环丙基2-氟苯基乙炔 | 1391053-47-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 环丙基2-氟苯基乙炔
• 英文名称: Cyclopropyl 2-Fluorophenylacetylene
• 英文别名: 1-(2-cyclopropylethynyl)-2-fluorobenzene
• CAS: 1391053-47-6
• 化学式: C₁₁H₉F
• 分子量: 160.191
• InChiKey: SOQKPJODEXGRGG-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于氯仿、可溶于二氯甲烷、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  环丙基2-氟苯基乙炔 、 对甲苯磺酰胺 在 silver hexafluoroantimonate 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以77%的产率得到
  参考文献：
  名称：

  Ru(II)-catalyzed ring expansion of alkynylcyclopropanes in the presence of sulfonamides

  摘要：

  Ru(II)-catalyzed ring expansion of alkynylcyclopropanes to alkylidenecyclobutanamines using a variety of cyclopropane and sulfonamide substrates was developed and shown to give moderate to excellent yields. (C) 2013, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s1872-2067(12)60680-9

文献信息

• Asymmetric α-Pentadienylation of Aldehydes with Cyclopropylacetylenes
  作者：Min-Song Wu、Zhi-Yong Han、Liu-Zhu Gong

  DOI：10.1021/acs.orglett.0c03466

  日期：2021.2.5

  cyclopropylacetylene and its derivatives as the pentadienylation reagent, an asymmetric regioselective asymmetric α-pentadienylation reaction of aldehydes is developed by cooperative catalysis of a chiral Pd(0) catalyst and a chiral Brønsted acid in the presence of a subschoichmetric amount of an achiral amine. α-Pentadienylated aldehydes are afforded with high yields and enantioselectivities as well as excellent

  通过使用现成的环丙基乙炔及其衍生物作为戊二烯基化试剂，通过亚催化量的手性Pd（0）催化剂和手性布朗斯台德酸的协同催化，开发了醛类的不对称区域选择性不对称α-戊二烯基化反应。非手性胺。以高收率和对映选择性以及出色的E / Z比提供α-戊二烯基化醛。
• Palladium-Catalyzed Allylation of Cyclopropyl Acetylenes with Oxindoles to Construct 1,3-Dienes
  作者：Chuan-Jun Lu、Xin Yu、Yu-Ting Chen、Qing-Bao Song、Zhen-Ping Yang、Hong Wang

  DOI：10.1002/ejoc.201901536

  日期：2020.2.14

  A novel palladium‐catalyzed allylic alkylation of oxindoles with cyclopropyl acetylenes has been developed. Various 1,3‐diene oxindole framework bearing a quaternary stereocenter at the C3 position were synthesized straightforwardly in good to excellent yields with high regio‐, and stereoselectivities.

  已经开发了一种新型的钯催化的吲哚与环丙基乙炔的烯丙基烷基化反应。在C3位置带有一个四级立体中心的各种1,3-二烯氧吲哚骨架可以直接合成，具有良好的产率和优异的选择性，并具有较高的区域选择性和立体选择性。
• Ru(II)-catalyzed ring expansion of alkynylcyclopropanes in the presence of sulfonamides
  作者：Yuye Chen、Junsong Wang、Xingwei Li、Aiqun Jia

  DOI：10.1016/s1872-2067(12)60680-9

  日期：2013.10

  Ru(II)-catalyzed ring expansion of alkynylcyclopropanes to alkylidenecyclobutanamines using a variety of cyclopropane and sulfonamide substrates was developed and shown to give moderate to excellent yields. (C) 2013, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.