DTPA-PE | 217327-40-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DTPA-PE
• 英文别名: (10s,13r)-3-{2-[{2-[bis(Carboxymethyl)amino]ethyl}(Carboxymethyl)amino]ethyl}-10-Hydroxy-5,16-Dioxo-13-(Tetradecanoyloxy)-9,11,15-Trioxa-3,6-Diaza-10-Phosphanonacosan-1-Oic Acid 10-Oxide；2-[2-[bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[2-[[(2R)-2,3-di(tetradecanoyloxy)propoxy]-hydroxyphosphoryl]oxyethylamino]-2-oxoethyl]amino]ethyl]amino]acetic acid
• CAS: 217327-40-7
• 化学式: C₄₇H₈₇N₄O₁₇P
• 分子量: 1011.2
• InChiKey: DAAFWSGIXJNAQE-RRHRGVEJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  69
• 可旋转键数：
  52
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  296
• 氢给体数：
  6
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  二亚乙基三胺五乙酸二酐 、 1,2-十四酰基磷脂酰乙醇胺 生成 DTPA-PE
  参考文献：
  名称：

  [EN] METHODS AND COMPOSITIONS FOR IMAGING
  [FR] PROCEDES ET COMPOSITIONS CONÇUS POUR L'IMAGERIE

  摘要：

  本发明涉及一种用于MRI、CT、伽马闪烁或光学成像技术中的成像剂的组合物。描述了使用相同的方法和组合物。

  公开号：

  WO2005070400A1

文献信息

• Nano-liposome carrier composition containing hybrid of Cas9 protein and guide RNA
  申请人：Moogene Medi Co. Ltd.

  公开号：US10363217B2

  公开（公告）日：2019-07-30

  The present invention relates to nano-liposome carrier compositions that encapsulate a hybrid of a Cas9 protein and a guide RNA and methods of making and using the same. The nano-liposome carrier compositions have an excellent effect of suppressing expression of target DNA, and thus pharmaceutical compositions including the nano-liposome carrier compositions can be used for treating diseases such as diabetes.

  本发明涉及封装Cas9蛋白和引导RNA杂交体的纳米脂质体载体组合物及其制造和使用方法。该纳米脂质体载体组合物具有抑制靶 DNA 表达的良好效果，因此包括该纳米脂质体载体组合物的药物组合物可用于治疗糖尿病等疾病。
• NANO-LIPOSOME CARRIER COMPOSITION CONTAINING HYBRID OF Cas9 PROTEIN AND GUIDE RNA
  申请人：Moogene Medi Co. Ltd.

  公开号：US20180193269A1

  公开（公告）日：2018-07-12

  The present invention relates to nano-liposome carrier compositions that encapsulate a hybrid of a Cas9 protein and a guide RNA and methods of making and using the same. The nano-liposome carrier compositions have an excellent effect of suppressing expression of target DNA, and thus pharmaceutical compositions including the nano-liposome carrier compositions can be used for treating diseases such as diabetes.
• NANOLIPOSOME-MICROBUBBLE CONJUGATE HAVING COMPLEX OF CAS9 PROTEIN, GUIDE RNA INHIBITING SRD5A2 GENE EXPRESSION AND CATIONIC POLYMER ENCAPSULATED IN NANOLIPOSOME AND COMPOSITION FOR AMELIORATING OR TREATING HAIR LOSS CONTAINING THE SAME
  申请人：MOOGENE MEDI CO., LTD

  公开号：US20210369859A1

  公开（公告）日：2021-12-02

  The present invention relates to a nanoliposome-microbubble conjugate, in which a complex of a Cas9 protein, a guide RNA inhibiting SRD5A2 gene expression and a cationic polymer is encapsulated in a nanoliposome, and to a composition for the amelioration or treatment of hair loss containing the same. Currently, drugs used for the treatment of hair loss cause serious side effects such as loss of libido or erectile dysfunction, and hair loss progresses again when drug treatment is stopped. However, when the nanoliposome-microbubble conjugate of the present invention is used, the expression of SRD5A2 inducing hair loss can be fundamentally suppressed, and the treatment of male hair loss can be performed very effectively.
• [EN] METHODS AND COMPOSITIONS FOR IMAGING<br/>[FR] PROCEDES ET COMPOSITIONS CONÇUS POUR L'IMAGERIE
  申请人：SINAI SCHOOL MEDICINE

  公开号：WO2005070400A1

  公开（公告）日：2005-08-04

  The present invention is directed to compositions useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. Methods and compositions of using the same are described.

  本发明涉及一种用于MRI、CT、伽马闪烁或光学成像技术中的成像剂的组合物。描述了使用相同的方法和组合物。