2-乙氧基-2-甲基吡嗪 | 20920-83-6

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡嗪类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-乙氧基-2-甲基吡嗪
• 中文别名: 2-(乙氧基甲基)-苯酚
• 英文名称: (ethoxymethyl)2-phenol
• 英文别名: 2-(ethoxymethyl)phenol；o-(ethoxymethyl)phenol；2-ethoxymethylphenol；2-ethoxymethyl-phenol；2-Aethoxymethyl-phenol；2-Oxy-1¹-aethoxy-1-methyl-benzol
• CAS: 20920-83-6
• 化学式: C₉H₁₂O₂
• 分子量: 152.193
• InChiKey: GNNUWFUVNWRCEO-UHFFFAOYSA-N

物化性质

• 沸点：
  79-82 °C(Press: 2 Torr)
• 密度：
  1.038 g/mL at 25 °C(lit.)
• 闪点：
  150 °F
• LogP：
  1.75
• 物理描述：
  Colourless to yellowish oily liquid, sweet smokey, vanillic odour
• 溶解度：
  slightly soluble in water; soluble in oils
• 折光率：
  1.517-1.523

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2909500000

制备方法与用途

使用限量：

• 肉制品：FEMA(mg/kg) 为 4.0
• 汤品：FEMA(mg/kg) 为 4.0
• 调味品：FEMA(mg/kg) 为 4.0
• 谷类制品：FEMA(mg/kg) 为 4.0
• 泡菜：FEMA(mg/kg) 为 4.0

反应信息

• 作为反应物：
  描述：

  2-乙氧基-2-甲基吡嗪 在 三乙胺 、 三氯化磷 作用下， 以 甲苯 为溶剂， 生成 phosphorochloridite
  参考文献：
  名称：

  HYDROFORMYLATION PROCESS UTILIZING MULTIDENTATE PHOSPHITE LIGANDS

  摘要：

  公开号：

  EP1214282B1
• 作为产物：
  描述：

  1-金刚烷基溴甲酮 在 三甲基镓 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 4.0h， 生成 2-乙氧基-2-甲基吡嗪
  参考文献：
  名称：

  Reactions of o-Quinone Methides with Pyridinium Methylides: A Diastereoselective Synthesis of 1,2-Dihydronaphtho[2,1-b]furans and 2,3-Dihydrobenzofurans

  摘要：

  A simple, general route to the 1,2-dihydronaphtho[2,1-b]furans and 2,3-dihydrobenzofurans substituted at C-2 by an acyl or aryl group, starting from phenolic Mannich bases and pyridinium ylides, has been developed. The mechanism of the reaction is believed to involve the formation of the o-quinone methide intermediate, Michael-type addition of the ylide to the o-quinone methide, followed by intramolecular nucleophilic substitution.

  DOI：

  10.1021/jo400621r

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Hydroxy-1-aminoindans and Derivatives:  Preparation, Stability, and Reactivity
  作者：Yaacov Herzig、Lena Lerman、Willy Goldenberg、David Lerner、Hugo E. Gottlieb、Abraham Nudelman

  DOI：10.1021/jo052621m

  日期：2006.5.1

  The chemical stability and reactivity of hydroxy-1-aminoindans and their N-propargyl derivatives are strongly affected by the position of the OH group and its orientation relative to that of the amino moiety. Thus, the 4- and 6-OH regioisomers were found to be stable, while the 5-OH analogues were found to be inherently unstable as the free bases. The latter, having a para orientation between the OH

  羟基-1-氨基茚满及其氮的化学稳定性和反应活性-炔丙基衍生物受到OH基团的位置及其相对于氨基部分的取向的强烈影响。因此，发现4-和6-OH区域异构体是稳定的，而发现5-OH类似物作为游离碱固有地不稳定。在OH和氨基部分之间具有对位取向的后者只能作为它们的盐酸盐被分离出来。7-羟基-1-氨基茚满和7-羟基-1-炔丙基氨基茚满是中间情况。尽管即使作为游离碱也足够稳定，但它们在某些实验条件下仍表现出出乎意料的反应性。5-羟基和7-羟基氨基茚满的不稳定性归因于它们向相应的反应性醌甲基化物（QM）中间体的容易转化。该Ø经由狄尔斯-阿尔德反应（Diels-Alder reaction）成功地从乙基-乙烯基醚中捕获了从7-羟基-氨基茚满获得的-QM，得到三环缩醛32a，b。
• Copper(I)-Catalyzed Hydroalkoxylation/Hydrogen-Bonding-Induced Asymmetric Hetero-Diels-Alder Cycloaddition Cascade: An Approach to Aromatic Spiroketals
  作者：Xin Li、Jijun Xue、Chusheng Huang、Ying Li

  DOI：10.1002/asia.201101056

  日期：2012.5

  One thing leads to another: Bis(benzannelated) 5,6‐spiroketal skeletons can be constructed by an efficient cascade process involving an unprecedented CuI‐catalyzed intramolecular alkyne hydroalkoxylation and an asymmetric hetero‐Diels–Alder cycloaddition. The method yields a series of diversely functionalized spiroketals from two readily available open‐chained starting materials in good yields and

  一件事导致另一件事：可以通过有效的级联过程，包括前所未有的Cu I催化的分子内炔烃加氢烷氧基化和不对称杂Diels-Alder环加成反应，构建双（苯甲酰化）5,6-螺酮骨架。该方法可从两种容易获得的开链起始原料中以高收率和出色的非对映选择性产生一系列功能多样的螺缩酮。
• Zinc-mediated reactions on salicylaldehyde for Botrytis cinerea control
  作者：Antoine Franche、Claire Imbs、Antoine Fayeulle、Franck Merlier、Muriel Billamboz、Estelle Léonard

  DOI：10.1016/j.cclet.2019.08.053

  日期：2020.3

  Chemical control is a necessity and as much as possible, eco-friendly conditions and bioresources to obtain these chemicals should be used. In this context, a series of products was obtained from salicylaldehyde using zinc as a powerful reagent and tested for antifungal activity against Botrytis cinerea

  摘要灰葡萄孢是一种坏死性真菌，会影响各种植物。必须进行化学控制，并应尽可能使用生态友好的条件和生物资源来获得这些化学物质。在这种情况下，使用锌作为强力试剂从水杨醛中获得了一系列产品，并测试了其对灰葡萄孢的抗真菌活性。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。