2-{[(2-甲基-2-丙基)氧基]羰基}肼羧酸 | 256640-13-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-{[(2-甲基-2-丙基)氧基]羰基}肼羧酸
• 英文名称: Boc-carbazate
• 英文别名: 2-(tert-Butoxycarbonyl)hydrazine-1-carboxylic acid；[(2-methylpropan-2-yl)oxycarbonylamino]carbamic acid
• CAS: 256640-13-8
• 化学式: C₆H₁₂N₂O₄
• 分子量: 176.172
• InChiKey: ARTBCTJQNQUNSB-UHFFFAOYSA-N

物化性质

• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-{[(2-甲基-2-丙基)氧基]羰基}肼羧酸 、 4-碘-2-甲氧基苯甲酸甲酯 在 copper(l) iodide 、 1,10-菲罗啉 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以73.4%的产率得到tert-butyl 1-(3-methoxy-4-(methoxycarbonyl)phenyl)hydrazinecarboxylate
  参考文献：
  名称：

  WO2008/99145

  摘要：

  公开号：

文献信息

• POLY(OLIGOETHYLENE GLYCOL METHACRYLATE) HYDROGEL COMPOSITIONS, AND METHODS OF USE THEREOF
  申请人：McMaster University

  公开号：US20160151535A1

  公开（公告）日：2016-06-02

  The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

  本申请涉及包含第一和第二前体聚合物的水凝胶组合物，其中前体聚合物是经过电愿-亲核反应交联的改性聚(寡乙二醇甲基丙烯酸酯)共聚物。
• [EN] A PHOTOLABILE LINKER FOR THE SOLID-PHASE SYNTHESIS OF HYDRAZIDES AND PYRANOPYRAZOLES<br/>[FR] LIEUR PHOTOLABILE POUR LA SYNTHÈSE EN PHASE SOLIDE D'HYDRAZIDES ET DE PYRANOPYRAZOLES
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2015036481A1

  公开（公告）日：2015-03-19

  The photolabile hydrazine linker of the present invention is based on the o-nitro-veratryl group, which is capable of releasing hydrazide derivatives upon UV irradiation. The linker allows for a new solid-phase peptide synthesis (SPPS) strategy which is fully orthogonal to the most commonly used protecting groups and chemical methods in SPPS and shows excellent compatibility with peptide composition, notably the 20 naturally occurring α-amino acid residues (even in their side-chain protected form) are accepted in the C-terminal of the peptide hydrazides. Furthermore, the linker unit can be applied to synthesize combinatorial libraries of biological interesting heterocyclic compounds, such as pyranopyrazoles.

  本发明的光敏式肼连接剂基于邻硝基维拉特基团，能够在紫外辐射下释放肼衍生物。该连接剂允许一种全新的固相肽合成（SPPS）策略，与SPPS中最常用的保护基和化学方法完全正交，并且与肽组成非常兼容，特别是在肽肼酰的C末端接受20种天然存在的α-氨基酸残基（即使是它们的侧链保护形式）。此外，该连接单元可用于合成生物感兴趣的杂环化合物的组合式库，如吡喃吡唑。
• Novel compounds and therapeutic uses thereof
  申请人：TORRENT PHARMACEUTICALS LTD.

  公开号：US20040106802A1

  公开（公告）日：2004-06-03

  The invention discloses a novel series of compound represented by general formula (I), 1 its derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, solvates wherein X, n, k, z, R1, R2, R3, R4, R5 and R6 are as defined in the specification that are useful in (i) normalizing elevated blood glucose levels in diabetes, (ii) treating disorders related to glucose intolerance and (iii) for scavenging free radicals of mammals. The invention also discloses pharmaceutically acceptable composition comprising these compounds, method for preparation of the compounds as defined above and method of treating mamnnals including human beings by administering an effective amount of said compounds to a subject in need thereof. The invention further discloses use of these compounds in the manufacture of a medicament useful for treatment of different disease conditions as stated above.

  该发明揭示了一种由通式(I)表示的新型化合物系列，其衍生物、类似物、互变异构体、立体异构体、多型体、药用可接受盐、溶剂合物，其中X、n、k、z、R1、R2、R3、R4、R5和R6如规范中定义的那样，在(i)正常化糖尿病患者的升高血糖水平，(ii)治疗与葡萄糖不耐受有关的疾病，以及(iii)清除哺乳动物体内自由基方面具有用处。该发明还揭示了包括这些化合物的药用可接受组合物，所述化合物的制备方法如上所述，并通过向需要的受试者施用有效量的该化合物来治疗包括人类在内的哺乳动物的方法。该发明进一步揭示了这些化合物在制造用于治疗上述不同疾病状况的药物中的应用。
• Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20050209197A1

  公开（公告）日：2005-09-22

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有抗HIV蛋白酶活性的膦酸酯取代化合物，可用作治疗剂和其他工业用途。该组合物抑制HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面有用，以及在检测HIV蛋白酶的测定中有用。
• Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20070010489A1

  公开（公告）日：2007-01-11

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有HIV蛋白酶抑制剂性质的膦酸酯取代化合物，其具有作为治疗剂和其他工业用途的用途。该组合物抑制5型HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面具有治疗作用，以及在检测HIV蛋白酶方面的检测中有用。