trans-Hepten-(4)-carbonsaeure-(1) | 16424-53-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: trans-Hepten-(4)-carbonsaeure-(1)
• 英文别名: trans-delta-Octenoic acid；(E)-oct-5-enoic acid
• CAS: 16424-53-6
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: RRGOKSYVAZDNKR-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-Hepten-(4)-carbonsaeure-(1) 在 PPA 作用下， 生成 丙位辛内酯
  参考文献：
  名称：

  Riobe, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958, vol. 247, p. 1016

  摘要：

  DOI：
• 作为产物：
  描述：

  反式-3-己烯-1-醇 在 吡啶 、 氢氧化钾 、 乙醇 、 三溴化磷 作用下， 生成 trans-Hepten-(4)-carbonsaeure-(1)
  参考文献：
  名称：

  Unsaturated Fatty Acids. II. Synthesis of cis- and trans-5-Octenoic Acids

  摘要：

  DOI：

  10.1021/jo50003a010

文献信息

• Regio- and Stereoselective Ring Opening of ω-Alkenyllactones Using Organocopper Reagents
  作者：Masatoshi Kawashima、Toshio Sato、Tamotsu Fujisawa

  DOI：10.1246/bcsj.61.3255

  日期：1988.9

  by the regio- and stereoselective ring opening of β, γ, and δ-lactones with unsaturated substituents at the ω-position using organocopper reagents such as halomagnesium diorganocuprates or Grignard reagents in the presence of copper(I) iodide. Both the organocopper reagents with primary, secondary, tertiary alkyl, and phenyl groups gave the corresponding carbon homologated alkenoic acids in good yields

  描述了通过 β、γ 和 δ-内酯的区域和立体选择性开环来制备 (E)-3-、(E)-4- 和 (E)-5- 烯酸的新合成方法在碘化铜 (I) 存在下，使用有机铜试剂如卤化二有机铜酸盐或格氏试剂在 ω 位去除不饱和取代基。具有伯、仲、叔烷基和苯基的有机铜试剂均以良好的产率得到相应的碳同系链烯酸。通过 ω-烯基内酯与二乙烯基-和二烯丙基铜酸盐的反应，也以良好的产率获得链二烯酸。利用β-异丙烯基-β-丙内酯的开环，很容易以良好的收率获得高萜类羧酸。
• Synthesis of β-silyl ketones via reaction of trimethylsilyllthium with unsaturated hydrazones. Application to the synthesis of brevicomin
  作者：Paul F. Hudrlik、Anne M. Hudrlik、Tilahun Yimenu、Morris A. Waugh、G. Nagendrappa

  DOI：10.1016/s0040-4020(01)86637-0

  日期：1988.1

  undergoes conjugate addition to dimethylhydrazones of α,β-unsaturated ketones. The resulting metalloenamine intermediates can be alkylated, and the resulting hydrazone products cleaved to give α-substituted-β-silyl ketones. These reactions, together with a silicon-directed Baeyer-Villiger reaction, have been applied to the synthesis of brevicomin.

  三甲基甲硅烷基锂与α，β-不饱和酮的二甲基hydr共轭加成。可以将所得的金属烯胺中间体烷基化，并将所得的products产物裂解，得到α-取代的-β-甲硅烷基酮。这些反应，以及硅定向的Baeyer-Villiger反应，已被用于合成brevicomin。
• Process for producing hydroxylactones
  申请人：——

  公开号：US20040024228A1

  公开（公告）日：2004-02-05

  A process of the present invention produces a hydroxylactone by subjecting an unsaturated carboxylic acid having a double bond not conjugated to a carboxyl group or an ester thereof to (i) a reaction with hydrogen peroxide in the presence of a metallic compound containing a metallic element selected from W, Mo, V and Mn or (ii) a reaction with a peroxide containing the metallic element to thereby yield a corresponding hydroxylactone having a hydroxyl group combined with one of carbon atoms constituting the double bond and being cyclized at the other carbon atom position. The metallic compound may be one selected from oxides, oxoacids and salts thereof. The unsaturated carboxylic acid includes, for example, &bgr;,&ggr;-unsaturated carboxylic acids, &ggr;,&dgr;-unsaturated carboxylic acids, and &dgr;,&egr;-unsaturated carboxylic acids. The process can produce hydroxylactones in high yields at low cost.

  本发明的过程通过将具有未与羧基共轭的双键的不饱和羧酸或其酯与(i)含有W、Mo、V和Mn中选择的金属元素的金属化合物存在下的过氧化氢反应或(ii)与含有金属元素的过氧化物反应，从而得到具有羟基与构成双键的碳原子之一结合并在另一个碳原子位置环化的相应羟基内酯。金属化合物可以是从氧化物、氧酸和盐中选择的一种。不饱和羧酸包括例如β,γ-不饱和羧酸、γ,δ-不饱和羧酸和δ,ε-不饱和羧酸。该过程可以以低成本高产率生产羟基内酯。
• Pyrrolidin-2-One Derivatives for Use as Dp1 Receptor Agonists
  申请人：Araldi Luca Gian

  公开号：US20080027126A1

  公开（公告）日：2008-01-31

  The present invention is directed to compounds that may be used as agonists of prostaglandin receptors. More specifically, the specification describes methods and compositions for making and using DP1 receptor agonists that are pyrrolidin-2-one derivatives.

  本发明涉及可用作前列腺素受体激动剂的化合物。更具体地，本说明书描述了制备和使用吡咯烷-2-酮衍生物的DP1受体激动剂的方法和组合物。
• Organic Compounds and Compositions Having the Ability to Modulate Fragrance Compositions
  申请人：Schilling Boris

  公开号：US20100111888A1

  公开（公告）日：2010-05-06

  Disclosed are compounds having the ability to modulate, namely to improve, enhance and or modify fragrance compositions due to their ability to inhibit cytochrome P450 enzymes, e.g. CYP2A13 and CYP2B6.

  本发明涉及一种化合物，其具有调节香气组合物的能力，即由于其抑制细胞色素P450酶，例如CYP2A13和CYP2B6的能力，能够改善、增强和/或修改香气组合物。