3-(3-pyridyl)-1-propyl (2S)-1-[(1',1'-dimethylpropyl)carbamoyl]-pyrrolidine-2-carboxylate | 212607-80-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(3-pyridyl)-1-propyl (2S)-1-[(1',1'-dimethylpropyl)carbamoyl]-pyrrolidine-2-carboxylate
• 英文别名: 3-(3-Pyridyl)-1-propyl (2S)-1-[(1',1'-dimethylpropyl)carbamoyl]pyrrolidine-2-carboxylate；3-(3-Pyridyl)-1-propyl 2S-1-[(1',1'-Dimethylpropyl)carbamoyl]-pyrrolidine-2-carboxylate；3-(3-Pyridyl)-1-propyl 2S-1-[(1',1'-Dimethylpropyl)carbamoyl]pyrrolidine-2-carboxylate；3-pyridin-3-ylpropyl (2S)-1-(2-methylbutan-2-ylcarbamoyl)pyrrolidine-2-carboxylate
• CAS: 212607-80-2
• 化学式: C₁₉H₂₉N₃O₃
• 分子量: 347.458
• InChiKey: IZZNKAHHWWUOJV-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  叔戊基胺 、 三光气 、 3-(3-pyridyl)-1-propyl (2S)-pyrrolidine-2-carboxylate 生成 3-(3-pyridyl)-1-propyl (2S)-1-[(1',1'-dimethylpropyl)carbamoyl]-pyrrolidine-2-carboxylate
  参考文献：
  名称：

  Carbamate and urea compositions and neurotrophic uses

  摘要：

  这项发明涉及使用对FKBP型免疫蛋白亲和力的低分子量、小分子量的碳酸酯和脲类化合物来影响神经元活动的制药组合物和方法。

  公开号：

  US06242468B1

文献信息

• Pyrrolidine derivative hair growth compositions and uses
  申请人：GPL NIL Holdings, Inc.,

  公开号：US20010049381A1

  公开（公告）日：2001-12-06

  This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.

  这项发明涉及使用吡咯烷衍生物治疗脱发并促进头发生长的药物组合物和方法。
• N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
  申请人：GPI NIL Holdings, Inc.

  公开号：US20020065297A1

  公开（公告）日：2002-05-30

  This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.

  这项发明涉及使用杂环酯、酰胺、硫酯或酮的N-氧化物治疗脱发和促进头发生长的药物组合物和方法。
• Small molecule carbamates or ureas for vision and memory disorders
  申请人：GPI Nil Holdings, Inc.

  公开号：US06395758B1

  公开（公告）日：2002-05-28

  This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using small molecule carbamates and ureas.

  这项发明涉及使用小分子碳酸酯和脲类化合物治疗视觉障碍、改善视力、治疗记忆障碍或增强记忆表现的药物组合物和方法。
• Method for treating nerve injury caused as a result of surgery
  申请人：——

  公开号：US20030203890A1

  公开（公告）日：2003-10-30

  The present invention relates generally to methods for treating or preventing nerve injury in a warm-blooded animal caused as a consequence of surgery by administering neurotrophic compounds described below. The invention relates more specifically to methods for treating or preventing nerve injury caused as a consequence of prostate surgery as well as erectile dysfunction.

  本发明一般涉及通过给予下文描述的神经营养化合物来治疗或预防温血动物因手术而引起的神经损伤的方法。该发明更具体地涉及治疗或预防由前列腺手术以及勃起功能障碍引起的神经损伤的方法。
• Small molecule carbamate or urea hair growth compositions and uses
  申请人：GPI NIL Holdings, Inc.

  公开号：US06194440B1

  公开（公告）日：2001-02-27

  This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using small molecule carbamates and ureas.

  这项发明涉及使用小分子羰胺和脲类化合物治疗脱发和促进头发生长的药物组合物和方法。