3-amino-4-methyl-benzophenone | 62261-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-4-methyl-benzophenone
• 英文别名: 3-Amino-4-methyl-benzophenon；(3-amino-4-methylphenyl)phenyl-methanone；3-Amino-4-methylbenzophenone；(3-amino-4-methylphenyl)-phenylmethanone
• CAS: 62261-44-3
• 化学式: C₁₄H₁₃NO
• 分子量: 211.263
• InChiKey: HCFKCCTUUVWZFT-UHFFFAOYSA-N

物化性质

• 熔点：
  107.5 °C
• 沸点：
  406.5±33.0 °C(Predicted)
• 密度：
  1.135±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-amino-4-methyl-benzophenone 在 盐酸 、 五氯化磷 、 硫酸 、 硝酸 、 sodium nitrite 、 苯 作用下， 生成 2,4-dibenzoyl-benzoic acid
  参考文献：
  名称：

  Chardonnens; Schlapbach, Helvetica Chimica Acta, 1946, vol. 29, p. 1413,1417

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基二苯甲酮 在 硝酸 、 铁粉 、 溶剂黄146 作用下， 生成 3-amino-4-methyl-benzophenone
  参考文献：
  名称：

  Chardonnens, Helvetica Chimica Acta, 1929, vol. 12, p. 659

  摘要：

  DOI：

文献信息

• Anthranilic acid derivative or salt thereof
  申请人：Toyama Chemical Co., Ltd.

  公开号：US07999132B2

  公开（公告）日：2011-08-16

  An anthranilic acid derivative represented by the general formula (X) [wherein R1 represents hydrogen or a carboxy-protecting group; R2 represents optionally substituted phenyl, a heterocyclic group, etc.; R3 represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X1 represents carbonyl, etc.; X2 represents optionally substituted alkylene group, a bond, etc.; X3 represents oxygen, a bond, etc.; and X4 represents a group represented by the general formula —X5—X6— or —X6—X5— (wherein X5 means oxygen, a bond, etc.; and X6 means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.

  一种由通式（X）表示的蒽酸衍生物[其中R1表示氢原子或羧基保护基；R2表示可选取代的苯基，杂环基等；R3表示可选取代的苯基，单环杂环基等；X1表示羰基等；X2表示可选取代的烷基，键等；X3表示氧原子，键等；X4表示由通式-X5-X6-或-X6-X5-表示的基团（其中X5表示氧原子，键等；X6表示可选取代的烷基，键等）]或其盐。该衍生物或盐具有MMP-13生产的抑制活性，因此可用作治疗关节风湿病、骨关节炎、癌症等的治疗剂。
• Method for hydrogel surface treatment and article formed therefrom
  申请人：——

  公开号：US20010024697A1

  公开（公告）日：2001-09-27

  A method of modifying the surface characteristics of a polymeric hydrogel, and a polymer article formed therefrom, without causing substantial swelling or distortion or the hydrogel. A preferred method includes photoinitating of the surface of the article with a benzophenone and grafting a macromer having a number-average molecular weight greater than 1000 in the presence of UV irradiation. The preferred article is a siloxane-containing hydrogel, especially a soft contact lens.

  一种改变聚合物水凝胶及其形成的聚合物制品表面特性的方法，而不会导致水凝胶严重膨胀或变形。一种优选的方法包括用二苯甲酮光敏制品表面，并在紫外线照射下接枝一种平均分子量大于 1000 的大分子。优选的物品是含硅氧烷的水凝胶，尤其是软性隐形眼镜。
• EP1820795
  申请人：——

  公开号：——

  公开（公告）日：——
• Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides
  作者：John J. Parlow、Deborah A. Mischke、Scott S. Woodard

  DOI：10.1021/jo970571i

  日期：1997.8.1

  The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.
• NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1860098B1

  公开（公告）日：2012-11-14