p-Hydroxy-benzylfluorid | 62037-85-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Hydroxy-benzylfluorid
• 英文别名: 4-(Fluoromethyl)phenol
• CAS: 62037-85-8
• 化学式: C₇H₇FO
• 分子量: 126.13
• InChiKey: HTYDXVJLNUOSGR-UHFFFAOYSA-N

物化性质

• 沸点：
  222.4±15.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-氯丙基)哌啶 、 p-Hydroxy-benzylfluorid 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 48.0h， 生成 1-(3-(4-(Fluoromethyl)phenoxy)propyl)piperidine
  参考文献：
  名称：

  Fluorinated non-imidazole histamine H3 receptor antagonists

  摘要：

  Fluorine substituents have become a widespread and important component in drug design and development. Here, the synthesis of fluorine containing compounds and some corresponding precursor molecules are presented for potential isotope labelling as well as their data obtained with in vitro and in vivo screenings. The compounds vary in the basic centres (piperidine or pyrrolidine) and are fluoro substituted in different positions of the basic alicyclic moiety. Pharmacological evaluation resulted in ligands with high affinities at hH(3) receptor in the nanomolar and subnanomolar concentration range and some with high antagonist in vivo potencies. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.110
• 作为产物：
  描述：

  对羟基苯甲醇 在 potassium fluoride 、 三苯基膦 作用下， 以 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以92%的产率得到p-Hydroxy-benzylfluorid
  参考文献：
  名称：

  Practical and General Method for Direct Synthesis of Alkyl Fluorides from Alcohols under Mild Conditions

  摘要：

  A variety of alcohols were treated with Ph3P and KF in CCl4-DMF at room temperature to afford the corresponding fluorides in very good yields.

  DOI：

  10.1007/s00706-005-0296-9

文献信息

• Separation of amine from a phenolic compound
  申请人：Renner A. Carl

  公开号：US20050080294A1

  公开（公告）日：2005-04-14

  A process comprises contacting a product mixture with a base, optionally in the presence of a polyhydric alcohol, to produce a base-treated mixture and distilling the base-treated mixture in which the product mixture comprises an aromatic amine and a phenolic compound.

  一个过程包括将产品混合物与碱接触，可选地在多元醇的存在下，以产生经碱处理的混合物，并蒸馏经碱处理的混合物，其中产品混合物包括芳香胺和酚化合物。
• Method for producing an olefin type copolymer having a cyclic structure
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20020058767A1

  公开（公告）日：2002-05-16

  A method for producing an olefin type copolymer having a cyclic structure, which comprises copolymerizing ethylene (M1) and dicyclopentadiene or tricyclopentadiene (M2), and, as optionally introduced, a cyclic olefin (M3), wherein, as a catalyst, a catalyst comprising a metallocene compound (A) of the following formula [1]: H 2 C(R′ m CP)(R″ n Cp)Mx 2 [1] wherein M is zirconium or hafnium, Cp is a group having a cyclopentadienyl skeleton, each of R′ and R″ is a hydrocarbon group having 1 to 10 carbon atoms, each of two X's which may be the same or different from each other, is a halogen atom, a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms, a halogenated hydrocarbon group, an alkylamino group, an alkoxy group, an aryloxy group of the formula —O—Ar—Y p (wherein Ar is an aromatic ring, Y is a halogen atom, a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms, a halogenated hydrocarbon group, an alkoxy group, an alkylamino group, a cyano group or a nitro group, and p is an integer of from 1 to 5), a thioalkyl group, or a thioaryl group of the formula —S—Ar—Y p (wherein Ar, Y and p are as defined above), and each of m and n is an integer of from 0 to 4, provided that m and n are not equal, and m+n is an integer of from 3 to 6, and an aluminoxane (B), is used.

  一种制备具有环状结构的烯烃共聚物的方法，包括共聚乙烯（M1）和二环戊二烯或三环戊二烯（M2），以及作为可选引入的环状烯烃（M3），其中，作为催化剂使用以下式子（1）的金属茂化合物（A）：H2C(R′mCP)(R″nCp)Mx2（1），其中M为锆或铪，Cp为具有环戊二烯基骨架的基团，R′和R″各自为具有1至10个碳原子的碳氢基团，两个X可以相同也可以不同，是卤素原子、氢原子、具有1至20个碳原子的碳氢基团、卤代碳氢基团、烷基氨基基团、烷氧基、苯氧基（式中Ar为芳香环，Y为卤素原子、氢原子、具有1至20个碳原子的碳氢基团、卤代碳氢基团、烷氧基、烷基氨基基团、氰基或硝基，p为1至5的整数），硫代烷基团或硫代芳基团（式中Ar、Y和p如上所述），m和n各自为0至4的整数，但m和n不相等，且m+n为3至6的整数，并使用铝烷氧化物（B）。
• CHIRAL IRIDIUM AQUA COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE HYDROXY COMPOUND USING THE SAME
  申请人：Carreira Erick M.

  公开号：US20110137049A1

  公开（公告）日：2011-06-09

  The invention provides a chiral iridium aqua complex which has good preservation stability, can be easily produced, and enables asymmetric transfer hydrogenation in a higher yield and with higher stereoselectivity. The chiral iridium aqua complex has the formula (1A): wherein R a , R b , R c , R d and R e are the same or different and each is a hydrogen atom, a methyl group, an ethyl group or a phenyl group, R 1 and R 2 are the same or different and each is an aryl group optionally having substituent(s), or R 1 and R 2 in combination show a C 3-4 straight chain alkylene group optionally having substituent(s) to form a ring, R 3 is an alkylsulfonyl group optionally having substituent(s) or an arylsulfonyl group optionally having substituent(s), R 4 is a hydrogen atom, an alkylsulfonyl group optionally having substituent(s) or an arylsulfonyl group optionally having substituent(s), X is a monovalent or divalent anion, and n is 2 when X is a monovalent anion, or n is 1 when X is a divalent anion, and a production method of an optically active hydroxy compound using the complex.

  本发明提供了一种手性的铱水合物配合物，具有良好的保持稳定性，易于生产，并且能够在更高的产率和立体选择性下进行不对称转移氢化反应。该手性铱水合物配合物的化学式为（1A）：其中，Ra、Rb、Rc、Rd和Re是相同或不同的氢原子、甲基基团、乙基基团或苯基基团；R1和R2是相同或不同的芳基基团，可选地具有取代基，或者R1和R2组合形成一个C3-4直链烷基链，可选地具有取代基，形成一个环；R3是一个烷基磺酰基，可选地具有取代基，或者是一个芳基磺酰基，可选地具有取代基；R4是一个氢原子，一个烷基磺酰基，可选地具有取代基，或者是一个芳基磺酰基，可选地具有取代基；X是一价或二价的阴离子；当X是一价阴离子时，n为2；当X是二价阴离子时，n为1。本发明还提供了使用该配合物制备光学活性羟基化合物的方法。
• Verwendung von Fluormethylphenolen als Lösungsmittel für LC-Polymere, und neue Fluormethylphenole
  申请人：BAYER AG

  公开号：EP0286953A1

  公开（公告）日：1988-10-19

  Bestimmte Fluormethylphenole, wie z.B. 3,5-Bis-tri­fluormethylphenol, sind geeignete Lösungsmittel für LC-Polymere. Mit Hilfe dieser Verbindungen können viele LC-Polymere, die bislang als in organischen Lösungsmit­teln unlöslich galten, in Lösung gebracht werden. Sie werden dadurch besser analysierbar und lassen sich aus Lösung verarbeiten.

  某些氟甲基苯酚，如 3,5-双三氟甲基苯酚，是液相色谱聚合物的合适溶剂。在这些化合物的帮助下，许多以前被认为不溶于有机溶剂的液相色谱聚合物可以进入溶液。这使得它们更易于分析，并可从溶液中进行处理。
• Copolymerization of dicyclopentadiene with norbornene derivatives and copolymers obtainable therewith
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0372600A2

  公开（公告）日：1990-06-13

  A process for the production of thermoset copolymers, having tailored product properties and more particularly a predetermined increase of the glass-­transition temperature and/or increase of cross-­linking, comprising contacting the comonomer mixture with a methathesis catalyst system, obtainable by combining at least a catalyst component and an activator component, characterized in that the comonomer one or more compounds are used, according to the formulae: Comonomers to be used for said process and reaction mixtures or components thereof containing such comonomers; and thermoset copolymers obtained by said process.

  一种用于生产热固性共聚物的工艺，该工艺具有定制的产品特性，特别是预定的玻璃化转变温度的提高和/或交联度的提高，包括将共聚单体混合物与甲烷化催化剂体系接触，该催化剂体系可由至少一种催化剂组分和一种活化剂组分组合而成，其特征在于共聚单体中使用了一种或多种化合物，其配方如下： 用于所述工艺的共聚单体和含有此类共聚单体的反应混合物或其组分；以及通过所述工艺获得的热固性共聚物。