2-methyl-N-(oxiran-2-ylmethyl)propan-2-amine | 13080-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 2-methyl-N-(oxiran-2-ylmethyl)propan-2-amine
• 英文别名: tert-butyl-oxiranylmethylamine；tert-butyl-oxiranylmethyl-amine
• CAS: 13080-65-4
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: PZMYHLFQJXHHLD-UHFFFAOYSA-N

物化性质

• 沸点：
  54-55 °C(Press: 10 Torr)
• 密度：
  0.921±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-N-(oxiran-2-ylmethyl)propan-2-amine 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以85%的产率得到1-叔丁基-3-氮杂环丁醇
  参考文献：
  名称：

  通过 2,3-环氧丙胺的重排简便合成 Azetidin-3-ols

  摘要：

  在回流乙腈中处理三乙胺后，由伯烷基胺 (1) 和环氧氯丙烷形成的 N-烷基-2,3-环氧丙胺 (2) 被化学选择性地重排为四元环 N-烷基氮杂环丁烷-3-醇 (3) .

  DOI：

  10.1081/scc-120026859
• 作为产物：
  描述：

  叔丁胺 、 环氧氯丙烷 在 potassium hydroxide 作用下， 以 异丙醇 、 乙醚 为溶剂， 反应 25.5h， 以57%的产率得到2-methyl-N-(oxiran-2-ylmethyl)propan-2-amine
  参考文献：
  名称：

  受基质控制的产品差异：将CO2转化为杂环产品

  摘要：

  取代的环氧醇和胺可通过不同的机械歧管，将底物控制的CO 2转化为多种杂环结构。这种新方法通过胺或醇单元对CO 2的初始活化，导致了源自CO 2衍生产品的异常范围，从而在温和的反应条件下为分子内环氧开环提供了亲核试剂。对照实验通过遵循S N i途径的亲核试剂开环步骤和5-exo-tet环化作用，支持了胺/醇片段在该过程中的关键作用，从而形成了杂环骨架。

  DOI：

  10.1002/anie.201511521

文献信息

• Synthesis of Five-membered Heterocycles by Reactions of<i>N</i>-Substituted-2-aminomethyloxiranes with Heterocumulenes
  作者：Michinori Karikomi、Tohru Yamazaki、Takashi Toda

  DOI：10.1246/cl.1993.1965

  日期：1993.11

  Various five-membered heterocyclic compounds were synthesized by the reactions of N-substituted-2-aminomethyloxiranes with several different heterocumulenes in good yields.

  通过N-取代-2-氨基甲基环氧乙烷与几种不同的杂枯草烯以良好的产率反应合成了各种五元杂环化合物。
• E- and Z-Stereoselectivity in the preparation of enamides from glycidyl sulfonamides and carbamates
  作者：Jack A. Brown、Vijay Chudasama、Melvyn E. Giles、Duncan M. Gill、Philip S. Keegan、William J. Kerr、Rachel H. Munday、Karen Griffin、Andrew Watts

  DOI：10.1039/c1ob06569f

  日期：——

  Treatment of glycidyl sulfonamides with LDA delivers the corresponding enesulfonamide with good selectivity for the E-isomer, whereas the corresponding carbamates exhibit selectivity for the Z-enecarbamate. An E1cB elimination mechanism proceeding from a substrate–base chelate complex is advanced as rationalisation of the latter set of Z-selective outcomes.

  用LDA处理缩水甘油基磺酰胺可得到对E-异构体具有良好选择性的相应的烯磺酰胺，而相应的氨基甲酸酯对Z-烯氨基甲酸酯则具有选择性。随着对Z选择性结果的合理化，从底物-基螯合物开始的E1cB消除机制得到了发展。
• Stereoselective synthesis of 3-hydroxyazetidines via regioselective halogenation of 2,3-epoxyamines by using magnesium bromide
  作者：Michinori Karikomi、Kouji Arai、Takashi Toda

  DOI：10.1016/s0040-4039(97)01360-9

  日期：1997.8

  A novel stereoselective synthesis of 3-hydroxyazetidines starting from 2,3-epoxyamines is described. Regioselectivity of the intramolecular cyclization of 2,3-epoxyamines is controlled by the use of magnesium bromide. The cyclization proceeds with retention of the stereochemistry, caused by double inversion of two sequential SN2 reactions of the epoxyamines.

  描述了从2，3-环氧胺开始的3-羟基氮杂环丁烷的新颖的立体选择性合成。通过使用溴化镁来控制2，3-环氧胺的分子内环化的区域选择性。由于环氧胺的两个连续S N 2反应的两次反转，环化过程将保留立体化学。
• VINYL RESIN AND RESIN COMPOSITION
  申请人：SANYO CHEMICAL INDUSTRIES, LTD.

  公开号：US20150119497A1

  公开（公告）日：2015-04-30

  The present invention aims to provide a vinyl resin which, with a polyurethane resin, is capable of providing a film excellent in mechanical strength, weather resistance, solvent resistance, and water resistance. The vinyl resin (V1) of the present invention is obtainable by polymerizing monomer components including a monomer (X) represented by the formula (1): wherein M 1 is a hydroxy group or a residue of an active hydrogen-containing organic compound having a valence of 1 to 20 from which c number of active hydrogen atoms are removed; c is 1 if M 1 is a hydroxy group, or c is an integer satisfying 1≦c≦(valence of M 1 ) if M 1 is a residue of an active hydrogen-containing organic compound having a valence of 1 to 20 from which c number of active hydrogen atoms are removed; R 1 is an ethylenic unsaturated bond-containing group, and when the formula (1) includes multiple R1's, they may be the same as or different from each other; M 2 is a hydroxy group or a residue of an active hydrogen-containing organic compound having a valence of 1 to 20 from which one active hydrogen atom is removed, and when the formula (1) includes multiple M 2 's, they may be the same as or different from each other, and M 2 and M 1 may be the same as or different from each other; L is a residue of an aromatic polycarboxylic acid having 3 or more carboxyl groups from which all the carboxyl groups are removed, the aromatic ring of L is constituted by carbon atoms, and each of the carbon atoms may optionally have a halogen atom and/or a substituent which is not a carboxyl group, but at least one of the carbon atoms has a hydrogen atom; a and b are each an integer of 0 or greater and they satisfy 2≦(a+b)≦(d−2), when the formula (1) includes multiple a's, they may be the same as or different from each other and at least one of c number of a's is not 0, and when the formula (1) includes multiple b's, they may be the same as or different from each other; and d is the number of hydrogen atoms bonded to the carbon atoms constituting the aromatic ring assuming that all the substituents including the carboxyl groups of the aromatic polycarboxylic acid are replaced by hydrogen atoms, in other words, the number of moieties capable of being replaced by a substituent on the aromatic ring.

  本发明旨在提供一种乙烯基树脂，该树脂与聚氨酯树脂一起使用，能够提供机械强度、耐候性、耐溶剂性和耐水性优异的膜。本发明的乙烯基树脂（V1）可通过聚合单体组分获得，该组分包括由式（1）表示的单体（X）：其中M1是具有1到20个活性氢原子的具有价为1到20的活性氢含有机化合物的羟基或残基，从中去除了c个活性氢原子，则当M1是羟基时，c为1，或当M1是具有价为1到20的活性氢含有机化合物的残基时，c是满足1≤c≤（M1的价）的整数；R1是含有乙烯基不饱和键的基团，当式（1）包括多个R1时，它们可以相同或不同；M2是具有1到20个活性氢原子的具有价为1到20的活性氢含有机化合物的羟基或残基，从中去除了一个活性氢原子，当式（1）包括多个M2时，它们可以相同或不同，且M2和M1可以相同或不同；L是具有3个或更多羧基的芳香族多羧酸的残基，L的芳香环由碳原子构成，每个碳原子可以选择性地具有卤素原子和/或不是羧基的取代基，但至少有一个碳原子具有氢原子；a和b分别是大于或等于0的整数，它们满足2≤（a+b）≤（d-2），当式（1）包括多个a时，它们可以相同或不同，并且c个a中至少有一个不为0，当式（1）包括多个b时，它们可以相同或不同；d是假设芳香环上包括羧基的所有取代基都被氢原子取代的碳原子上结合的氢原子数，换句话说，是能够被芳香环上取代基替换的基团数。
• Substituted aryloxyamino-propanols and methods of preparing same
  申请人：SLOVENSKA AKADEMIA VIED

  公开号：EP0302694A2

  公开（公告）日：1989-02-08

  Betaadrenolytically effective substances consisting of 1-aryloxy-3-alkylamino-2-propanols of the general formula I wherein R¹ is alkyl with 3 to 4 carbon atoms, and R² is a ramified alkyl with 3 to 4 carbon atoms, such substances being prepared in a reaction in a polar solvent from (a) alkyl ester of 3-acetyl-4[(3-bromo-2-hydroxy)-propoxy]­phenylcarbamic acid with a primary alkylamine; (b) alkyl ester of 3-acetyl-4[(2-3,epoxy)-propoxy]phenyl­carbamic acid with a primary alkylamine in the medium of an alkanol with 1 to 3 carbon atoms; (c) alkyl ester of 3-acetyl-4-hydroxyphenylcarbamic acid with 1-alkylamino-2,3-epoxypropane, the reaction being catalyzed by an alkali metal hydroxide; and (d) alkyl ester of 3-acetyl-4-hydroxyphenylcarbamic acid with 1-alkylamino-3-chloro-2-propanol, the reaction being catalyzed by an alkali metal hydroxide.

  由通式 I 的 1-芳氧基-3-烷基氨基-2-丙醇组成的β-肾上腺素有效物质 其中 R¹ 为 3 至 4 个碳原子的烷基，R² 为 3 至 4 个碳原子的柱齿烷基，这类物质在极性溶剂中通过以下反应制备而成 (a) 3-乙酰基-4[(3-溴-2-羟基)-丙氧基]苯基氨基甲酸与伯胺的烷基酯； (b) 3-乙酰基-4[(2-3,环氧)-丙氧基]苯基氨基甲酸与一级烷基胺在 1 至 3 个碳原子的烷醇介质中的烷基酯； (c) 3-乙酰基-4-羟基苯基氨基甲酸与 1-烷基氨基-2,3-环氧丙烷的烷基酯，该反应由碱金属氢氧化物催化；及 (d) 3-乙酰基-4-羟基苯基氨基甲酸与 1-烷基氨基-3-氯-2-丙醇的烷基酯，该反应由碱金属氢氧化物催化。