3-(2-fluorophenyl)pentane-2,4-dione | 1308677-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-fluorophenyl)pentane-2,4-dione
• CAS: 1308677-47-5
• 化学式: C₁₁H₁₁FO₂
• 分子量: 194.206
• InChiKey: RAHOCDVEAZSYMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-fluorophenyl)pentane-2,4-dione 、 碘甲烷 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以7%的产率得到C₁₂H₁₃FO₂
  参考文献：
  名称：

  无环 1,3-二酮的不对称氰基化

  摘要：

  发现含有氢键供体和路易斯酸性镁中心的新型双功能配合物是结构灵活的无环 1,3-二酮的立体选择性氰基化催化剂。可以获得立体化学定义的连位三级和四级立体中心，并进一步衍生为多官能化分子。

  DOI：

  10.1002/anie.202208443
• 作为产物：
  描述：

  2-氟碘苯 、 乙酰丙酮 在 6,7-dihydro-5H-diimidazo[1,2-a:2',1'-c][1,4]diazepine 、 copper(II) acetate monohydrate 、 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 6.0h， 以65%的产率得到3-(2-fluorophenyl)pentane-2,4-dione
  参考文献：
  名称：

  铜（II）和1,1'-三亚甲基-2,2'-联咪唑促进的乙酰丙酮与芳基碘化物的芳基化

  摘要：

  开发了一种新的高效方法，可在100°C下在Cu（II）和1,1'-三亚甲基-2,2'-联咪唑的辅助下进行乙酰丙酮与芳基碘的反应。以优异的产率获得了3-芳基-2,4-戊二酮。

  DOI：

  10.1002/cjoc.201190083

文献信息

• Copper(II) and 1,1′-Trimethylene-2,2′-biimidazole-promoted Arylation of Acetylacetone with Aryl Iodides
  作者：Jianli Liu、Runsheng Zeng、Chunmei Zhou、Jianping Zou

  DOI：10.1002/cjoc.201190083

  日期：2011.2

  A new and efficient way was developed to carry out the reaction of acetylacetone with aryl iodides under the assistance of Cu(II) and 1,1′‐trimethylene‐2,2′‐biimidazole at 100°C. 3‐Aryl‐2,4‐pentanediones were obtained in excellent yields.

  开发了一种新的高效方法，可在100°C下在Cu（II）和1,1'-三亚甲基-2,2'-联咪唑的辅助下进行乙酰丙酮与芳基碘的反应。以优异的产率获得了3-芳基-2,4-戊二酮。
• 6-(2-Fluorophenyl)-Triazolopyrimidines, Method For The Production Thereof, Use Thereof For Controlling Harmful Fungi, And Agents Containing The Same
  申请人：Blettner Carsten

  公开号：US20080032889A1

  公开（公告）日：2008-02-07

  Substituted triazolopyrimidines of the formula I in which the substituents are as defined below: R 1 is alkyl, halocycloalkyl, alkenyl, cycloalkyl, cycloalkenyl, halocycloalkenyl, alkynyl, haloalkynyl or naphthyl, or a five- or six-membered saturated, partially unsaturated or aromatic heterocycle comprising one to four heteroatoms from the group consisting of O, N and S, R 2 is hydrogen, alkyl or one of the groups mentioned under R 1 ; R 1 and/or R 2 may carry one to four identical or different groups R a : R a is chlorine, bromine, iodine, cyano, nitro, hydroxyl, alkyl, alkylcarbonyl, cycloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, alkylthio, alkylamino, dialkyl-amino, alkenyl, cycloalkenyl, alkenyloxy, haloalkenyloxy, alkynyl, halo-alkynyl, alkynyloxy, haloalkynyloxy, cycloalkoxy, cycloalkenyloxy, oxyalkylenoxy, naphthyl, a five- to ten-membered saturated, partially unsaturated or aromatic heterocycle comprising one to four heteroatoms from the group consisting of O, N and S, where these aliphatic, alicyclic or aromatic groups for their part may be substituted according to the description; and X is halogen; processes for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic harmful fungi.
• Desymmetric Cyanosilylation of Acyclic 1,3‐Diketones
  作者：Pan Xu、Chang Shen、Aiqing Xu、Kam‐Hung Low、Zhongxing Huang

  DOI：10.1002/anie.202208443

  日期：2022.9.12

  bifunctional complex containing both a hydrogen bond donor and a Lewis acidic magnesium center was discovered to be a stereoselective cyanosilylation catalyst for structurally flexible acyclic 1,3-diketones. Stereochemically defined vicinal tertiary and quaternary stereocenters can be obtained and further derived to polyfunctionalized molecules.

  发现含有氢键供体和路易斯酸性镁中心的新型双功能配合物是结构灵活的无环 1,3-二酮的立体选择性氰基化催化剂。可以获得立体化学定义的连位三级和四级立体中心，并进一步衍生为多官能化分子。