2-Amino-4-methyl pent-3-en saeure | 498-29-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-4-methyl pent-3-en saeure
• 英文别名: 2-Amino-4-methylpent-3-enoic acid
• CAS: 498-29-3
• 化学式: C₆H₁₁NO₂
• mdl: MFCD17170927
• 分子量: 129.159
• InChiKey: KAHGFLCFAKHKOZ-UHFFFAOYSA-N

物化性质

• 沸点：
  265.0±28.0 °C(Predicted)
• 密度：
  1.079±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2E)-4-methylpent-2-enoic acid 在 N-溴代丁二酰亚胺(NBS) 、 氨 作用下， 以 四氯化碳 为溶剂， 生成 2-Amino-4-methyl pent-3-en saeure
  参考文献：
  名称：

  Synthesis of Analogues of GABA. II. 4-Alkyl-4-aminobut-2-enoic Acids and a New Synthesis of Some Vinyl α-Amino Acids

  摘要：

  一系列 制备了一系列 4-烷基-4-氨基丁-2-烯酸 (2)-(5) 作为 GABA 的构象受限类似物。 限制的 GABA 类似物。合成路线包括烯丙基溴化，然后用氨置换 乙烯基甘氨酸类似物(7)-(9)。 反应的副产品。乙烯基甘氨酸类似物 (E)-2-氨基环己基亚基乙酸（4）和(E)-2-氨基环己基亚基乙酸（5）对 GABA 吸收、结合和酶系统的体外生物活性较低。 和 (E)-2-aminocyclopentylideneacetic acid (5) 的体外生物活性较低，这是因为 在有关的特定活性位点上，成环亚甲基的立体阻碍作用。

  DOI：

  10.1071/ch9792507

文献信息

• TUMOR TARGETING AGENTS AND USES THEREOF
  申请人：Karyon OY

  公开号：EP1549667A1

  公开（公告）日：2005-07-06
• Tumor targeting agents and uses thereof
  申请人：Bergman Mathias

  公开号：US20060263294A1

  公开（公告）日：2006-11-23

  This invention relates to novel tumor targeting motifs, units and agents, as well as tumor targeting peptides and ana-logues thereof. The targeting agents typically comprise at least one targeting motif, Aa-Bb-Cc, and at least one ef-fector unic. The invention further relates to specific tumor targeting peptides, pharmaceutical and diagnostic com-posisitons comprising such peptides. Disclosed are also methods for diagnosing or treating cancer.
• [EN] TUMOR TARGETING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE CIBLAGE TUMORAL ET LEURS UTILISATIONS
  申请人：KARYON OY

  公开号：WO2004031219A1

  公开（公告）日：2004-04-15

  This invention relates to novel tumor targeting motifs, units and agents, as well as tumor targeting peptides and ana-logues thereof. The targeting agents typically comprise at least one targeting motif, Aa-Bb-Cc, and at least one ef-fector unic. The invention further relates to specific tumor targeting peptides, pharmaceutical and diagnostic com-posisitons comprising such peptides. Disclosed are also methods for diagnosing or treating cancer.
• [EN] TUMOR TARGETING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE CIBLAGE TUMORAL ET UTILISATIONS DE CEUX-CI
  申请人：KARYON OY

  公开号：WO2004031220A1

  公开（公告）日：2004-04-15

  This invention relates to novel tumor targeting motifs, units and agents, as well as tumor targeting peptides and ana-logues thereof. The targeting agents typically comprise at least one targeting motif, Aa-Bb-Cc, and at least one ef-fector unic. The invention further relates to specific tumor targeting peptides, pharmaceutical and diagnostic com-posisitons comprising such peptides. Disclosed are also methods for diagnosing or treating cancer.
• [EN] TUMOR TARGETING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE CIBLAGE DE TUMEUR ET UTILISATIONS DE CEUX-CI
  申请人：KARYON OY

  公开号：WO2004031221A1

  公开（公告）日：2004-04-15

  This invention relates to novel tumor targeting motifs, units and agents, as well as tumor targeting peptides and analogues thereof. The targeting agents typically comprise at least one targeting motif, Aa-Bb-Cc, and at least one effector unit. The invention further relates to specific tumor targeting peptides, pharmaceutical and diagnostic composisitons comprising such peptides. Disclosed are also methods for diagnosing or treating cancer.