(Z)-(4-chlorostyryl)(4-methoxybenzyl)sulfane | 1243262-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Z)-(4-chlorostyryl)(4-methoxybenzyl)sulfane
• 英文别名: 1-chloro-4-[(Z)-2-[(4-methoxyphenyl)methylsulfanyl]ethenyl]benzene
• CAS: 1243262-44-3
• 化学式: C₁₆H₁₅ClOS
• 分子量: 290.813
• InChiKey: LMRFNSAHILVXIA-KHPPLWFESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯丙炔酸 、 4-甲氧基苄硫醇 在 copper(l) iodide 、 caesium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 生成 (Z)-(4-chlorostyryl)(4-methoxybenzyl)sulfane 、 (E)-(4-chlorostyryl)(4-methoxybenzyl)sulfane
  参考文献：
  名称：

  Synthesis of Vinyl Sulfides by Copper-Catalyzed Decarboxylative C−S Cross-Coupling

  摘要：

  A novel method for the synthesis of vinyl sulfides by the decarboxylative cross-coupling of arylpropiolic acids with thiols using copper(I) salts as catalysts has been developed. In the presence of Cul and Cs2CO3, a variety of thiols reacted with arylpropiolic acids to afford the corresponding vinyl sulfides in good to excellent yields with high stereoselectivity for Z-isomers.

  DOI：

  10.1021/ol101729k

文献信息

• Synthesis of Vinyl Sulfides by Copper-Catalyzed Decarboxylative C−S Cross-Coupling
  作者：Sadananda Ranjit、Zhongyu Duan、Pengfei Zhang、Xiaogang Liu

  DOI：10.1021/ol101729k

  日期：2010.9.17

  A novel method for the synthesis of vinyl sulfides by the decarboxylative cross-coupling of arylpropiolic acids with thiols using copper(I) salts as catalysts has been developed. In the presence of Cul and Cs2CO3, a variety of thiols reacted with arylpropiolic acids to afford the corresponding vinyl sulfides in good to excellent yields with high stereoselectivity for Z-isomers.