2,2,3,4-tetramethyl-glutaric acid | 90647-61-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,3,4-tetramethyl-glutaric acid
• 英文别名: 2,2,3,4-Tetramethyl-glutarsaeure；α,α,α',β-Tetramethyl-glutarsaeure；2,2,3,4-Tetramethylpentanedioic acid；2,2,3,4-tetramethylpentanedioic acid
• CAS: 90647-61-3
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: RFMRXDQNNXPYKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2-二甲基-3-氧代丁酸乙酯 在 五氯化磷 、 溶剂黄146 、 铂 、 锌 、 苯 作用下， 生成 2,2,3,4-tetramethyl-glutaric acid
  参考文献：
  名称：

  Baker, Journal of the Chemical Society, 1931, p. 1552

  摘要：

  DOI：

文献信息

• Separation of diastereoisomers
  申请人：Morini Giampiero

  公开号：US20050171379A1

  公开（公告）日：2005-08-04

  Process for modifying the relative ratios of the components of a liquid starting mixture of specific diastereoisomers, containing at least two asymmetric carbon atoms comprising contacting said liquid mixture with a Lewis acid compound capable of co-ordinating said specific diastereoisomers and subjecting the resulting mixture to conditions such that a reaction product, having a molar ratio between its diastereoisomeric components different from the corresponding molar ratio in the said liquid starting mixture, becomes separated from the said liquid mixture, said process being carried out using an amount of said Lewis acid not enough to co-ordinate the total amount of the diastereoisomeric components of the liquid starting mixture. This method shows an excellent balance of efficiency and easiness of procedure that cannot be reached with the physical methods of diastereoisomers separation known in the art.

  改变含有至少两个不对称碳原子的特定非对映异构体的液体起始混合物的组分相对比例的工艺，包括将所述液体混合物与能够配位所述特定非对映异构体的路易斯酸化合物接触，并将所得混合物置于一定条件下，使反应产物从所述液体混合物中分离出来，该反应产物的非对映异构体组分摩尔比不同于所述液体起始混合物中的相应摩尔比、该反应产物的非对映异构体组分摩尔比不同于上述液体起始混合物中的相应摩尔比，该反应产物从上述液体混合物中分离出来，该过程中使用的路易斯酸的量不足以协调液体起始混合物中非对映异构体组分的总量。这种方法在效率和操作简便性之间取得了极佳的平衡，是本领域已知的非对映异构体分离物理方法所无法达到的。
• 576. Taxine. Part II. Glycol cleavage fragments from O-cinnamoyltaxicin-I
  作者：B. W. Langley、B. Lythgoe、B. Scales、R. M. Scrowston、S. Trippett、D. Wray

  DOI：10.1039/jr9620002972

  日期：——
• SEPARATION OF DIASTEREOISOMERS
  申请人：Basell Poliolefine Italia S.r.l.

  公开号：EP1458661B1

  公开（公告）日：2007-05-02
• US7067690B2
  申请人：——

  公开号：US7067690B2

  公开（公告）日：2006-06-27
• [EN] SEPARATION OF DIASTEREOISOMERS<br/>[FR] SEPARATION DE DIASTEREOISOMERES
  申请人：BASELL POLIOLEFINE SPA

  公开号：WO2003055831A1

  公开（公告）日：2003-07-10

  Process for modifying the relative ratios of the components of a liquid starting mixture of specific diastereoisomers, containing at least two asymmetric carbon atoms comprising contacting said liquid mixture with a Lewis acid compound capable of co-ordinating said specific diastereoisomers and subjecting the resulting mixture to conditions such that a reaction product, having a molar ratio between its diastereoisomeric components different from the corresponding molar ratio in the said liquid starting mixture, becomes separated from the said liquid mixture, said process being carried out using an amount of said Lewis acid not enough to co-ordinate the total amount of the diastereoisomeric components of the liquid starting mixture. This method shows an excellent balance of efficiency and easiness of procedure that cannot be reached with the physical methods of diastereoisomers separation known in the art.