[EN] DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES<br/>[FR] DÉRIVÉS DE DIHYDROPYRIMIDINE ET LEURS UTILISATIONS DANS LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE B OU DE MALADIES INDUITES PAR LE VIRUS DE L'HÉPATITE B
申请人:JANSSEN SCIENCES IRELAND UNLIMITED CO
公开号:WO2019214610A1
公开(公告)日:2019-11-14
Provided herein are dihydropyrimidine derivatives which are useful in the treatment of HBV infection or HBV-induced diseases, as well as pharmaceutical or medical applications thereof.
本文提供了一种二氢嘧啶衍生物,可用于治疗乙型肝炎感染或由乙型肝炎引起的疾病,以及其药用或医学应用。
[EN] BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS<br/>[FR] COMPOSÉS RELIÉS PAR UN PONT EN TANT QU'INHIBITEURS DE L'INTÉGRASE DU VIH
申请人:MERCK SHARP & DOHME
公开号:WO2010088167A1
公开(公告)日:2010-08-05
Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, χ3, Y, Z, R1, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Tandem Hydroformylation/Hydrogenation of Alkenes to Normal Alcohols Using Rh/Ru Dual Catalyst or Ru Single Component Catalyst
作者:Kohei Takahashi、Makoto Yamashita、Kyoko Nozaki
DOI:10.1021/ja307998h
日期:2012.11.14
The catalystsystem for tandemhydroformylation/hydrogenation of terminal alkenes to the corresponding homologated normal alcohol was developed. The reaction mechanism for the Rh/Rudualcatalyst was investigated by real-time IR monitoring experiments and (31)P NMR spectroscopy, which proved the mutual orthogonality of Rh-catalyzed hydroformylation and Ru-catalyzed hydrogenation. Detailed investigation
Asymmetric alkene cycloalumination by AlEt3, catalyzed with neomenthylindenyl zirconium η-complexes
作者:Lyudmila V. Parfenova、Pavel V. Kovyazin、Tatyana V. Tyumkina、Tatyana V. Berestova、Leonard M. Khalilov、Usein M. Dzhemilev
DOI:10.1016/j.jorganchem.2012.10.021
日期:2013.1
structures, as well as solvent, affect the overall yield and enantiomeric excess of the reaction product - 3-alkylsubstituted aluminacyclopentanes. The reaction of terminal alkenes with AlEt3, catalyzed by complex 1, in hydrocarbon solvents gives predominantly S-enantiomers of cyclic organoaluminum compounds with enantiomeric excess up to 37%. Complex 2 shows smaller stereoinduction effect and provides
[EN] BRANCHED ADIPIC ACID BASED ESTERS AS NOVEL BASE STOCKS AND LUBRICANTS<br/>[FR] ESTERS À BASE D'ACIDE ADIPIQUE RAMIFIÉ UTILISÉS EN TANT QUE NOUVELLES HUILES DE BASE ET LUBRIFIANTS
申请人:BASF SE
公开号:WO2019110355A1
公开(公告)日:2019-06-13
The presently claimed invention is directed to the use of branched adipic acid esters as lubricants as well as lubricant compositions containing the branched adipic acid esters.