  在常温常压下稳定，是一种白色粉末。燃烧时会生成一氧化碳这种刺激性和有毒的气体。

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 危险等级：
  8
• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2932190090
• 包装等级：
  III
• 危险类别：
  8
• 危险品运输编号：
  1759
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  请将药品存放在避光、通风且干燥的地方，并密封保存。

SDS

Name:	1 2 3 4-Cyclobutanetetracarboxylicdianhydride 97% Material Safety Data Sheet
Synonym:	None known
CAS:	4415-87-6

Section 1 - Chemical Product MSDS Name:1 2 3 4-Cyclobutanetetracarboxylicdianhydride 97% Material Safety Data Sheet
Synonym:None known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
4415-87-6	1,2,3,4-Cyclobutanetetracarboxylicdian	97	224-577-5

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 4415-87-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: > 300 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H4O6
Molecular Weight: 196.0244

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 4415-87-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1,2,3,4-Cyclobutanetetracarboxylicdianhydride - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 4415-87-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 4415-87-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 4415-87-6 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途：

• 用于制备生物学和药理学中的活性分子试剂；
• 用于制备高性能有机薄膜晶体管中的光敏性聚酰亚胺材料；
• 用于聚酰亚胺光子设备的选择性交联。

反应信息

• 作为反应物：
  描述：

  环丁烷四甲酸二酐 在 吡啶 、 盐酸羟胺 作用下， 反应 0.25h， 生成 N,N'-二羟基-1,2,3,4-环丁烷四甲酰二亚胺
  参考文献：
  名称：

  BISIMIDE COMPOUND, ACID GENERATOR AND RESIST COMPOSITION EACH CONTAINING THE SAME, AND METHOD OF FORMING PATTERN FROM THE COMPOSITION

  摘要：

  公开号：

  EP1449833B1
• 作为产物：
  描述：

  1,2,3,4-环丁烷四羧酸 以 乙酸酐 为溶剂， 反应 24.0h， 以to obtain 1,2,3,4-cyclobutanetetracarboxylic dianhydride (573 g, 2.93 mol)的产率得到环丁烷四甲酸二酐
  参考文献：
  名称：

  Cyclobutanetetracarboxylate compound and preparation method thereof

  摘要：

  本发明提供一种环丁烷四羧酸酯化合物，其一般式为（I），以及其制备方法：其中R和R1的定义如规范中所述。

  公开号：

  US07402693B2

文献信息

• Inhibitors of squalene synthase and protein farnesyltransferase
  申请人：Abbott Laboratories

  公开号：US05831115A1

  公开（公告）日：1998-11-03

  The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

  当前发明提供了一种具有以下公式的化合物##STR1##或其药用可接受盐，这些化合物对于抑制蛋白质法尼基转移酶和癌基因蛋白Ras的法尼基化或抑制从头开始的角鲨烯产生从而抑制胆固醇生物合成是有用的，此外还提供了制备发明化合物以及在这些过程中有用的中间体的过程，一种药物组合物，以及使用这些化合物的方法。
• 液晶配向剂以及化合物
  申请人：JSR株式会社

  公开号：CN103571502B

  公开（公告）日：2016-05-04

  本发明提供一种液晶配向剂以及化合物，该液晶配向剂可提供维持交联剂的调配效果并且形成性能的均匀性优异的液晶配向膜，而且作为组合物的稳定性及印刷性优异。本发明的液晶配向剂的特征在于含有：(A)在分子内具有(a1)选自由羧基、氧杂环丙基、氧杂环丁基、羟基、硫醇基、氨基及(甲基)丙烯酸基所组成的组群中的至少一个基团以及(a2)至少一个酰亚胺环，且分子量为1,000以下的化合物；以及(B)聚合物。
• Inhibitors of protein farnesyltransferase and squalene synthase
  申请人：Abbott Laboratories

  公开号：US05631401A1

  公开（公告）日：1997-05-20

  The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

  本发明提供了一种化合物，其化学式为##STR1##或其药用可接受的盐，该化合物在抑制蛋白质法尼基转移酶和致癌基因蛋白Ras的法尼基化或抑制新生角鲨烯产生以致使胆固醇生物合成受到抑制方面具有用处，还提供了制备本发明化合物的方法，以及这些方法中有用的中间体，一种药物组合物和使用这种化合物的方法。
• Inhibitors of squalene synthetase and protein farnesyltransferase
  申请人：Abbott Laboratories

  公开号：US05783593A1

  公开（公告）日：1998-07-21

  The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.

  本发明提供了一种化合物的公式 ##STR1##，它抑制了角鲨烯合酶和胆固醇生物合成，并且在治疗高脂血症、动脉粥样硬化或真菌感染等方面具有用途，以及用于制备该发明化合物的方法、这些方法中有用的中间体，以及含有这些化合物的药物组合物。
• Methods for preparing arene-BIS (dicarboximide)-based semiconducting materials and related intermediates for preparing same
  申请人：Facchetti Antonio

  公开号：US20080177073A1

  公开（公告）日：2008-07-24

  The present teachings provide compounds of formulae I and II: where Q, R a , R 1 , W, and n are as defined herein. The present teachings also provide methods of preparing compounds of formulae I and II, including methods of preparing compounds of formula II from compounds of formula I. The compounds disclosed herein can be used to prepare semiconductor materials and related composites and electronic devices.

  本教学提供了符合以下公式I和II的化合物：其中Q、Ra、R1、W和n的定义如本文所述。本教学还提供了制备符合公式I和II的化合物的方法，包括从符合公式I的化合物制备符合公式II的方法。本文披露的化合物可用于制备半导体材料、相关复合材料和电子器件。

表征谱图