1-(bromomethyl)-2-(2-(2-methoxyethoxy)ethoxy)benzene | 1342540-00-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(bromomethyl)-2-(2-(2-methoxyethoxy)ethoxy)benzene
• 英文别名: 1-(1,4,7-trioxaoctyl)-2-(bromomethyl)benzene；1-(Bromomethyl)-2-[2-(2-methoxyethoxy)ethoxy]benzene
• CAS: 1342540-00-4
• 化学式: C₁₂H₁₇BrO₃
• 分子量: 289.169
• InChiKey: HCLBHDLVARIJFR-UHFFFAOYSA-N

物化性质

• 沸点：
  346.9±32.0 °C(Predicted)
• 密度：
  1.304±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-bis(acetoxymethyl)-4-ethynyl phenol 、 1-(bromomethyl)-2-(2-(2-methoxyethoxy)ethoxy)benzene 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 40.0h， 以65%的产率得到(5-ethylnyl-2-((2-(2-(2-methoxyethoxy)ethoxy)benzyl)oxy)-1,3-phenylene)dimethanol
  参考文献：
  名称：

  Facile Synthesis of an Amphiphilic 1,3,5-Trisubstituted Benzene as a Novel Surface Modifier by Selective Photocyclic Aromatization and Efficient Improvement of Oxygen Permselectivity by the Addition of the Surface Modifier

  摘要：

  一种具有六个羟基和三个寡聚乙烯基团的新型两亲性1,3,5-三取代苯（T-EO）作为二维表面修饰剂，首次通过选择性光环化芳构化方法成功且简单地合成，具有高转化率和选择性。我们基于PVA或聚（三甲基硅基苯乙炔）（poly(SPA)）制备了四种混合膜，这些膜包含新的两亲性环状聚合物（T-EO）或相应的聚合物（P-EO），即T-EO/PVA、P-EO/PVA，以及通过常规溶剂铸造方法（方法I）制备的T-EO/poly(SPA)膜和通过新型溶剂铸造方法（方法II）制备的T-EO/poly(SPA)膜。方法I制备的T-EO/PVA膜和方法II制备的T-EO/poly(SPA)膜在氧气渗透性能方面表现优于方法I制备的P-EO/PVA膜和T-EO/poly(SPA)膜。含有1.0 wt % T-EO的基于PVA的膜表现出最佳性能，即渗透系数α是原始PVA膜的两倍，而PO2没有降低。理想的改进可能是由于T-EO有效的表面修饰所致。

  DOI：

  10.1246/cl.130372
• 作为产物：
  描述：

  二乙二醇单甲醚 在 18-冠醚-6 、 四溴化碳 、 sodium hydride 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 58.0h， 生成 1-(bromomethyl)-2-(2-(2-methoxyethoxy)ethoxy)benzene
  参考文献：
  名称：

  Facile Synthesis of an Amphiphilic 1,3,5-Trisubstituted Benzene as a Novel Surface Modifier by Selective Photocyclic Aromatization and Efficient Improvement of Oxygen Permselectivity by the Addition of the Surface Modifier

  摘要：

  一种具有六个羟基和三个寡聚乙烯基团的新型两亲性1,3,5-三取代苯（T-EO）作为二维表面修饰剂，首次通过选择性光环化芳构化方法成功且简单地合成，具有高转化率和选择性。我们基于PVA或聚（三甲基硅基苯乙炔）（poly(SPA)）制备了四种混合膜，这些膜包含新的两亲性环状聚合物（T-EO）或相应的聚合物（P-EO），即T-EO/PVA、P-EO/PVA，以及通过常规溶剂铸造方法（方法I）制备的T-EO/poly(SPA)膜和通过新型溶剂铸造方法（方法II）制备的T-EO/poly(SPA)膜。方法I制备的T-EO/PVA膜和方法II制备的T-EO/poly(SPA)膜在氧气渗透性能方面表现优于方法I制备的P-EO/PVA膜和T-EO/poly(SPA)膜。含有1.0 wt % T-EO的基于PVA的膜表现出最佳性能，即渗透系数α是原始PVA膜的两倍，而PO2没有降低。理想的改进可能是由于T-EO有效的表面修饰所致。

  DOI：

  10.1246/cl.130372

文献信息

• Facile Synthesis of an Amphiphilic 1,3,5-Trisubstituted Benzene as a Novel Surface Modifier by Selective Photocyclic Aromatization and Efficient Improvement of Oxygen Permselectivity by the Addition of the Surface Modifier
  作者：Jianjun Wang、Toshiki Aoki、Lijia Liu、Takeshi Namikoshi、Masahiro Teraguchi、Takashi Kaneko

  DOI：10.1246/cl.130372

  日期：2013.9.5

  An amphiphilic 1,3,5-trisubstituted benzene as a new 2D surface modifier (T-EO) which has six hydroxy groups and three oligoethylene groups was successfully and easily synthesized by selective photocyclic aromatization in high conversion and selectivity for the first time. We prepared four kinds of blend membranes based on PVA or poly(trimethylsilylphenylacetylene) (poly(SPA)) containing the new amphiphilic cyclic trimer (T-EO) or the corresponding polymer (P-EO), that is, T-EO/PVA, P-EO/PVA, and T-EO/poly(SPA) membranes prepared by conventional solvent casting method (Method I) and T-EO/poly(SPA) membranes prepared by a new solvent casting method (Method II). T-EO/PVA membranes by Method I and T-EO/poly(SPA) membranes by Method II showed better performance in oxygen permeation than P-EO/PVA membranes by Method I and T-EO/poly(SPA) membranes by Method I, respectively. A PVA-based membrane containing 1.0 wt % T-EO showed the best performance, that is, the α became twice that of the original PVA membrane without any decrease in PO2. The ideal improvement may be caused by effective surface modification by T-EO.

  一种具有六个羟基和三个寡聚乙烯基团的新型两亲性1,3,5-三取代苯（T-EO）作为二维表面修饰剂，首次通过选择性光环化芳构化方法成功且简单地合成，具有高转化率和选择性。我们基于PVA或聚（三甲基硅基苯乙炔）（poly(SPA)）制备了四种混合膜，这些膜包含新的两亲性环状聚合物（T-EO）或相应的聚合物（P-EO），即T-EO/PVA、P-EO/PVA，以及通过常规溶剂铸造方法（方法I）制备的T-EO/poly(SPA)膜和通过新型溶剂铸造方法（方法II）制备的T-EO/poly(SPA)膜。方法I制备的T-EO/PVA膜和方法II制备的T-EO/poly(SPA)膜在氧气渗透性能方面表现优于方法I制备的P-EO/PVA膜和T-EO/poly(SPA)膜。含有1.0 wt % T-EO的基于PVA的膜表现出最佳性能，即渗透系数α是原始PVA膜的两倍，而PO2没有降低。理想的改进可能是由于T-EO有效的表面修饰所致。
• Facile synthesis of five 2D surface modifiers by highly selective photocyclic aromatization and efficient enhancement of oxygen permselectivities of three polymer membranes by surface modification using a small amount of the 2D surface modifiers
  作者：Jianjun Wang、Yu Zang、Guanwu Yin、Toshiki Aoki、Hiroyuki Urita、Ken Taguwa、Lijia Liu、Takeshi Namikoshi、Masahiro Teraguchi、Takashi Kaneko、Liqun Ma、Hongge Jia

  DOI：10.1016/j.polymer.2013.11.046

  日期：2014.3

  A facile synthesis of novel five 2D (planar) surface modifiers having a triphenylbenzene derivatives as a 2D structure has been achieved by the highly selective photocyclic aromatization reaction. Efficient enhancement of oxygen permselectivities through the three polymer membranes has been achieved by adding a small amount (< 5.0 wt%) of the 20 surface modifiers. Among the five 2D surface modifiers, a modifier compound having oligoethylene oxide groups showed the best performance for the enhancement. These improvements were thought to be caused mainly by improvement of the solution selectivity on the membrane surface where the 2D surface modifiers were accumulated. In some of the surface-modified blend membranes, their plots in the P-O2(-alpha) graph were over or close to the upper boundary line by Robeson in 1991. Since all the membranes containing the 2D surface modifiers showed better permselectivities than the corresponding substrate membranes, it is very promising for the future. (C) 2013 Elsevier Ltd. All rights reserved.