2-丁基吗啉 | 90226-70-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 2-丁基吗啉
• 英文名称: 2-Butylmorpholine
• CAS: 90226-70-3
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: KEJDUUFWAWCFEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-6-(3-fluoropyridin-4-yl)-3-methylpyrimidin-4(3H)-one 、 2-丁基吗啉 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 2-(2-Butylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-3-methylpyrimidin-4-one
  参考文献：
  名称：

  Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer’s disease

  摘要：

  We herein describe the results of further evolution of GSK-3 beta inhibitors for Alzheimer's disease from our promising compounds with in vivo tau phosphorylation inhibitory activity by oral administration. Introduction of a low alkyl group instead of the phenyl group at the 3-position of the morpholine moiety aiming to improve pharmacokinetic profiles resulted in potent low molecular weight GSK-3 beta inhibitors with good in vitro pharmacokinetic profiles, which also showed in vivo tau phosphorylation inhibitory activity by oral administration. Effect of the stereochemistry of the alkyl moiety is also discussed using docking models. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.01.005
• 作为产物：
  描述：

  1-Bromo-2-(2-bromo-ethoxy)-hexane 、 氨 、 苯 以64%的产率得到
  参考文献：
  名称：

  GURBANOV P. A.; AZIZOV A. M.; MOVSUMZADE M. M.; XODZHAEV G. X., DOKL. AN AZSSR, 42,(1986) N 4, 24-28

  摘要：

  DOI：

文献信息

• [EN] CATALYTIC PREPARATION OF SEVERELY STERICALLY HINDERED AMINO-ETHER ALCOHOLS USING A METAL LOADED CATALYST<br/>[FR] PREPARATION CATALYTIQUE D'ALCOOLS AMINO-ETHER A ENCOMBREMENT STERIQUE SEVERE UTILISANT UN CATALYSEUR A CHARGE METALLIQUE
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2005082834A1

  公开（公告）日：2005-09-09

  The present invention relates to a process for the production of severely sterically hindered amino-ether alcohols using a catalyst based on the combination of one or more catalytically active metals supported in a dispersed form on one or more ordered mesoporous materials as support.

  本发明涉及一种利用基于一个或多个催化活性金属的组合在一个或多个有序介孔材料上以分散形式支撑的催化剂的过程，用于生产严重立体位阻的氨基醚醇。
• [EN] SMALL MOLECULE FATTY ACID SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS DE SYNTHASE D'ACIDES GRAS À PETITES MOLÉCULES
  申请人：SANFORD BURNHAM MED RES INST

  公开号：WO2015134790A1

  公开（公告）日：2015-09-11

  Provided herein are small molecule Fatty Acid Synthase Inhibitors, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

  本文提供了小分子脂肪酸合成酶抑制剂，包括这些化合物的组合物，以及使用这些化合物和包括这些化合物的组合物的方法。
• METHOD FOR SEPARATING AROMATIC COMPOUNDS CONTAINED IN NAPHTHA
  申请人：LOTTE CHEMICAL CORPORATION

  公开号：US20160075952A1

  公开（公告）日：2016-03-17

  The present invention relates to a method for separating aromatic compounds contained in naphtha which includes an extraction step of contacting specific ionic liquids and naphtha and a step of separating the aromatic compounds from naphtha contacted with the ionic liquids.

  本发明涉及一种分离萘油中含有的芳香化合物的方法，包括将特定离子液体与萘油接触的萃取步骤和从与离子液体接触的萘油中分离芳香化合物的步骤。
• BIS tertiary amino alkyl derivatives as solvents for acid gas removal from gas streams
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0124835A2

  公开（公告）日：1984-11-14

  A process is set forth for the selective removal of acid gases such as H2S, COS and CO2from a gas stream by contacting the stream with a bis tertiary amino alkyl solvent compound such as bis-(2-morpholino ethyl) ether. When used in an aqueous solution, the compounds catalytically hydrolyze COS to H2S and CO2.

  本发明提出了一种选择性去除气流中 H2S、COS 和 CO2 等酸性气体的工艺，方法是将气流与双叔氨基烷基溶剂化合物（如双（2-吗啉基乙基）醚）接触。在水溶液中使用时，这些化合物可催化 COS 水解为 H2S 和 CO2。
• WATER-ABSORBENT RESIN DISPERSION AND POLYURETHANE COMPOSITION
  申请人：SANYO CHEMICAL INDUSTRIES, LTD.

  公开号：EP0789062A1

  公开（公告）日：1997-08-13

  A water-absorbent resin dispersion comprising a water-absorbent resin (B) or a hydrous gel thereof dispersed in a liquid or heat-meltable organic active-hydrogen compound (A), wherein said resin (B) is formed by the polymerization of a water-soluble monomer or its precursor and a cross-linker and/or a polysaccharide in the compound (A); and a process for producing a polyurethane resin by the reaction of the dispersion with an organic polyisocyanate compound. As the polyurethane resin is excellent in the capacity and rate of absorption, it is useful as absorbent articles such as paper diaper and sanitary goods, humidity modifiers, cutoff material, and so forth.

  一种吸水性树脂分散体，包括分散在液态或可加热熔化的有机活性氢化合物（A）中的吸水性树脂（B）或其水凝胶，其中所述树脂（B）由化合物（A）中的水溶性单体或其前体与交联剂和/或多糖聚合而成；以及一种通过分散体与有机多异氰酸酯化合物反应生产聚氨酯树脂的工艺。由于聚氨酯树脂的吸水能力和吸水速度极佳，因此可用作纸尿布和卫生用品等吸水物品、湿度调节剂、切断材料等。